“…Being a diverse structure itself, PVAT surrounds the human vessels and is characterised by a highly rich secretome, including, amongst others, adipokines, cytokines, gaseous messengers and miRNAs It is implicated in a bidirectional interplay with the adjacent vascular wall, affecting and being affected by aspects of its biology, mainly inflammation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…These enzymes generate lipid second messengers. Among them, phosphatidic acid (PA) is a well-known intracellular messenger that regulates various cellular processes. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Tumor stem cells secrete exosomes that act as important messengers involved in various tumor processes and several studies provide increasing evidence supporting the importance of these exosomes in tumor recurrence and metastasis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…ABSTRACT: Cytokines are small molecular messengers that have profound effects on cancer development. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Mutations in components of the proximal and distal TCR signaling like the TCR-CD3 complex, protein tyrosine kinases and phosphatases, adaptor proteins, second messengers like Ca(2+) mobilization and the MAPK kinase and nuclear factor kappa B (NFκB) pathways impede T cell development and functions, causing immunodeficiency and immune dysregulation manifestations such as autoimmunity and inflammation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Reactive oxygen species (ROS) are important signaling messengers involved in the redox equilibrium and stress response. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In conclusion, BAs passed from their role of simple lipid absorption and metabolism agents to messengers between the gut and liver, modulated by GM.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Intracellular Ca(2+) ions that are thought to be one of the most important second messengers for cellular signaling, have a substantial diversity of roles in regulating a plethora of fundamental cellular physiology such as gene expression, cell division, cell motility and apoptosis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We also discuss the effects of Chinese herbal medicine on asthma from the perspective of cellular endocrinology in the past decade, emphasizing on the roles as intracellular and extracellular messengers of three substances—hormones, substances secreted by pulmonary neuroendocrine cells, and neuroendocrine-related signaling protein—which provide the theoretical basis for clinical application and new drug development.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Extracellular vesicles (EVs) are prominent messengers of this paracrine activity, transporting bioactive molecules that may guide cellular response under different conditions. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Redox adaptation is essential for human health, as the physiological quantities of non-radical reactive oxygen species operate as the main second messengers to regulate normal redox reactions by controlling several sensors. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…[Image: see text] Cyclic dinucleotides (CDNs) are second messengers that activate stimulator of interferon genes (STING). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Connexins are membrane expressed proteins, which could assemble into hexamers to transfer metabolites and secondary messengers. However, its roles in pancreatic cancer metastasis remains unknown. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In addition to the well documented cytokine and chemokine messengers, extracellular vesicles (EVs) have emerged as key regulators of the inflammatory response. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Recommendations for increasing uptake include utilizing Veteran peers, homeless service providers, and healthcare providers as trusted messengers to improve confidence in the vaccine.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The most relevant subthemes were that social isolation led to anxiety, stress, and fear in the SGM community during COVID-19; resilience and adaptation were positive outcomes of the pandemic; histories of medical racism contributed to hesitancy to get tested; and specific messaging from trusted messengers may be needed to encourage SGM communities to get vaccinated. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Free radicals, such as the superoxide anion (O(2)(•−)), act as secondary messengers in many physiological pathways, such as cell survival. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…However, at lower concentrations, ROS function as secondary messengers, playing a critical role as signaling molecules, ensuring regulation of growth and adjustment to multifactorial stresses. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Much of our insight into this phenomenon derives from the role of hyperphosphorylated guanosine derivatives (pppGpp, ppGpp, pGpp; guanosine penta-, tetra- and tri-phosphate, respectively) that are synthesized on starvation cues and act as messengers or alarmones. These molecules, collectively referred to here as (p)ppGpp, orchestrate a complex network of biochemical steps that eventually lead to the repression of stable RNA synthesis, growth, and cell division, while promoting amino acid biosynthesis, survival, persistence, and virulence. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In addition to being a component of DNA and RNA, purine metabolites can be involved in purine signalling in the body as chemical messengers. Abnormalities in purinergic signalling may lead to neuropathy, rheumatic immune diseases, inflammation, tumors, and a wide range of other diseases. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso