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  1. 2361
    “…However, their role in the pathogenesis of osteoarthritis (OA) or rheumatoid arthritis (RA) still remains broadly unknown. …”
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    Characterization of multinucleated giant cells in synovium and subchondral bone in knee osteoarthritis and rheumatoid arthritis
  2. 2362
    “…BACKGROUND: We examined the effects of fat deposition on radiographic osteoarthritis (OA) to determine the role of obesity in the pathogenesis of radiographic OA. …”
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    Associations between body composition measurements of obesity and radiographic osteoarthritis in older adults: Data from the Dong-gu Study
  3. 2363
    “…BACKGROUND: Studies of angiotensin-converting enzyme insertion/deletion (ACE I/D) polymorphisms and the risks of knee osteoarthritis (OA) have yielded conflicting results. OBJECTIVE: To determine the association between ACE I/D and knee OA, we conducted a combined case-control study and meta-analysis. …”
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    Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism and Susceptibility to Osteoarthritis of the Knee: A Case-Control Study and Meta-Analysis
  4. 2364
    “…OBJECTIVE: Clinical and in vitro studies suggest that subchondral bone sclerosis due to abnormal osteoblasts (Ob) is involved in the progression and/or onset of osteoarthritis (OA). Human Ob isolated from sclerotic subchondral OA bone tissue show an altered phenotype, a decreased canonical Wnt/β-catenin signaling pathway (cWnt), and a reduced mineralization in vitro. …”
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    Alteration of Wnt5a expression and of the non-canonical Wnt/PCP and Wnt/PKC-Ca(2+) pathways in human osteoarthritis osteoblasts
  5. 2365
    “…OA participants completed a washout of their usual medication. …”
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    Cold Pain Threshold Identifies a Subgroup of Individuals With Knee Osteoarthritis That Present With Multimodality Hyperalgesia and Elevated Pain Levels
  6. 2366
    “…OBJECTIVE: Osteoarthritis (OA) is a heterogeneous disease, and symptom progression at the foot is unclear. …”
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    Symptomatic Course of Foot Osteoarthritis Phenotypes: An 18‐Month Prospective Analysis of Community‐Dwelling Older Adults
  7. 2367
    “…A total of 30 male Sprague-Dawley rats were randomly divided into three groups (n=10), including the control, OA and OA with treadmill exercise (OAE) groups. …”
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    Alterations of autophagy in knee cartilage by treatment with treadmill exercise in a rat osteoarthritis model
  8. 2368
    “…The OA progressed subjects were divided to three groups: the “OA change group”, KL0 and KL1 knees that progressed to KL2 and KL3; the “mild change group”, KL2 knees that progressed to KL3; and the “severe change group”, KL2 and KL3 knees that progressed to KL4. …”
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    Stage-specific meniscal features predict progression of osteoarthritis of the knee: a retrospective cohort study using data from the osteoarthritis initiative
  9. 2369
    “…Photoacoustic-ultrasound imaging revealed a robust inhibition of liver steatosis and fibrosis by OA-NO(2). RNA-sequencing analysis uncovered inflammation and fibrosis as major pathways suppressed by OA-NO(2) administration, as well as regulation of lipogenesis and lipolysis pathways, with a robust inhibition of SREBP1 proteolytic activation and subsequent lipogenesis gene expression by OA-NO(2). …”
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    Nitro-fatty acids protect against steatosis and fibrosis during development of nonalcoholic fatty liver disease in mice
  10. 2370
    “…Alterations in synovial fluid (SF) lipid composition have been linked to both osteoarthritis (OA) and rheumatoid arthritis (RA). The aim of the present study was to compare the FA signatures in the IFP and SF of RA and OA patients. …”
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    Distinct fatty acid signatures in infrapatellar fat pad and synovial fluid of patients with osteoarthritis versus rheumatoid arthritis
  11. 2371
    “…Our objective was to identify molecules to prevent OA by regulating chondrocyte senescence and autophagy. …”
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    Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy
  12. 2372
    “…This review summarises the reported prevalence of PFJ OA and risk factors of PFJ OA after ACL injury. …”
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    Prevalence of patellofemoral joint osteoarthritis after anterior cruciate ligament injury and associated risk factors: A systematic review
  13. 2373
    “…BACKGROUND: Osteoarthritis (OA) is a multifactorial complex disease. The impact of plasma proteins on OA remains elusive now. …”
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    Assessing the genetic relationships between osteoarthritis and human plasma proteins: a large scale genetic correlation scan
  14. 2374
    “…RESULTS: The expression of FBXO6 decreased in the cartilage from human OA samples, anterior cruciate ligament transaction (ACLT) -induced OA samples, spontaneous OA STR/ort samples and aged mice samples. …”
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    TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination
  15. 2375
    “…BACKGROUND: Our preliminary RNA-Seq data revealed altered expression of small nucleolar RNA host gene 9 (SNHG9) in osteoarthritis (OA) and its reverse correlation with miR-34a, which can regulate chondrocyte apoptosis in rat OA model. …”
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    LncRNA SNHG9 is downregulated in osteoarthritis and inhibits chondrocyte apoptosis by downregulating miR-34a through methylation
  16. 2376
    por Schulze-Tanzil, Gundula
    Publicado 2021
    “…Osteoarthritis (OA) therapy remains a large challenge since no causative treatment options are so far available. …”
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    Experimental Therapeutics for the Treatment of Osteoarthritis
  17. 2377
    “…The dominant contributor of PM was organic aerosol (OA), and results of a hybrid environmental receptor model indicated OA was composed of four primary OA (POA) factors (hydrocarbon-like OA (HOA), cooking OA (COA), biomass burning OA (BBOA), and coal combustion OA (CCOA)) and two oxygenated OA (OOA) factors (less-oxidized OOA (LO-OOA) and more-oxidized OOA (MO-OOA)). …”
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    Impacts of primary emissions and secondary aerosol formation on air pollution in an urban area of China during the COVID-19 lockdown
  18. 2378
    “…BACKGROUND: Osteoarthritis (OA) is a worldwide musculoskeletal disorder. However, disease-modifying therapies for OA are not available. …”
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    Identification of key regulators responsible for dysregulated networks in osteoarthritis by large-scale expression analysis
  19. 2379
    “…Osteoarthritis (OA) is a chronic degenerative musculoskeletal disease that causes articular cartilage degeneration and chronic pain. …”
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    NGF Expression and Elevation in Hip Osteoarthritis Patients with Pain and Central Sensitization
  20. 2380
    “…BACKGROUND: Osteoarthritis (OA) is an important health issue in elderly people. …”
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    Genetic association between TNF-α G-308A and osteoarthritis in Asians: A case–control study and meta-analysis
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