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20241
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20242por Elizalde, Patricia V, Cordo Russo, Rosalia, Madera, Santiago, Merin, Sharon S, Chervo, María F, Ebrahimie, Esmaeil, Selth, Luke, Chiauzzi, Violeta A, Dupont, Agustina, Barchuk, Sabrina, Figurelli, Silvina, Lopez Della Vecchia, Daniel, Guzmán, Pablo, Roa, Juan C, Levit, Claudio, Lebersztein, Gabriel, Anfuso, Fabiana, Proietti, Cecilia J, Schillaci, Roxana, Hickey, Theresa E, Tilley, Wayne D, Elizalde, Patricia V“…IFNB1 and its downstream effectors OAS2 and TRIM22 were among the top up-regulated genes. …”
Publicado 2022
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20243por Yamada, Yoshiji, Kato, Kimihiko, Oguri, Mitsutoshi, Horibe, Hideki, Fujimaki, Tetsuo, Yasukochi, Yoshiki, Takeuchi, Ichiro, Sakuma, Jun“…Therefore, 13 novel loci (MOB3C-TMOD4, COL6A3, ADGRL3-CXCL8-MARCH1, OR52E4, TCHP- GIT2, CCDC63, 12q24.1, OAS3, PLCB2-VPS33B, ZNF77, COL6A5, NFKBIL1-NCR3, MUC17) were identified that confer susceptibility to early-onset MI, hypertension, or CKD. …”
Publicado 2018
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20244por Ahmed, Anthony, Dihmes, Sarah E, Kirstie-Kulsa, Mila, Hefner, Amanda, Ljuri, Isidora, Seddo, Mary, Pistillo, Tiana, Khan, Anzalee, Hoptman, Matthew, Lindenmayer, Jean-Pierre“…Remarkably, increased activation in the regional mask when reappraisal statements were provided with emotionally-evocative pictures was inversely correlated with the life history of aggression LHA (r=-0.32, p=0.28, n=14) and OAS (r=-0.284, p=0.34, n=14) aggression scores. …”
Publicado 2020
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20245“…IFI44, OAS1, IFI44L, ISG15, and HERC5 are the five hub genes shared by RA, COVID-19, and SAB. …”
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20246“…Inhibition of caspases using a pan-caspase inhibitor minimally affected cell killing by P/V virus alone, but by contrast, largely reduced cell death mediated by 5-azacytidine treatment alone or in combination with P/V virus infection. 5-Azacytidine pretreatment dampened P/V virus gene expression and growth within the SK-N-AS cell population, which correlated with enhanced expression of important antiviral genes such as interferon-β and OAS2. Taken together, our data support the role of combination treatment using 5-azacytidine and an oncolytic P/V virus for neuroblastoma therapy.…”
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20247“…Mostly symptoms are limited to the mouth and throat causing oral allergy syndrome (OAS). Systemic reactions are extremely rare. We report an 11-year-old boy who experienced a unique anaphylactic reaction after consuming raw carrot juice. …”
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20248por Petronic, Ivana, Nikolic, Dejan, Cirovic, Dragana, Cvjeticanin, Suzana, Knezevic, Tatjana, Raicevic, Mirjana, Brdar, Radivoj, Dzamic, Dragana, Janic, Nenad, Golubovic, Zoran“…The great majority of patients (45.46%) with affected outer anal sphincter (OAS) in the group of SBO were without affection of other muscles, while for the SBA group it was for every third patient. …”
Publicado 2011
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20249por Liu, Man-Qing, Zhou, Dun-Jin, Wang, Xu, Zhou, Wang, Ye, Li, Li, Jie-Liang, Wang, Yi-Zhong, Ho, Wen-Zhe“…PRINCIPAL FINDINGS: Under different conditions (before, during, and after HIV infection), IFN-λ3 significantly inhibited viral replication in macrophages, which was associated with the induction of multiple antiviral cellular factors (ISG56, MxA, OAS-1, A3G/F and tetherin) and IFN regulatory factors (IRF-1, 3, 5, 7 and 9). …”
Publicado 2012
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20250por Gao, Yulong, Wen, Zhiyuan, Dong, Ke, Zhong, Gongxun, Wang, Xiaomei, Bu, Zhigao, Chen, Hualan, Ye, Ling, Yang, Chinglai“…These results indicate the existence of original antigenic sin (OAS) between concurrently circulating H5N1 HPAIV strains, which may need to be taken into consideration in vaccine development against the potential H5N1 HPAIV pandemic.…”
Publicado 2012
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20251por Roberson, Elisha D.O., Liu, Ying, Ryan, Caitriona, Joyce, Cailin E., Duan, Shengui, Cao, Li, Martin, Ann, Liao, Wilson, Menter, Alan, Bowcock, Anne M.“…Sites with inverse correlations between methylation and nearby gene expression include those of KYNU, OAS2, S100A12, and SERPINB3, whose strong transcriptional up-regulation are important discriminators of psoriasis. …”
Publicado 2011
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20252por Flores-Ocelotl, María del Rosario, Rosas-Murrieta, Nora Hilda, Vallejo-Ruiz, Verónica, Reyes-Leyva, Julio, Herrera-Camacho, Irma, Santos-López, Gerardo“…Ten TCID(50) of PoRV stimulated transcription of IFNα, IFNβ, STAT1, STAT2, p48 and OAS genes in neuroblastoma cells, whereas infection with 100 TCID(50) did not stimulate transcription levels more than non-infected cells. …”
Publicado 2011
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20253“…Eight key enzymes involved in lipid metabolism via different pathways were identified as glyceraldehyde-3-phosphate dehydrogenase (GAPDH), phosphoglycerate kinase (PGK), enolase, aspartate aminotransferase (AST), fumarate hydratase (FH), citrate synthase (CS), O-acetyl-serine lyase (OAS-L) and ATP sulfurylase (ATPS). The results suggested that the glycolytic pathway and citrate transport system might be the main routes for lipid anabolism in N-deprived I. galbana, and that the tricarboxylic acid (TCA) cycle, glyoxylate cycle and sulfur assimilation system might be the major pathways involved in lipid catabolism.…”
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20254An essential role for IFN-β in the induction of IFN-stimulated gene expression by LPS in macrophagespor Sheikh, Faruk, Dickensheets, Harold, Gamero, Ana M., Vogel, Stefanie N., Donnelly, Raymond P.“…We found that LPS treatment activated ISGF3 and induced expression of ISGs such as Oas1, Mx1, Ddx58 (RIG-I), and Ifih1 (MDA5) in WT macrophages, but not in macrophages derived from Ifnb1(−/−) mice or Ifnar1(−/−) mice. …”
Publicado 2014
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20255“…Using three different cell lines, we found that telomere elongation up-regulates TERRA signal and down-regulates innate immune genes such as STAT1, ISG15 and OAS3 in vivo. Ectopic TERRA oligonucleotides repressed these genes even in cells with short telomeres under three-dimensional culture conditions. …”
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20256por Kuchta, Krzysztof, Muszewska, Anna, Knizewski, Lukasz, Steczkiewicz, Kamil, Wyrwicz, Lucjan S., Pawlowski, Krzysztof, Rychlewski, Leszek, Ginalski, Krzysztof“…A detailed analysis of sequence and structure diversity of known NTases possessing PAP/OAS1 SBD domain, combined with state-of-the-art comparative modelling, allowed us to identify potential active site residues responsible for catalysis and substrate binding. …”
Publicado 2016
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20257por Ma, Tong-Cui, Zhou, Run-Hong, Wang, Xu, Li, Jie-Liang, Sang, Ming, Zhou, Li, Zhuang, Ke, Hou, Wei, Guo, De-Yin, Ho, Wen-Zhe“…Investigation of the mechanism(s) of BBI action on HIV showed that BBI induced the expression of IFN-β and multiple IFN stimulated genes (ISGs), including Myxovirus resistance protein 2 (Mx2), 2′,5′-oligoadenylate synthetase (OAS-1), Virus inhibitory protein (viperin), ISG15 and ISG56. …”
Publicado 2016
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20258por Li, Yong, Zhu, Chuanlong, Wang, Faxi, Zhu, Tiantian, Li, Jun, Liu, Shufeng, Xiao, Fei“…Mechanistically, silencing SART1 abrogated the antiviral activity of IFN-α, reduced the expression of IFN-stimulated genes (ISGs) Mx, OAS, and PKR, and attenuated JAK-STAT signaling in HepG2 cells, suggesting that SART1 regulates IFN-mediated antiviral activity through JAK-STAT signaling and ISG expression. …”
Publicado 2016
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20259“…Importantly, in an attempt to correlate expression levels with normal tissue reaction to IR, we also identified three other genes CD40, OAS2, and CXCR1 whose expression level fluctuations during radiotherapy were more pronounced in patients developing late normal tissue responses to curative radiotherapy after the end of the radiotherapy treatment. …”
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20260por Wichit, Sineewanlaya, Hamel, Rodolphe, Zanzoni, Andreas, Diop, Fodé, Cribier, Alexandra, Talignani, Loïc, Diack, Abibatou, Ferraris, Pauline, Liegeois, Florian, Urbach, Serge, Ekchariyawat, Peeraya, Merits, Andres, Yssel, Hans, Benkirane, Monsef, Missé, Dorothée“…We show that the expression of the interferon-stimulated proteins MX1, IFIT1, IFIT3 and ISG15, as well as expression of defense response proteins DDX58, STAT1, OAS3, EIF2AK2 and SAMHD1 was significantly up-regulated in these cells upon infection with either virus. …”
Publicado 2019
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