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  1. 1321
    “…Curcumin molecules have special intrinsic features that can target the intracellular enzymes, genome (DNA) and messengers (RNA). A wide range of studies have been conducted on the physicochemical traits and pharmacological effects of curcumin on different diseases like cardiovascular diseases, diabetes, cancer, rheumatoid arthritis, Alzheimer’s, inflammatory bowel disease (IBD), and even it has wound healing. …”
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    Novel delivery system for natural products: Nano-curcumin formulations
  2. 1322
    “…Reactive oxygen species (ROS) produced by cellular metabolism play an important role as signaling messengers in immune system. ROS elevated in the tumor microenvironment are associated with tumor-induced immunosuppression. …”
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    Reactive Oxygen Species Regulate T Cell Immune Response in the Tumor Microenvironment
  3. 1323
    “…For many years, most studies evaluating the effects of MT2A have focused on reactive oxygen species (ROS), as second messengers that lead to oxidative stress injury of cells and tissues. …”
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    Mammalian Metallothionein-2A and Oxidative Stress
  4. 1324
    “…Among RNA-based regulators, the riboswitches present a large group of specific domains within messenger RNAs able to respond to small metabolites, tRNA, secondary messengers, ions, vitamins or amino acids. …”
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    Emerging applications of riboswitches – from antibacterial targets to molecular tools
  5. 1325
    por Brescia, Marcella, Zaccolo, Manuela
    Publicado 2016
    “…Cyclic nucleotide phosphodiesterases (PDEs) are the only enzymes that degrade the cyclic nucleotides cAMP and cGMP, and play a key role in modulating the amplitude and duration of the signal delivered by these two key intracellular second messengers. Defects in cyclic nucleotide signalling are known to be involved in several pathologies. …”
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    Modulation of Compartmentalised Cyclic Nucleotide Signalling via Local Inhibition of Phosphodiesterase Activity
  6. 1326
    “…The establishment, remodeling and maintenance of tissular architecture during animal development, and even across juvenile to adult life, are deeply regulated by a delicate interplay of extracellular signals, cell membrane receptors and intracellular signal messengers. It is well known that cell adhesion molecules (cell-cell and cell-extracellular matrix) play a critical role in these processes. …”
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    E-cadherin roles in animal biology: A perspective on thyroid hormone-influence
  7. 1327
    “…Both DAG and PA are important second messengers cascading T cell receptor (TCR) signal by recruiting multiple effector molecules, such as RasGRP1, PKCθ, and mTOR. …”
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    Diacylglycerol Kinases in T Cell Tolerance and Effector Function
  8. 1328
    “…Cargo delivery from one nanoparticle is governed by the biunivocal communication with another nanoparticle, which involves two enzymatic processes and the interchange of chemical messengers. The conceptual idea of establishing communication between nanodevices opens the opportunity to develop complex nanoscale systems capable of sharing information and cooperating.…”
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    Interactive models of communication at the nanoscale using nanoparticles that talk to one another
  9. 1329
    “…Circulating miRNAs are highly stable and can act as intercellular messengers to affect many physiological processes. MicroRNAs circulating in body fluids have generated strong interest in their potential use as clinical biomarkers. …”
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    Circulating microRNAs and Bioinformatics Tools to Discover Novel Diagnostic Biomarkers of Pediatric Diseases
  10. 1330
    “…We report here that leukocyte polarity is generated by TIPE2 (TNFAIP8L2), a transfer protein of phosphoinositide second messengers. TIPE2 functioned as a local enhancer of phosphoinositide-dependent signaling and cytoskeleton remodeling, promoting leading edge formation. …”
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    Directing leukocyte polarization and migration by the phosphoinositide transfer protein TIPE2
  11. 1331
    “…Increasing attention has been given to secreted extracellular vesicles (EVs) in the past decades, especially in the portrayal of their molecular cargo and role as messengers in both homeostasis and pathophysiological conditions. …”
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    A Perspective on Extracellular Vesicles Proteomics
  12. 1332
    “…The cyclic nucleotides 3′, 5′-cyclic adenosine monophosphate (cAMP) and 3′, 5′-cyclic guanosine monophosphate (cGMP) are intracellular messengers found in most animal cell types. They usually mediate an extracellular stimulus to drive a change in cell function through activation of their respective cyclic nucleotide-dependent protein kinases, PKA and PKG. …”
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    Cyclic nucleotide signalling in malaria parasites
  13. 1333
    por Cha, Seong-Soo, Seo, Bo-Kyung
    Publicado 2018
    “…The adolescents used mobile messengers for the longest, followed by Internet surfing, gaming, and social networking service use. …”
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    Smartphone use and smartphone addiction in middle school students in Korea: Prevalence, social networking service, and game use
  14. 1334
    por Liu, Dong-wu, Chen, Zhi-wei, Xu, Hong-zhi
    Publicado 2008
    “…Furthermore, some opioid peptides can function as endogenous immune system messengers and participate in the regulation of the immune responses. …”
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    Effects of Leucine-enkephalin on Catalase Activity and Hydrogen Peroxide Levels in the Haemolymph of the Pacific Oyster (Crassostrea gigas)
  15. 1335
    “…These compounds can also act as chemical messengers, physiological regulators or protectants against pathogens in the defense reactions of plants. …”
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    The Use of Mass Spectrometric Techniques to Differentiate Isobaric and Isomeric Flavonoid Conjugates from Axyris amaranthoides
  16. 1336
    por Yu, Kwan Ngok
    Publicado 2019
    “…The two types of RIRE, as well as the associated mechanisms and chemical messengers, have been separately reviewed. The recent report on the potential effects of RIRE on the traditional colony-formation assays has also been reviewed. …”
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    Radiation-induced rescue effect
  17. 1337
    “…Extracellular vesicles (EVs) are considered to be efficient messengers that facilitate the exchange of information within the different tumor cell types. …”
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    Extracellular Vesicles and Carried miRNAs in the Progression of Renal Cell Carcinoma
  18. 1338
    “…Neurotransmitters are endogenous chemical messengers which play an important role in many of the brain functions, abnormal levels being correlated with physical, psychotic and neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s disease. …”
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    Latest Trends in Electrochemical Sensors for Neurotransmitters: A Review
  19. 1339
    “…Then, ROS, as second messengers, regulate a series of physiological and genetic adaptive responses, including remodelling cell wall construction, balancing the uptake of Cd and other ions, refining the antioxidant defence system, and regulating photosynthesis, glutathione synthesis and senescence. …”
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    Salicylic Acid Signals Plant Defence against Cadmium Toxicity
  20. 1340
    “…Several intracellular signaling pathways mediated by chemical messengers (enzymes, protein kinases, transcription factors and others) and cytoplasmic organelles (mitochondria, sarcoplasmic reticulum, nucleus and sarcolemma) are involved in cardioprotective responses. …”
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    Recent Advances in Pharmacological and Non-Pharmacological Strategies of Cardioprotection
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