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20121por Röttgen, Volker, Tümmler, Lisa-Maria, Koczan, Dirk, Rebl, Alexander, Kuhla, Björn, Vanselow, Jens, Baufeld, Anja“…The mRNA microarray analysis revealed a total of 557 differentially expressed genes comparing both groups (fold change > |1.5| and p < 0.05). OAS1X, MX2 and OAS1Z were among the top downregulated genes in the 20% vs. the 10% group, whereas top upregulated genes comprised BOLA and XCL1. …”
Publicado 2023
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20122por Roy-Vallejo, Emilia, Fernández De Córdoba-Oñate, Sara, Delgado-Wicke, Pablo, Triguero-Martínez, Ana, Montes, Nuria, Carracedo-Rodríguez, Rosa, Zurita-Cruz, Nelly, Marcos-Jiménez, Ana, Lamana, Amalia, Galván-Román, José María, Villapalos García, Gonzalo, Zubiaur, Pablo, Ciudad, Marianela, Rabes, Laura, Sanz, Marta, Rodríguez, Carlos, Villa, Almudena, Rodríguez, Jesús Álvarez, Marcos, Celeste, Hernando, Julia, Díaz-Fernández, Paula, Abad, Francisco, de los Santos, Ignacio, Rodríguez Serrano, Diego A., García-Vicuña, Rosario, Suárez Fernández, Carmen, P. Gomariz, Rosa, Muñoz-Calleja, Cecilia, Fernández-Ruiz, Elena, González-Álvaro, Isidoro, Cardeñoso, Laura, Barrios, Ana, Sanz, Jesús, Casado, Pedro, Gutiérrez, Ángela, Bautista, Azucena, Hernández, Pilar, Ruiz Giménez, Nuria, Moyano, Berta, Gil, Paloma, Jesús Delgado, María, Parra, Pedro, Sánchez, Beatriz, Sáez, Carmen, Fernández Rico, Marta, Arévalo Román, Cristina, Castañeda, Santos, Llorente, Irene, G. Tomero, Eva, García Castañeda, Noelia, Uriarte, Miren, Fontán García-Rodrigo, Leticia, Domingo García, Diego, Alarcón Cavero, Teresa, Auxiliadora Semiglia Chong, María, Gutiérrez Cobos, Ainhoa, Sánchez-Madrid, Francisco, Martín Gayo, Enrique, Sánchez-Cerrillo, Ildefonso, Martínez-Fleta, Pedro, López-Sanz, Celia, Gabrie, Ligia, del Campo Guerola, Luciana, Tejedor, Reyes, Ancochea, Julio, García Castillo, Elena, Ávalos, Elena, Sánchez-Azofra, Ana, Alonso, Tamara, Cisneros, Carolina, Valenzuela, Claudia, Javier García Pérez, Francisco, María Girón, Rosa, Aspa, Javier, Marcos, Celeste, del Perpetuo Socorro Churruca, M., Zamora, Enrique, Martínez, Adrián, Barrio Mayo, Mar, Henares Espi, Rosalina, Méndez, Rosa, Arribas, David, Chicot Llano, Marta, González, Begoña, Quicios, Begoña, Patiño, Pablo, Trigueros, Marina, Dominguez Peña, Cristina, Jiménez Jiménez, David, Villamayor, Pablo, Canabal, Alfonso, de la Cámara, Rafael, Ortiz, Javier, Iturrate, Isabel“…CONCLUSION: Genetic variants in HMOX1 (rs2071746), SERPING1 (rs78958998), TMPRSS2 (rs713400), CD69 (rs11052877), TRAF3IP2 (rs33980500), OAS1 (rs2660) and VIPR1 (rs896) could explain heterogeneity in SARS-CoV-2 viremia in our population.…”
Publicado 2023
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20123por Hoffmann, Franziska S., Hofereiter, Johann, Rübsamen, Heike, Melms, Johannes, Schwarz, Sigrid, Faber, Hans, Weber, Peter, Pütz, Benno, Loleit, Verena, Weber, Frank, Hohlfeld, Reinhard, Meinl, Edgar, Krumbholz, Markus“…CONCLUSIONS: We identified effects of FTY-P on astrocytes, namely induction of neurotrophic mediators (LIF, HBEGF, and IL11) and inhibition of TNF-induced inflammatory genes (CXCL10, BAFF, MX1, and OAS2). This supports the view that a part of the effects of fingolimod may be mediated via astrocytes. …”
Publicado 2015
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20124por Parolin, Micol, Miscioscia, Marina, De Carli, Pietro, Cristofalo, Patrizia, Gatta, Michela, Simonelli, Alessandra“…When the interaction with gender was explored, the global score of alexithymia and the “Distant” OAS subscale predicted the number rate relapses only in males. …”
Publicado 2018
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20125por Silverman, Robert H., Zhang, Rong, Jha, Babal K., Ogden, Kristen M., Dong, Beihua, Elliott, Ruth, Zhao, Ling, Patton, John T., Weiss, Susan R.“…The interferon-inducible 2′,5-oligoadenylate (2-5A) synthetases (OAS) and ribonuclease L (RNase L) are components of a potent host antiviral pathway. …”
Publicado 2013
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20126“…E(2) suppressed the IFNλ1-induced upregulation of the antiviral IFN-stimulated genes (ISGs) MxA, OAS2 and ISG15 in epithelial cells, but not fibroblasts. …”
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20127por Somoza, Maria Luisa, Prieto-Moreno Pfeifer, Ana, Martín-Pedraza, Laura, Victorio Puche, Laura, Esteban Rodríguez, Angel, Blanca-López, Natalia, Eva Fernández González, Abel, Fernández-Caldas, Enrique, Morán Morales, Miriam, Fernández-Sánchez, Francisco Javier, López Sánchez, José Damián, Garrido-Lestache, José Luis Subiza, Canto, Gabriela, Blanca, Miguel“…We aimed to assess their role in subjects with peach fruit-induced allergy (anaphylaxis and OAS) and compare skin prick tests (SPT) vs. specific immunoglobulin E (sIgE) for predicting anaphylaxis. …”
Publicado 2021
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20128por Chen, Yubin, Ouyang, Tianyu, Fang, Cheng, Tang, Can-e, Lei, Kaibo, Jiang, Longtan, Luo, Fanyan“…CD19, SELL, and CCR7 had potential diagnostic value for AAA. OAS3, IFIT1, and IFI44L might be predictive factors for aortic rupture.…”
Publicado 2022
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20129por Nakayama, Yosuke, Moriya, Tomohiro, Sakai, Fumihiko, Ikeda, Noriko, Shiozaki, Takuya, Hosoya, Tomohiro, Nakagawa, Hisako, Miyazaki, Tadaaki“…The expression of the Mx1 and Oas1a genes, critical for the viral clearance in the lung tissues was increased by the pre-treatment with LG2055. …”
Publicado 2014
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20130por Darby, Alistair C., McInnes, Colin J., Kjær, Karina Hansen, Wood, Ann R., Hughes, Margaret, Martensen, Pia Møller, Radford, Alan D., Hall, Neil, Chantrey, Julian“…In addition, a novel potential virulence factor showing homology to mammalian oligoadenylate synthetase (OAS) was identified. This family of proteins normally causes activation of an endoribonuclease (RNaseL) within infected cells. …”
Publicado 2014
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20131“…OASL1 is a member of the 2’-5’-oligoadenylate synthetase (OAS) family and promotes viral clearance by activating RNase L. …”
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20132por Sano, Tatsuhiko, Kobayashi, Zen, Takaoka, Ken, Ota, Kiyobumi, Onishi, Iichiroh, Iizuka, Mihoko, Tomimitsu, Hiroyuki, Shintani, Shuzo“…Because fungi usually spread from the paranasal sinuses to the orbital apex in invasive fungal sinusitis (IFS), IFS often presents as an orbital apex syndrome (OAS) characterized by dysfunction of cranial nerves II, III, IV, V1, and VI. …”
Publicado 2018
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20133por Gray-Miceli, Deanna, Bouchaud, Mary, Mitchell, Anne Bradley, DiDonato, Stephen, Siegal, Jan“…Human beings are social in nature and maintaining social interactions, relationships and intimacy are fundamental needs of older adults (OAs) living in assisted living (AL) communities. …”
Publicado 2020
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20134por Tavasolian, Fataneh, Rashidi, Mohsen, Hatam, Gholam Reza, Jeddi, Marjan, Hosseini, Ahmad Zavaran, Mosawi, Sayed Hussain, Abdollahi, Elham, Inman, Robert D.“…We thus propose a theory incorporating HLA antigens, the “original antigenic sin (OAS)” effect, and presentation of viral peptides which could explain with differential susceptibility or resistance to SARS-CoV-2 infections.…”
Publicado 2021
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20135por Ababaike, Mairihaba, Wang, Shutong, Aierken, Palidan, Omatsu, Takashige, Yusufu, Taximaiti“…We investigated high energy, near and mid-infrared optical vortex lasers formed by a 1 μm optical vortex-pumped KTiOAsO(4) (KTA) optical parametric oscillator. The orbital angular momentum (OAM) of the pump beam can be selectively transferred to the signal or idler output by changing the reflectivity of the output coupler. …”
Publicado 2021
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20136“…The NS1 influenza gene plays a pivotal role in the suppression of host antiviral responses, especially by inhibiting interferon (IFN) production and the activities of antiviral proteins, such as dsRNA-dependent serine/threonine-protein kinase R (PKR) and 2′-5′-oligoadenylate synthetase (OAS)/RNase L. NS1 also modulates important aspects of viral RNA replication, viral protein synthesis, and virus replication cycle. …”
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20137por Tang, Enlin“…Based on the analysis of the option characteristics of prepayable housing mortgage loan, the CIR model with GARCH(1, 1) is selected to describe the interest rate change path, and the computer simulation method is used to calculate OAS and then calculate the effective duration and effective convexity of housing mortgage loan under different prepayment rates, so as to understand the interest rate risk of housing mortgage loan in the presence of embedded option.…”
Publicado 2021
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20138“…FFAS may involve one or more target organs, including the oral mucosa, the skin, the gastrointestinal and respiratory tracts, and the cardiovascular system, with various allergic symptoms ranging from oral allergy syndrome (OAS) to severe anaphylaxis. This article reviews the current knowledge on the field of allergic cross-reactivity between fungal allergens and related foods, as well as the diagnosis and treatment on FFAS.…”
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20139por Sarker, Bandhan, Rahaman, Md. Matiur, Islam, Md. Ariful, Alamin, Muhammad Habibulla, Husain, Md. Maidul, Ferdousi, Farzana, Ahsan, Md. Asif, Mollah, Md. Nurul Haque“…Finally, we investigated the binding stability of the top-ranked three drug molecules Nilotinib, Tegobuvir and Proscillaridin with the three top-ranked proposed receptors (AURKA, AURKB, OAS1) by using 100 ns MD-based MM-PBSA simulations and observed their stable performance. …”
Publicado 2023
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20140por Fu, Cheng, Zhu, Wenhui, Cao, Nan, Liu, Wenjun, Lu, Zhier, Wong, Ziyuan, Guan, Kaiting, Hu, Chunyan, Han, Baoting, Zeng, Sen, Fan, Shuangqi“…Furthermore, when compared to rH3N2, rH3N2ΔNS1 exhibited a more pronounced activation of antiviral proteins such as MX1, OAS, STAT1, and TRIM25, as well as antiviral cytokines such as IL-6, IFN-β, and IL-1β. …”
Publicado 2023
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