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481“…Participants with chronotropic incompetence (hazard ratio, 1.38 [95% CI, 1.06 to 1.79]), higher exercise systolic blood pressure (hazard ratio per SD, 1.20 [95% CI, 1.07 to 1.34]), and impaired heart rate recovery (hazard ratio, 1.51 [95% CI, 1.08 to 2.10]) had a higher risk of CKD compared with those with chronotropic competence, lower exercise systolic blood pressure, and normal heart rate recovery, respectively. These associations remained robust when the exercise variables were mutually adjusted for. …”
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482por Andersson, Linda, Cinato, Mathieu, Mardani, Ismena, Miljanovic, Azra, Arif, Muhammad, Koh, Ara, Lindbom, Malin, Laudette, Marion, Bollano, Entela, Omerovic, Elmir, Klevstig, Martina, Henricsson, Marcus, Fogelstrand, Per, Swärd, Karl, Ekstrand, Matias, Levin, Max, Wikström, Johannes, Doran, Stephen, Hyötyläinen, Tuulia, Sinisalu, Lisanna, Orešič, Matej, Tivesten, Åsa, Adiels, Martin, Bergo, Martin O, Proia, Richard, Mardinoglu, Adil, Jeppsson, Anders, Borén, Jan, Levin, Malin C“…CONCLUSIONS : Our findings suggest that cardiac glycosphingolipids are required to maintain β-adrenergic signalling and contractile capacity in cardiomyocytes and to preserve normal heart function.…”
Publicado 2021
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483por Zhang, Bangying, Chen, Xinpei, Mu, Xiaofeng, Liu, Enzhao, Liu, Tong, Xu, Gang, Bao, Qiankun, Li, Guangping“…MATERIAL/METHODS: We conducted a case-control study with 61 patients who had normal heart rhythm (control group) and 60 patients with AF (research group). …”
Publicado 2021
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484por Kordjalik, Paulina, Szmyd, Bartosz, Karuga, Filip Franciszek, Daszkiewicz, Gabriela, Strzelecka, Iwona, Respondek-Liberska, Maria“…Lymphangioma in the analyzed material coexisted with abnormalities in fetal echo in 78% (n = 25) of cases, especially: heart defect in 50% (n = 16) and with normal heart structure with functional changes in 28% (n = 9). …”
Publicado 2022
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485por BEZNĂ, MARIA CRISTINA, PISOSCHI, CĂTĂLINA, BEZNĂ, MARINELA, DĂNOIU, SUZANA, NEGROIU, CRISTINA-ELENA, MELINTE, PETRU RĂZVAN“…Patients and methods: The research was performed on 120 young subjects (mean age 33 years), with various types of cardiac arrhythmias, on normal heart, without co-existing lesions. Subjects were divided into 3 groups (40 persons). …”
Publicado 2021
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486por Beaudry, Rhys I., Haykowsky, Mark J., MacNamara, James P., Tucker, Wesley J., Rao, Roshni, Haley, Barbara, Sarma, Satyam“…VO(2peak) was significantly reduced in breast cancer survivors relative to healthy controls (15.9 ± 2.0 vs 19.9 ± 3.1 ml/kg/min, p = 0.006), however the heart rate and stroke volume responses to exercise were normal (heart rate reserve; 88 ± 9 vs 85 ± 10 bpm, p = 0.62: stroke volume reserve; 13 ± 6 vs 13 ± 9 ml,p = 0.94). …”
Publicado 2022
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487“…We screened 333 genes differentially expressed between DCM and normal heart samples from GSE141910, and further used Weighted correlation network analysis to identify 197 DCM-related genes. …”
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488por Win, Sithu, Miranda-Schaeubinger, Monica, Gustavo Durán Saucedo, Ronald, Carballo Jimenez, Paula, Flores, Jorge, Mercado-Saavedra, Brandon, Camila Telleria, Lola, Raafs, Anne, Verastegui, Manuela, Bern, Caryn, Tinajeros, Freddy, Heymans, Stephane, Marcus, Rachel, Gilman, Robert H., Mukherjee, Monica“…METHODS AND RESULTS: 139 asymptomatic T. cruzi seropositive subjects with normal heart size and normal LV ejection fraction (EF) (stage A or B) were enrolled in this prospective observational study and underwent paired echocardiograms at baseline and 1-year follow-up. …”
Publicado 2022
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489por Mapelli, Massimo, Zagni, Paola, Ferrara, Roberto, Calbi, Valeria, Mattavelli, Irene, Muratori, Manuela, Kansiime, Jackson, Opira, Cyprian, Agostoni, Piergiuseppe“…Thirteen more patients were screened with cardiac echo, showing a normal heart picture. In our limited series, we found WT cardiac extension in three patients over 16 (19%). …”
Publicado 2022
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490“…RESULTS: Physical examination differentiated normal hearts from abnormal with an accuracy of 95.0% for fellows and 96.3% for consultants. …”
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491por Frustaci, Andrea, Verardo, Romina, Scialla, Rossella, Bagnato, Giulia, Verardo, Margherita, Alfarano, Maria, Russo, Matteo A.“…Results: Protein analysis showed mean M6Pr in FDCM to be 5.4-fold lower than in a normal heart (4289 ± 6595 vs. 23,581 ± 4074, p = 0.0996) (p < 0.001): specifically, 9-fold lower in males, p = 0.009, (p < 0.001) and 3-fold lower in females, p = 0.5799, (p < 0.001) showing, at histology, a mosaic of normal and diseased cells. …”
Publicado 2022
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492por Tang, Yawen, Aryal, Sajesan, Geng, Xiaoxiao, Zhou, Xinyue, Fast, Vladimir G., Zhang, Jianyi, Lu, Rui, Zhou, Yang“…TBX20 is required for normal heart development and cardiac function in adult cardiomyocytes, yet its role in cardiac reprogramming remains undefined. …”
Publicado 2022
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493por de Boer, Martine, te Lintel Hekkert, Maaike, Chang, Jiang, van Thiel, Bibi S., Martens, Leonie, Bos, Maxime M., de Kleijnen, Marion G. J., Ridwan, Yanto, Octavia, Yanti, van Deel, Elza D., Blonden, Lau A., Brandt, Renata M. C., Barnhoorn, Sander, Bautista‐Niño, Paula K., Krabbendam‐Peters, Ilona, Wolswinkel, Rianne, Arshi, Banafsheh, Ghanbari, Mohsen, Kupatt, Christian, de Windt, Leon J., Danser, A. H. Jan, van der Pluijm, Ingrid, Remme, Carol Ann, Stoll, Monika, Pothof, Joris, Roks, Anton J. M., Kavousi, Maryam, Essers, Jeroen, van der Velden, Jolanda, Hoeijmakers, Jan H. J., Duncker, Dirk J.“…Loss of DNA repair permitted normal heart development but subsequently caused progressive deterioration of cardiac function, resulting in overt congestive heart failure and premature death within 6 months. …”
Publicado 2023
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494“…RESULTS: Compared with the normal heart tissue (control group) samples, there were 213 DEGs in the heart tissue samples of patients with dilated cardiomyopathy (treat group), including 101 upregulated and 102 downregulated genes. …”
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495por Jang, Jin-Kun, Park, Jae-Seok, Kim, Yong-Hyen, Choi, Jong-Il, Lim, Hong-Euy, Pak, Hui-Nam, Kim, Young-Hoon“…RESULTS: Fifteen patients (3.3% of total) were diagnosed to have other sustained arrhythmias that included slow-fast type atrioventricular nodal reentrant tachycardia (AVNRT, n=6), atrioventricular reentrant tachycardia (AVRT, n=5) that utilized left posteroseptal (n=4) and parahisian bypass tract (n=1), atrial tachycardia (AT, n=2) originating from the foramen ovale (n=1) and the ostium of coronary sinus (n=1), sustained ventricular tachycardia (VT, n=2) involving one from the apical posterolateral wall of left ventricule in a normal heart and one from an anterolateral wall in an underlying myocardial infarction (MI). …”
Publicado 2010
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496por Misra, Chaitali, Sachan, Nita, McNally, Caryn Rothrock, Koenig, Sara N., Nichols, Haley A., Guggilam, Anuradha, Lucchesi, Pamela A., Pu, William T., Srivastava, Deepak, Garg, Vidu“…In vitro, the mutant GATA4 protein has a reduced DNA binding affinity and transcriptional activity and abolishes a physical interaction with TBX5, a transcription factor critical for normal heart formation. To characterize the mutation in vivo, we generated mice harboring the same mutation, Gata4 G295S. …”
Publicado 2012
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497por Rémond, Marc Gerard Wootton, Atkinson, David, White, Andrew, Hodder, Yvonne, Brown, Alex DH, Carapetis, Jonathan R, Maguire, Graeme Paul“…DISCUSSION: RhFFUS will determine if subtle changes on echocardiography represent the earliest changes of RHD or mere variations of normal heart anatomy. In turn it will inform criteria to be used in determining whether secondary antibiotic prophylaxis should be utilized in individuals with no clear history of ARF and minor abnormalities on echocardiography. …”
Publicado 2012
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498por Santoro, Amato, Alvino, Federico, Antonelli, Giovanni, Caputo, Maria, Padeletti, Margherita, Lisi, Matteo, Mondillo, Sergio“…Strength training (ST) determines concentric chamber remodelling maintaining a normal heart rate (HR). Aim of the study was to compare ET and ST athletes' heart using speckle tracking echocardiography (STE). …”
Publicado 2014
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499por Meshaal, Marwa Sayed, Kassem, Hussein Heshmat, Samir, Ahmad, Zakaria, Ayman, Baghdady, Yasser, Rizk, Hussein Hassan“…Among the patients, 37% had underlying rheumatic heart disease, 26% had prosthetic valves, 23.5% developed IE on top of a structurally normal heart and 8.6% had underlying congenital heart disease. …”
Publicado 2015
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500por Selga, Elisabet, Campuzano, Oscar, Pinsach-Abuin, Mel·lina, Pérez-Serra, Alexandra, Mademont-Soler, Irene, Riuró, Helena, Picó, Ferran, Coll, Mònica, Iglesias, Anna, Pagans, Sara, Sarquella-Brugada, Georgia, Berne, Paola, Benito, Begoña, Brugada, Josep, Porres, José M., López Zea, Matilde, Castro-Urda, Víctor, Fernández-Lozano, Ignacio, Brugada, Ramon“…BACKGROUND: Brugada syndrome (BrS) is a rare genetic cardiac arrhythmia that can lead to sudden cardiac death in patients with a structurally normal heart. Genetic variations in SCN5A can be identified in approximately 20-25% of BrS cases. …”
Publicado 2015
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