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20301por Beissert, Tim, Koste, Lars, Perkovic, Mario, Walzer, Kerstin C., Erbar, Stephanie, Selmi, Abderraouf, Diken, Mustafa, Kreiter, Sebastian, Türeci, Özlem, Sahin, Ugur“…B18, in contrast, is superior in controlling OAS1, a key IFN-inducible gene involved in viral RNA degradation. …”
Publicado 2017
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20302por Cai, Binxiang, Bai, Qingling, Chi, Xiaojuan, Goraya, Mohsan U., Wang, Long, Wang, Song, Chen, Biao, Chen, Ji-Long“…In addition, several critical IFN-stimulated genes (ISGs) including IFITM3, OASL, OAS1, and ISG15 were significantly upregulated at both mRNA and protein levels in PK-15 cells and infected pigs. …”
Publicado 2017
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20303“…In the corpus callosum and hippocampus of infected animals, overlapping human-specific transcriptional alterations for interferon type 1 and 2 signaling pathways (STAT1, STAT2, IRF9, ISG15, IFI6) and a range of host antiviral responses (MX1, OAS1, RSAD2, BST2, SAMHD1) were observed. Glial cytoskeleton reorganization, oligodendrocyte differentiation and myelin ensheathment (MBP, MOBP, PLP1, MAG, ZNF488) were downregulated. …”
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20304por Guo, Le, Xu, Xi-Qiu, Zhou, Li, Zhou, Run-Hong, Wang, Xu, Li, Jie-Liang, Liu, Jin-Biao, Liu, Hang, Zhang, Biao, Ho, Wen-Zhe“…In addition, TLR3-activated IECs release exosomes that contained the anti-HIV factors, including IFN-stimulated genes (ISGs: ISG15, ISG56, MxB, OAS-1, GBP5, and Viperin) and HIV restriction miRNAs (miRNA-17, miRNA-20, miRNA-28, miRNA-29 family members, and miRNA-125b). …”
Publicado 2018
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20305por Englert, Joshua A., Cho, Michael H., Lamb, Andrew E., Shumyatcher, Maya, Barragan-Bradford, Diana, Basil, Maria C., Higuera, Angelica, Isabelle, Colleen, Vera, Mayra Pinilla, Dieffenbach, Paul B., Fredenburgh, Laura E., Kang, Joyce B., Bhatt, Ami S., Antin, Joseph H., Ho, Vincent T., Soiffer, Robert J., Howrylak, Judie A., Himes, Blanca E., Baron, Rebecca M.“…RESULTS: We identified 687 differentially expressed genes between ARDS and ARDS-HSCT (adjusted p-value < 0.01), including IFI44L, OAS3, LY6E, and SPATS2L that had increased expression in ARDS vs. …”
Publicado 2019
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20306por Panda, Debasis, Gjinaj, Erisa, Bachu, Mahesh, Squire, Erica, Novatt, Hilary, Ozato, Keiko, Rabin, Ronald L.“…Transcriptome analysis revealed that IRF1 regulates constitutive expression of ~300 genes, including antiviral ISGs: OAS2, BST2, and RNASEL and knockdown of any of these IRF1-dependent genes increased VSV infection. …”
Publicado 2019
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20307por Basavaraja, Raghavendra, Madusanka, Senasige Thilina, Drum, Jessica N., Shrestha, Ketan, Farberov, Svetlana, Wiltbank, Milo C., Sartori, Roberto, Meidan, Rina“…Recombinant ovine IFNT (roIFNT) induced the IFN-stimulated genes (ISGs; MX2, ISG15, and OAS1Y). IFNT induced a rapid and transient (15–45 min) phosphorylation of STAT1, while total STAT1 protein was higher only after 24 h. …”
Publicado 2019
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20308por Liu, Shenhe, Yue, Tingting, Ahmad, Muhammad Jamil, Hu, Xiangwei, Zhang, Xinxin, Deng, Tingxian, Hu, Yan, He, Changjiu, Zhou, Yang, Yang, Liguo“…Importantly, several hub genes (OAS2, MX2, IFIT5 and TGFB2) were significantly enriched in immune effector process. …”
Publicado 2020
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20309por Harenberg, Anke, Guillaume, Florine, Ryan, Elizabeth J., Burdin, Nicolas, Spada, Franca“…Many downstream type I interferon activated genes with anti-viral activity (PKR, Mx, ISG15 and OAS among others) were also up-regulated in response to ALVAC. …”
Publicado 2008
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20310“…Furthermore, in a time course study, a significant increase was noted in the expression of TLR3, TLR7, interferon (IFN)-α, IFN-β, interleukin (IL)-1β, IL-6 as well as 2′,5′-OAS in splenocytes treated with poly-UG. In conclusion, the present study demonstrated the immunostimulatory properties of dsRNA oligonucleotides, especially those that contain a poly-UG motif, in chickens.…”
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20311por Marklund, Marie“…PURPOSE: Occlusal changes are common during long-term treatment with oral appliances (OAs) for sleep apnea. The aim of the present study was to compare subjectively reported bite changes with objective findings. …”
Publicado 2019
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20312por Tirumurugaan, Krishnaswamy Gopalan, Pawar, Rahul Mohanchandra, Dhinakar Raj, Gopal, Thangavelu, Arthanari, Hammond, John A., Parida, Satya“…In both species, this included the interferon stimulated genes (ISGs) IFI44, IFI6, IFIT1, IFIT2, IFIT3, ISG15, Mx1, Mx2, OAS1X, RSAD2, IRF7, DDX58 and DHX58 that were transcribed significantly higher in cattle. …”
Publicado 2020
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20313por Chen, Yuming, Fan, Shuangqi, Zhao, Mengpo, Wu, Keke, Zhu, Erpeng, Ma, Shengming, He, Wencheng, Deng, Shaofeng, Xu, Hailuan, Zhang, Jingyuan, Ding, Hongxing, Yi, Lin, Zhao, Mingqiu, Chen, Jinding“…Besides, MG132 did not affect the expressions of IFN-α, STAT1, Mx1, OAS1, and PKR genes in cells without CSFV. In conclusion, we identify that MG132 significantly inhibits CSFV replication in vitro, in which the activation of the JAK-STAT pathway and the subsequent upregulation of expressions of ISGs might play significant roles, providing a potential preventive method for CSF.…”
Publicado 2020
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20314por Azamor, Tamiris, da Silva, Andréa Marques Vieira, Melgaço, Juliana Gil, dos Santos, Ana Paula, Xavier-Carvalho, Caroline, Alvarado-Arnez, Lucia Elena, Batista-Silva, Leonardo Ribeiro, de Souza Matos, Denise Cristina, Bayma, Camilla, Missailidis, Sotiris, Ano Bom, Ana Paula Dinis, Moraes, Milton Ozorio, da Costa Neves, Patrícia Cristina“…Following, seven DAV data showed activation of CD4(+) and CD8(+)T cells together with early positive correlations between type II IFN and genes of innate antiviral response (STAT1, STAT2, IRF7, IRF9, OAS1, and RNASEL) as well as antibody levels. Furthermore, individuals with genotypes rs2430561 AT/AA, rs2069718 AG/AA (IFNG), and rs13237944 AC/AA (CLEC5A), exhibited higher expression of IFNG and CLEC5A, respectively. …”
Publicado 2021
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20315por Bazan-Socha, Stanislawa, Buregwa-Czuma, Sylwia, Jakiela, Bogdan, Zareba, Lech, Zawlik, Izabela, Myszka, Aleksander, Soja, Jerzy, Okon, Krzysztof, Zarychta, Jacek, Kozlik, Paweł, Dziedzina, Sylwia, Padjas, Agnieszka, Wojcik, Krzysztof, Kepski, Michal, Bazan, Jan G.“…Additionally, RBM thickness correlated with the expression of genes encoding extracellular matrix (ECM) components (LAMA3, USH2A), involved in ECM remodeling (LTBP1), neovascularization (FGD5, HPRT1), nerve functioning (TPH1, PCDHGC4), oxidative stress adaptation (RIT1, HSP90AB1), epigenetic modifications (OLMALINC, DNMT3A), and the innate immune response (STAP1, OAS2). Cluster analysis revealed that genes linked with RBM thickness were also related to thicker bronchial walls in CT. …”
Publicado 2021
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20316por Jin, Kun, Qiu, Shi, Jin, Di, Zhou, Xianghong, Zheng, Xiaonan, Li, Jiakun, Liao, Xinyang, Yang, Lu, Wei, Qiang“…A prognostic signature based on 12 IRGs (MMP9, RBP7, ADIPOQ, AHNAK, OAS1, RAC3, SLIT2, EDNRA, IL34, PDGFD, PPY, IL17RD) performed moderately in prognostic predictions with area under the curve (AUC) equal to 0.76. …”
Publicado 2021
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20317“…According to multivariate Cox analysis, nine survival-related IRGs (MMP9, PDGFRA, AHNAK, OAS1, OLR1, RAC3, IGF1, PGF, and SH3BP2) were high-risk genes. …”
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20318por Sapiertein Silva, Juliana Feiman, Ferreira, Gustavo Fernandes, Perosa, Marcelo, Nga, Hong Si, de Andrade, Luis Gustavo Modelli“…METHODS: A retrospective cohort study including data of patients registered, between January 1, 2000 and December 31, 2017, in the waiting list of São Paulo State Organ Allocation System (SP-OAS) /Brazil. Data were randomly divided into two groups: 75% for training and 25% for testing. …”
Publicado 2021
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20319por Lu, Yingjuan, Yan, Yongcong, Li, Bowen, Liu, Mo, Liang, Yancan, Ye, Yushan, Cheng, Weiqi, Li, Jinsong, Jiao, Jiuyang, Chang, Shaohai“…We identified 10 prognosis-related hub RBPs (ZC3H12D, OAS2, INTS10, ACO1, PCBP4, RNASE3, PTGES3L-AARSD1, RNASE13, DDX4, and PCF11) and effectively predicted the overall survival of OSCC patients. …”
Publicado 2021
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20320por Ukleja-Sokołowska, Natalia, Zacniewski, Robert, Lis, Kinga, Żbikowska-Gotz, Magdalena, Kuźmiński, Andrzej, Bartuzi, Zbigniew“…Most (65–72%) of the patients who are allergic to kiwi report symptoms of an oral allergy syndrome (OAS); however, systemic manifestations (18–28%) have also been reported. …”
Publicado 2021
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