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20161“…Likewise, the protein kinase R (PKR), and the 2–5 OAS/RNaseL system represent major antiviral pathways and have been extensively studied. …”
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20162por Añaños Bedriñana, Karen Giovanna, Hernández Umaña, Bernardo Alfredo, Rodríguez Martín, José Antonio“…The article analyzes how approaches to “Living Well” as reflected in the Constitution of the State of Bolivia, the Law of the Rights of Mother Earth, and the American Declaration on the Rights of Indigenous Peoples of the Organization of American States (OAS) contribute to understanding the Andean cosmovision of indigenous peoples of the American continent. …”
Publicado 2020
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20163por Kotsev, Stanislav Vasilev, Miteva, Dimitrina, Krayselska, Stanislava, Shopova, Martina, Pishmisheva-Peleva, Maria, Stanilova, Spaska Angelova, Velikova, Tsvetelina“…We discuss some of the major candidate genes that have been identified as potential genetic factors associated with the COVID-19 severity and infection susceptibility: HLA, ABO, ACE2, TLR7, ApoE, TYK2, OAS, DPP9, IFNAR2, CCR2, etc. Further study of genes and genetic variants will be of great benefit for the prevention and assessment of the individual risk and disease severity in different populations. …”
Publicado 2021
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20164“…Given the totality of his presentation and the contributing variables, his medical team considered this to be a case of the newly characterized opioid-associated amnestic syndrome (OAS). This case is significant because of the relative absence of potentially confounding variables on presentation, including antecedent cardiorespiratory failure. …”
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20165“…Diastereoisomeric sugar alcohols (DSAs) with identical numbers of carbon chiral centers and functional groups but with different R/S configurations and optical activities (OAs) were chosen as symmetry-breaking agents for inducing chiral mesostructured BiOBr films (CMBFs) under hydrothermal conditions. …”
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20166“…Thermal degradation studies showed a decrease in the TAs and OAs content under baking (180 °C for 20 min) that was between 7–65% for atropine, depending on the preparation conditions used, between 35–49% for scopolamine and anisodamine, up to 100% for morphine and codeine and between 14–58% for thebaine, papaverine, and noscapine. …”
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20167por Bhat, Shabir A., Shibata, Tomohiro, Leong, Matthew, Plummer, Jasmine, Vail, Eric, Khan, Zakir“…Moreover, severely symptomatic patients have pronounced induction of interferon stimulated genes (ISGs), particularly the oligoadenylate synthetase (OAS) family of genes. Our results are in concurrence with other studies depicting the early induction of IFN-I response in severe COVID-19 patients, providing novel insights about the ISGs involved.…”
Publicado 2022
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20168por Schlaudecker, Elizabeth P, Goll, Johannes, Jensen, Travis, Petrie, Carey, Gelber, Casey, Dexheimer, Phillip, Steinhoff, Mark, Bernstein, David I“…A group of known interferon-alpha/β-inducible genes (IFIT3, OAS3, IFI44L, MX1, OAS2, IFIT1, IFI6) showed higher responses at day 2 for TIV but stronger peak levels by day 28 for the LAIV group (Fig 1). …”
Publicado 2017
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20169por Kumasaka, Natsuhiko, Rostom, Raghd, Huang, Ni, Polanski, Krzysztof, Meyer, Kerstin B., Patel, Sharad, Boyd, Rachel, Gomez, Celine, Barnett, Sam N., Panousis, Nikolaos I., Schwartzentruber, Jeremy, Ghoussaini, Maya, Lyons, Paul A., Calero-Nieto, Fernando J., Göttgens, Berthold, Barnes, Josephine L., Worlock, Kaylee B., Yoshida, Masahiro, Nikolić, Marko Z., Stephenson, Emily, Reynolds, Gary, Haniffa, Muzlifah, Marioni, John C., Stegle, Oliver, Hagai, Tzachi, Teichmann, Sarah A.“…This approach identified 1,275 expression quantitative trait loci (local false discovery rate 10%) that manifested during the responses, many of which were colocalized with susceptibility loci identified by genome-wide association studies of infectious and autoimmune diseases, including the OAS1 splicing quantitative trait locus in a COVID-19 susceptibility locus. …”
Publicado 2023
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20170por Wu, Yifan, Leyk, Stephanie, Torabi, Hanifeh, Höhn, Katharina, Honecker, Barbara, Tauler, Maria del Pilar Martinez, Cadar, Dániel, Jacobs, Thomas, Bruchhaus, Iris, Metwally, Nahla Galal“…A target prediction analysis of the miRNAs revealed the possible identity of the genes targeted by these miRNAs (CXCL10, OAS1, IL7, and CCL5) involved in immunomodulation.…”
Publicado 2023
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20171“…The main immune molecules related to this arboviral disease elucidated in this review are TLR3/7/8, DC-SIGN, HLA-DRB1/HLA-DQB1, TNF, IL1RN, OAS2/3, and CRP. Advances in knowledge about the genetic basis of the immune response during CHIKV infection are essential for expanding the understanding of disease pathophysiology, providing new genetic markers for prognosis, and identifying molecular targets for the development of new drug treatments.…”
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20172por Nakanishi, Tomoko, Willett, Julian, Farjoun, Yossi, Allen, Richard J., Guillen-Guio, Beatriz, Adra, Darin, Zhou, Sirui, Richards, J. Brent“…We identify that alternative splicing in lung, rather than total expression of OAS1, ATP11A, DPP9 and NPNT, is associated with COVID-19 severity. …”
Publicado 2023
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20173por Basnet, Sarmila, Mohanty, Chitrasen, Bochkov, Yury A., Brockman-Schneider, Rebecca A., Kendziorski, Christina, Gern, James E.“…MX1, IFIT2, IFIH1, and OAS3) with nearly identical kinetics, whereas uninfected non-ciliated cells are the primary source of proinflammatory chemokines. …”
Publicado 2023
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20174por Zöller, Tanja, Attaai, Abdelraheim, Potru, Phani Sankar, Ruß, Tamara, Spittau, Björn“…We provide evidence that aging is associated with decreased numbers of cortical microglia and the establishment of a distinct microglia activation profile including upregulation of Ifi204, Lilrb4, Arhgap, Oas1a, Cd244 and Ildr2. Moreover, flow cytometry revealed that aged cortical microglia express increased levels of Cd206 and Cd36. …”
Publicado 2018
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20175por Klein, Fabian, Mitrovic, Mladen, Roux, Julien, Engdahl, Corinne, von Muenchow, Lilly, Alberti-Servera, Llucia, Fehling, Hans Jörg, Pelczar, Pawel, Rolink, Antonius, Tsapogas, Panagiotis“…Transcriptome analysis linked Duxbl to elevated expression of the apoptosis-inducing Oas/RNaseL pathway. RNaseL deficiency or sustained Bcl2 expression led to a partial rescue of cells in Duxbl transgenic mice. …”
Publicado 2019
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20176“…Nine-core immune-related genes including MMP9, PDGFRA, AHNAK, OLR1, RAC3, IGF1, PGF, OAS1, and SH3BP2 were selected to construct a risk score model by multivariate Cox proportional hazards regression analysis. …”
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20177por Ronen, Joshua A, Malik, Faizan A, Wiechmann, Catherine, Kolli, Swapna, Nwojo, Raphael“…The final diagnosis was chronic aspergillus sinusitis and right-sided orbital apex syndrome (OAS). Antibiotics and antifungals were optimized by the infectious disease team. …”
Publicado 2020
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20178por Li, Tianxu, Hu, Xiaofang, Zhang, Tingting, Song, Xingdong, Zhang, Huihui, Dai, Ning, Sheng, Wei, Hou, Xiaolan, Wei, Liangmeng“…A series of immune-related genes that were induced by viral infection, including interferon alfa, IL-1β, retinoic acid–inducible gene-I, Mx, and OAS, were regulated by duTRIM32 expression. DuTRIM32 overexpression inhibits duck Tembusu virus (DTMUV) replication in the early stages of viral infection. …”
Publicado 2021
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20179por Souza-Moreira, Luciana, Tan, Yuan, Wang, Yan, Wang, Jia-Pey, Salkhordeh, Mahmoud, Virgo, Jennifer, Florian, Maria, Murray, Aidan B.P., Watpool, Irene, McIntyre, Lauralyn, English, Shane, Stewart, Duncan J., Mei, Shirley H.J.“…Together with increased expression of antiviral proteins such as MX1, IFITM3, and OAS1, these changes translated to greater effector functions in regulating monocytes and granulocytes while further enhancing MSCs’ ability to block SARS-CoV-2 pseudovirus entry into epithelial cells. …”
Publicado 2022
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20180