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  1. 12561
    “…METHODS: Quantitative real-time PCR (qRT-PCR) was conducted to detect the expression level of messenger RNA of ACTA2-AS1, miR-143-3p and SMAD3 in tumor tissues and cells. …”
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    A novel mechanism by which ACTA2-AS1 promotes cervical cancer progression: acting as a ceRNA of miR-143-3p to regulate SMAD3 expression
  2. 12562
    “…The miRNA binding affinity could therefore be changed by SNP(s) located at the 3′ untranslated regions (3′UTR) of the target messenger RNA (mRNA) which miRNA(s) interacts with. …”
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    Pinpointing miRNA and genes enrichment over trait-relevant tissue network in Genome-Wide Association Studies
  3. 12563
    “…A conservatively filtered list of 57 messenger RNA targets was obtained; the top biological processes associated were regulation of cell population proliferation (P < 0.000001), cellular response to chemical stimulus (P < 0.000001) and cell surface receptor signalling pathway (P < 0.000001). …”
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    Equine synovial fluid small non-coding RNA signatures in early osteoarthritis
  4. 12564
    por Wang, Xiaojuan, Bai, Ming
    Publicado 2021
    “…Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression of circTM7SF3, its linear form TM7SF3, microRNA-206 (miR-206) and aspartyl (asparaginyl) β-hydroxylase (ASPH) messenger RNA (mRNA). Cell viability and apoptosis were examined by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and flow cytometry. …”
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    CircTM7SF3 contributes to oxidized low-density lipoprotein-induced apoptosis, inflammation and oxidative stress through targeting miR-206/ASPH axis in atherosclerosis cell model in vitro
  5. 12565
    “…Activated AMPK upregulated the messenger RNA expression and protein levels of atrogin-1, a muscle-specific ubiquitin ligase, in the myocardium. …”
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    Metformin-Enhanced Cardiac AMP-Activated Protein Kinase/Atrogin-1 Pathways Inhibit Charged Multivesicular Body Protein 2B Accumulation in Ischemia–Reperfusion Injury
  6. 12566
    “…METHODS: Differential gene expression analysis were performed on The Cancer Genome Atlas Urothelial Bladder Carcinoma (TCGA-BLCA) datasets to identify differentially expressed messenger RNAs (mRNAs), lncRNAs, and microRNAs (miRNAs). …”
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    Comprehensive analysis of the lncRNA-miRNA-mRNA regulatory network for bladder cancer
  7. 12567
    “…A semi-structured, self-administered questionnaire was prepared in Google form and circulated to the sampled health workers through various social media platforms like face book, messenger, Instagram and g-mails. A total of 650 invitations were send and among them 420 responded and among them only 399 provided complete response. …”
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    Knowledge and attitude on prevention of COVID-19 among community health workers in Nepal-a cross-sectional study
  8. 12568
    “…BACKGROUND: The Pfizer-BioNTech COVID-19 vaccine uses a novel messenger RNA technology to elicit a protective immune response. …”
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    Physiologic Response to the Pfizer-BioNTech COVID-19 Vaccine Measured Using Wearable Devices: Prospective Observational Study
  9. 12569
    por Thompson, Mark G., Stenehjem, Edward, Grannis, Shaun, Ball, Sarah W., Naleway, Allison L., Ong, Toan C., DeSilva, Malini B., Natarajan, Karthik, Bozio, Catherine H., Lewis, Ned, Dascomb, Kristin, Dixon, Brian E., Birch, Rebecca J., Irving, Stephanie A., Rao, Suchitra, Kharbanda, Elyse, Han, Jungmi, Reynolds, Sue, Goddard, Kristin, Grisel, Nancy, Fadel, William F., Levy, Matthew E., Ferdinands, Jill, Fireman, Bruce, Arndorfer, Julie, Valvi, Nimish R., Rowley, Elizabeth A., Patel, Palak, Zerbo, Ousseny, Griggs, Eric P., Porter, Rachael M., Demarco, Maria, Blanton, Lenee, Steffens, Andrea, Zhuang, Yan, Olson, Natalie, Barron, Michelle, Shifflett, Patricia, Schrag, Stephanie J., Verani, Jennifer R., Fry, Alicia, Gaglani, Manjusha, Azziz-Baumgartner, Eduardo, Klein, Nicola P.
    Publicado 2021
    “…RESULTS: The effectiveness of full messenger RNA (mRNA) vaccination (≥14 days after the second dose) was 89% (95% confidence interval [CI], 87 to 91) against laboratory-confirmed SARS-CoV-2 infection leading to hospitalization, 90% (95% CI, 86 to 93) against infection leading to an ICU admission, and 91% (95% CI, 89 to 93) against infection leading to an emergency department or urgent care clinic visit. …”
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    Effectiveness of Covid-19 Vaccines in Ambulatory and Inpatient Care Settings
  10. 12570
    “…METHODS: HUVECs were transfected with a miR-146a-5p mimic, small-interfering RNA (siRNA) (si-TRAF6, and si-IRAK1), and were then stimulated with LPS for 24 h. The messenger (mRNA) and the protein levels of p-NF-κB/NF-κB, NLRP3, Caspase-1, pro-inflammatory cytokine [interleukin (IL)-6, IL-1β and tumor necrosis factor alpha (TNF-α)] in the HUVECs were analyzed by quantitative real-time polymerase chain reactions (PCRs) and western blot assays, respectively. …”
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    MicroRNA-146a-5p alleviates lipopolysaccharide-induced NLRP3 inflammasome injury and pro-inflammatory cytokine production via the regulation of TRAF6 and IRAK1 in human umbilical vein endothelial cells (HUVECs)
  11. 12571
    “…Bepirovirsen is an antisense oligonucleotide targeting all HBV messenger RNAs; in cell culture and animal models, bepirovirsen leads to reductions in HBV-derived RNAs, HBV DNA and viral proteins. …”
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    Safety, tolerability and antiviral activity of the antisense oligonucleotide bepirovirsen in patients with chronic hepatitis B: a phase 2 randomized controlled trial
  12. 12572
    “…The purpose of this study was to identify novel abnormally regulated lncRNA–microRNA (miRNA)–messenger RNA (mRNA) competing endogenous RNA (ceRNA) networks that may suggest new therapeutic targets for LUAD or relate to LUAD prognosis. …”
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    Identification of a novel prognosis-associated ceRNA network in lung adenocarcinoma via bioinformatics analysis
  13. 12573
    “…The results also showed that Sputnik V AEs were more similar to other vector vaccines (132 units) than with messenger RNA vaccines (241 units) according to the average Euclidean distance between the vectors of AE frequencies. …”
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    Mild Adverse Events of Sputnik V Vaccine in Russia: Social Media Content Analysis of Telegram via Deep Learning
  14. 12574
    “…SETTING AND PARTICIPANTS: Residents from 5 nursing homes assessed before vaccination, and 5 weeks and 6 months post vaccination, with the BNT162b2 messenger RNA SARS-CoV-2 vaccine. METHODS: Comprehensive clinical assessment was performed, including assessment for comorbidity, frailty, and SARS-CoV-2 infection history. …”
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    Previous SARS-CoV-2 Infection, Age, and Frailty Are Associated With 6-Month Vaccine-Induced Anti-Spike Antibody Titer in Nursing Home Residents
  15. 12575
    “…Dihydroethidium (DHE) staining and glutathione (GSH) and malondialdehyde (MDA) production were determined to assess the extent of oxidative stress. The messenger RNA (mRNA) levels of proinflammatory cytokines were detected using real-time quantitative polymerase chain reaction (RT-qPCR) to evaluate the extent of neuroinflammation. …”
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    Genistein mitigates oxidative stress and inflammation by regulating Nrf2/HO-1 and NF-κB signaling pathways in hypoxic-ischemic brain damage in neonatal mice
  16. 12576
    “…We further demonstrated that miR-320a-3p could regulate fibrosis by targeting FOXM1 messenger RNA (mRNA) 3′-untranslated region (UTR). …”
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    ALKBH5 promotes lung fibroblast activation and silica-induced pulmonary fibrosis through miR-320a-3p and FOXM1
  17. 12577
    “…The in vitro study of microsome and cytosol extract against apoptosis induced by AFB1 revealed that the level of messenger RNA expression of the Bax and Bad genes of HepG2 cells decreased in the treatment group in a combination of cytosolic and microsomal fractions of the crocodile liver but not for Bcl-2. …”
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    Glutathione-S-transferase activity in various organs of Crocodylus siamensis and its attenuation role in aflatoxin B1-induced cell apoptosis in human hepatocarcinoma cells
  18. 12578
    “…After niclosamide treatment, the levels of OhAOX messenger RNA (mRNA) and OhAOX protein in the whole snail were 14.8 and 2.6 times those in untreated snails, respectively, but varied widely among tissues. …”
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    The identification of alternative oxidase in intermediate host snails of Schistosoma and its potential role in protecting Oncomelania hupensis against niclosamide-induced stress
  19. 12579
    por Price, Ashley M., Olson, Samantha M., Newhams, Margaret M., Halasa, Natasha B., Boom, Julie A., Sahni, Leila C., Pannaraj, Pia S., Irby, Katherine, Bline, Katherine E., Maddux, Aline B., Nofziger, Ryan A., Cameron, Melissa A., Walker, Tracie C., Schwartz, Stephanie P., Mack, Elizabeth H., Smallcomb, Laura, Schuster, Jennifer E., Hobbs, Charlotte V., Kamidani, Satoshi, Tarquinio, Keiko M., Bradford, Tamara T., Levy, Emily R., Chiotos, Kathleen, Bhumbra, Samina S., Cvijanovich, Natalie Z., Heidemann, Sabrina M., Cullimore, Melissa L., Gertz, Shira J., Coates, Bria M., Staat, Mary A., Zinter, Matt S., Kong, Michele, Chatani, Brandon M., Hume, Janet R., Typpo, Katri V., Maamari, Mia, Flori, Heidi R., Tenforde, Mark W., Zambrano, Laura D., Campbell, Angela P., Patel, Manish M., Randolph, Adrienne G.
    Publicado 2022
    “…We estimated vaccine effectiveness by comparing the odds of antecedent full vaccination (two doses of BNT162b2 messenger RNA vaccine) at least 14 days before illness among case patients and controls, according to time since vaccination for patients 12 to 18 years of age and in periods coinciding with circulation of B.1.617.2 (delta) (July 1, 2021, to December 18, 2021) and omicron (December 19, 2021, to February 17, 2022) among patients 5 to 11 and 12 to 18 years of age. …”
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    BNT162b2 Protection against the Omicron Variant in Children and Adolescents
  20. 12580
    por Lv, Jingjing, Wu, Hui, Xu, Junjie, Liu, Jiaye
    Publicado 2022
    “…BACKGROUND: Heterologous prime-boost with ChAdOx1 nCoV-19 vector vaccine (ChAd) and a messenger RNA vaccine (BNT or mRNA-1273) has been widely facilitating mass coronavirus disease 2019 (COVID-19) immunisation. …”
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    Immunogenicity and safety of heterologous versus homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine: a systematic review
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