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  1. 2381
    “…Anthropogenic elevation of atmospheric carbon dioxide (CO(2)) drives global-scale ocean acidification (OA), which has aroused widespread concern for marine ecosystem health. …”
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    Effects of Ocean Acidification on Molting, Oxidative Stress, and Gut Microbiota in Juvenile Horseshoe Crab Tachypleus tridentatus
  2. 2382
    “…OBJECTIVE: We explored the effect of SenA on IL-1β-stimulated chondrocytes and OA mice MATERIALS AND METHODS: Chondrocytes were stimulated by IL-1β (10 ng/mL) to establish an OA model in vitro. …”
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    Senkyunolide A inhibits the progression of osteoarthritis by inhibiting the NLRP3 signalling pathway
  3. 2383
    “…Dietary fatty acid (FA) content and type have different effects on obesity-associated osteoarthritis (OA), but the mechanisms underlying these differences are not fully understood. …”
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    Dietary Fatty Acid Regulation of the NLRP3 Inflammasome via the TLR4/NF-κB Signaling Pathway Affects Chondrocyte Pyroptosis
  4. 2384
    “…A previous multicentral randomized clinical trial has shown that GBT can effectively relieve joint pain and improve quality of life with a high safety in treating osteoarthritis (OA). This study is aimed at elucidating the active compounds, potential targets, and mechanisms of GBT for treating OA. …”
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    Integrating Network Pharmacology and Experimental Validation to Explore the Key Mechanism of Gubitong Recipe in the Treatment of Osteoarthritis
  5. 2385
    “…Patients with codified knee OA were selected, and an algorithm was developed to identify patients with narratively diagnosed knee OA only. …”
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    Incidence and Prevalence of Knee Osteoarthritis Using Codified and Narrative Data From Electronic Health Records: A Population‐Based Study
  6. 2386
    “…This study aimed to investigate the effect of celastrol on OA as well as the mechanisms in vivo and in vitro. …”
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    Celastrol ameliorates osteoarthritis via regulating TLR2/NF-κB signaling pathway
  7. 2387
    “…PURPOSE: This study aimed to investigate the effect of medial open wedge high tibial osteotomy (MOWHTO) on patellofemoral joint osteoarthritis (PF OA) progression and its outcome according to the degree of preexisting PF OA. …”
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    Effect of medial open wedge high tibial osteotomy on progression of patellofemoral osteoarthritis
  8. 2388
    “…Osteoarthritis (OA) is a degenerative joint disorder causing pain and functional disability. …”
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    CircFOXO3 protects against osteoarthritis by targeting its parental gene FOXO3 and activating PI3K/AKT-mediated autophagy
  9. 2389
    “…BACKGROUND: Few studies have been reported the potential role of N6-methyladenosine (m(6)A) modification in osteoarthritis (OA). We investigated the patterns of m(6)A modification in the immune microenvironment of OA. …”
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    Characterization of immune microenvironment infiltration and m(6)A regulator-mediated RNA methylation modification patterns in osteoarthritis
  10. 2390
    “…Gut microbiome (GMB) disturbance can induce chronic low-grade inflammation, which is closely related to the occurrence and development of osteoarthritis (OA). However, the relationship between GMB and OA remains unclear. …”
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    Analysis of gut microbiome composition, function, and phenotype in patients with osteoarthritis
  11. 2391
    “…In vitro, these L-M2a macrophages were treated with OA synovial fluid or co-cultured with OA chondrocytes or fibroblast-like synoviocytes (FLS). …”
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    Engineered M2a macrophages for the treatment of osteoarthritis
  12. 2392
    “…Knee osteoarthritis (OA) is the most common joint disease worldwide. …”
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    High-Intensity Training for Knee Osteoarthritis: A Narrative Review
  13. 2393
    “…Osteoarthritis (OA) is a common disease characterized by severe chronic joint pain, that imposes a large burden on elderly people. …”
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    Sirtuins in osteoarthritis: current understanding
  14. 2394
    “…The treatment of OA is diversified, mostly limited to relieving clinical symptoms. …”
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    The Role of Cartilage Stem/Progenitor Cells in Cartilage Repair in Osteoarthritis
  15. 2395
    “…Osteoarthritis (OA) is a multifactorial disease in which genetics, aging, obesity, and trauma are well-known risk factors. …”
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    The Role of Alarmins in Osteoarthritis Pathogenesis: HMGB1, S100B and IL-33
  16. 2396
    “…We have studied the cyclodextrin-encapsulated form of OA with OA/DMSO, comparing their stability, biological properties for cell migration, and cell viability. …”
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    Oleanolic Acid Complexation with Cyclodextrins Improves Its Cell Bio-Availability and Biological Activities for Cell Migration
  17. 2397
    por Zhang, Yanlei, Ji, Quanbo
    Publicado 2023
    “…Osteoarthritis (OA) is one of the leading causes of pain and disability in the elderly. …”
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    Macrophage polarization in osteoarthritis progression: a promising therapeutic target
  18. 2398
    “…The increased prevalence of OA with aging, coupled to the demographics of aging populations, make OA a high priority health care problem. …”
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    Hylan G-F 20: Review of its Safety and Efficacy in the Management of Joint Pain in Osteoarthritis
  19. 2399
    “…Both men and women with knee-OA had lower ankle propulsion mechanical work expenditure (MWE; P < .001 for both) and higher hip generative MWE (P < .001) compared to non-OA controls. …”
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    Sex-Specific Gait Patterns of Older Adults with Knee Osteoarthritis: Results from the Baltimore Longitudinal Study of Aging
  20. 2400
    “…There is currently no effective drug treatment for the early phase of osteoarthritis (OA), one of the most common senile diseases. The goal of this study was to investigate the protective effect of the tetrandrine (Tet) on OA, in vitro and in vivo. …”
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    Tetrandrine Inhibits the Wnt/β-Catenin Signalling Pathway and Alleviates Osteoarthritis: An In Vitro and In Vivo Study
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