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  1. 1841
    “…Identification of the cellular players and molecular messengers that communicate neuronal activity to the vasculature driving cerebral hemodynamics is important for (1) the basic understanding of cerebrovascular regulation and (2) interpretation of functional Magnetic Resonance Imaging (fMRI) signals. …”
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    Cell type specificity of neurovascular coupling in cerebral cortex
  2. 1842
    “…Olfactory cyclic nucleotide-gated (CNG) ion channels are key players in the signal transduction cascade of olfactory sensory neurons. The second messengers cAMP and cGMP directly activate these channels, generating a depolarizing receptor potential. …”
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    Deciphering the function of the CNGB1b subunit in olfactory CNG channels
  3. 1843
    “…Operationally, stereo-selective conformational matching between mitochondrial respiratory complexes, cytosolic and nuclear signaling complexes appears to support the conservation of a critically important set of chemical messengers required for existential regulation of homeostatic cellular processes. …”
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    Antibiotics May Trigger Mitochondrial Dysfunction Inducing Psychiatric Disorders
  4. 1844
    “…Endocannabinoids are amphiphilic molecules that play crucial neurophysiological functions acting as lipid messengers. Antagonists and knockdown of the classical CB1 and CB2 cannabinoid receptors do not completely abolish many endocannabinoid activities, supporting the idea of a mechanism independent of receptors whose mode of action remains unclear. …”
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    Membrane-mediated action of the endocannabinoid anandamide on membrane proteins: implications for understanding the receptor-independent mechanism
  5. 1845
    “…RESULTS: The unconscious users underestimate their usage time by 40%, in spite of 15% more use in the actual usage. Messengers are most-used application regardless of their self-report, and significant preference to SNS applications was observed in addict group. …”
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    Comparing the Self-Report and Measured Smartphone Usage of College Students: A Pilot Study
  6. 1846
    “…Coinhibitory receptors target TCR-proximal signaling and generation of second messengers. Imbalanced activation of such signaling pathways leads to diminished rates of aerobic glycolysis and impaired mitochondrial function resulting in defective anabolic metabolism and altered T cell differentiation. …”
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    Immunometabolic Regulations Mediated by Coinhibitory Receptors and Their Impact on T Cell Immune Responses
  7. 1847
    “…While these oleaginous microorganisms generally produce only small amounts of lipids under optimal growth conditions, their lipid accumulation machinery can be induced by environmental stresses, such as nutrient limitation and an inhospitable physical environmental. As common second messengers of many stress factors, reactive oxygen species (ROS) may act as a regulator of cellular responses to extracellular environmental signaling. …”
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    Reactive Oxygen Species-Mediated Cellular Stress Response and Lipid Accumulation in Oleaginous Microorganisms: The State of the Art and Future Perspectives
  8. 1848
    “…This transition is controlled by binding of a novel tetrameric form of the second messenger, 3΄-5΄ cyclic diguanylic acid (c-di-GMP) to the master repressor, BldD. …”
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    The Streptomyces master regulator BldD binds c-di-GMP sequentially to create a functional BldD(2)-(c-di-GMP)(4) complex
  9. 1849
    “…Recently, emerging evidence has suggested that reactive oxygen species (ROS), important cellular secondary messengers involved in diverse biological events in cancer cells, play essential roles in the EMT process in cancer cells by regulating extracellular matrix (ECM) remodeling, cytoskeleton remodeling, cell–cell junctions, and cell mobility. …”
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    Redox regulation in tumor cell epithelial–mesenchymal transition: molecular basis and therapeutic strategy
  10. 1850
    “…Cyclic di-nucleotides (CDNs) are second messengers in bacteria and metazoan that are as such controlling important biological processes. …”
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    Computational and NMR spectroscopy insights into the conformation of cyclic di-nucleotides
  11. 1851
    “…Signal sensing and transduction by messengers to specific effectors operate by post-translational modification of proteins, among which thiol redox switches play a fundamental role that is just beginning to be understood. …”
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    Thiol Redox Transitions in Cell Signaling: a Lesson from N-Acetylcysteine
  12. 1852
    “…These include elevated concentrations of homocysteine, unbalanced activity of reactive oxygen species both increasing the risk of oxidative stress, increased concentrations of pro-inflammatory messengers, as well as poorer cardio- and cerebrovascular function. …”
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    Glycerophospholipid Supplementation as a Potential Intervention for Supporting Cerebral Structure in Older Adults
  13. 1853
    “…The use of online-communication applications including messengers (e.g. WhatsApp) or social networking services (e.g. …”
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    Is it beneficial to use Internet-communication for escaping from boredom? Boredom proneness interacts with cue-induced craving and avoidance expectancies in explaining symptoms of Internet-communication disorder
  14. 1854
    “…AIM: Reactive oxygen species (ROS) produced by enzymes of the NADPH oxidase family serve as second messengers for cellular signaling. Processes such as differentiation and proliferation are regulated by NADPH oxidases. …”
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    NoxO1 Controls Proliferation of Colon Epithelial Cells
  15. 1855
    “…Endocannabinoids (eCBs) are lipid messengers that are involved in overall body weight control by interfering with manifold central and peripheral regulatory circuits that orchestrate energy homeostasis. …”
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    Endocannabinoids in Body Weight Control
  16. 1856
    “…Cleavage at the internal phosphate ester generates two second messengers, inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG), both of which mediate in diverse cellular functions including the inflammatory response. …”
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    The Role of Phospholipase C Signaling in Macrophage-Mediated Inflammatory Response
  17. 1857
    “…ROS are a double-edged sword; they not only play an important role as secondary messengers in many intracellular signaling cascades, but they also exert indispensable effects on pathological processes involving the female genital tract. …”
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    A novel and compact review on the role of oxidative stress in female reproduction
  18. 1858
    “…Although the proteins of this family were initially described as regulators of tumorigenesis, inflammation, and cell death, they are also found to be involved in the regulation of autophagy and the transfer of lipid secondary messengers, besides contributing to immune function and homeostasis. …”
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    TIPE Family of Proteins and Its Implications in Different Chronic Diseases
  19. 1859
    por Wang, Wenjun, Street, W. Nick
    Publicado 2018
    “…Our MAT model captures not only direct influence from neighboring influencers but also indirect influence passed along by messengers. Moreover, our MAT framework models influence attenuation along diffusion paths, temporal influence decay, and individual diffusion dynamics. …”
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    Modeling and maximizing influence diffusion in social networks for viral marketing
  20. 1860
    “…Oxidative stress activate transcriptional messengers, such as nuclear factor—κB, tangibly contributing to endothelial dysfunction, the initiation and progression of atherosclerosis, irreversible damage after ischemic reperfusion, and even arrhythmia, such as atrial fibrillation. …”
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    Dynamic Action of Carotenoids in Cardioprotection and Maintenance of Cardiac Health
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