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  1. 2701
    “…Osteoarthritis (OA) is a common, painful and debilitating disease of articulating joints resulting from the age-associated loss of cartilage. …”
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    Methylation quantitative trait locus analysis of osteoarthritis links epigenetics with genetic risk
  2. 2702
    “…OBJECTIVE: With no effective therapies to attenuate cartilage degeneration in osteoarthritis (OA), the result is pain and disability. Activation of hedgehog (HH) signaling causes changes related to the progression of OA, with higher levels of Gli‐mediated transcriptional activation associated with increased disease severity. …”
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    Regulation of Cholesterol Homeostasis by Hedgehog Signaling in Osteoarthritic Cartilage
  3. 2703
    “…To examine the relationship between serum calcium (Ca) concentration and radiographic knee osteoarthritis (OA). This study covered a total of 2855 subjects. …”
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    Serum Calcium Concentration Is Inversely Associated With Radiographic Knee Osteoarthritis: A Cross-Sectional Study
  4. 2704
    “…Ocean acidification (OA) is expected to indirectly impact biota living in contaminated coastal environments by altering the bioavailability and potentially toxicity of many pH-sensitive metals. …”
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    Ocean acidification increases copper toxicity differentially in two key marine invertebrates with distinct acid-base responses
  5. 2705
    “…PURPOSE: The aim of this study was to determine the relationship of hypoxia-inducible factor-2 (HIF-2α) and vascular endothelial growth factor (VEGF) with radiographic severity in primary osteoarthritis (OA) of the knee. Expression of these two factors in cartilage samples from OA knee joints was examined at mRNA and protein levels. …”
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    The Relationship between HIF-2α and VEGF with Radiographic Severity in the Primary Osteoarthritic Knee
  6. 2706
    “…OBJECTIVE(S): Osteoarthritis (OA), as a known degenerative joint disease, is the most common form of arthritis. …”
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    Effects of estradiol on reduction of osteoarthritis in rabbits through effect on matrix metalloproteinase proteins
  7. 2707
    “…BACKGROUND: Plain radiography is the first choice for diagnosis and monitoring of knee-osteoarthritis (OA) while, Kellgren–Lawrence score (KL) is most widely used to grade OA severity. …”
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    Glycosaminoglycan measured from synovial fluid serves as a useful indicator for progression of Osteoarthritis and complements Kellgren–Lawrence Score
  8. 2708
    “…Defining the role of mechanosensory pathways in cartilage during OA pathogenesis may yield novel strategies or targets for the treatment of OA. …”
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    Cartilage-Specific Knockout of the Mechanosensory Ion Channel TRPV4 Decreases Age-Related Osteoarthritis
  9. 2709
    “…Although the association between depressive disorders and osteoarthritis (OA) has been studied, the association of other psychiatric disorders with OA remains unclear. …”
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    Association between psychiatric disorders and osteoarthritis: a nationwide longitudinal population-based study
  10. 2710
    “…Transforming growth factor alpha (TGFα) is a growth factor involved in osteoarthritis (OA). TGFα induces an OA-like phenotype in articular chondrocytes, by inhibiting matrix synthesis and promoting catabolic factor expression. …”
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    Context-specific protection of TGFα null mice from osteoarthritis
  11. 2711
    “…BACKGROUND: Among the chronic rheumatic diseases, hip and knee osteoarthritis (OA) is the most prevalent and is a leading cause of pain and disability in most countries worldwide. …”
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    Epidemiology of knee osteoarthritis in India and related factors
  12. 2712
    “…Osteoarthritis (OA) mainly affects older populations; however, it is possible that early life factors contribute to the development of OA in later life. …”
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    Do early life factors affect the development of knee osteoarthritis in later life: a narrative review
  13. 2713
    “…Osteoarthritis (OA) is one of the most common diseases around the world. …”
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    New developments in the treatment of osteoarthritis – focus on biologic agents
  14. 2714
    “…This study reports the effects of the iron chelator deferoxamine (DFO) on collagen cleavage, inflammation, and chondrocyte hypertrophy in relation to energy metabolism-related gene expression in osteoarthritic (OA) articular cartilage. Full-depth explants of human OA knee articular cartilage from arthroplasty were cultured with exogenous DFO (1–50 μM). …”
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    Deferoxamine Suppresses Collagen Cleavage and Protease, Cytokine, and COL10A1 Expression and Upregulates AMPK and Krebs Cycle Genes in Human Osteoarthritic Cartilage
  15. 2715
    “…The prevalence of primary or idiopathic osteoarthritis (OA) of knee and hip joints has substantially increased in general population during the last decades. …”
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    Glucosamine and chondroitin for the treatment of osteoarthritis
  16. 2716
    “…Currently there are no sufficiently sensitive biomarkers able to reflect changes in joint remodelling during osteoarthritis (OA). In this work, we took an affinity proteomic approach to profile serum samples for proteins that could serve as indicators for the diagnosis of radiographic knee OA. …”
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    Discovery of circulating proteins associated to knee radiographic osteoarthritis
  17. 2717
    “…OA-like pain behavior was tested using the dynamic weight bearing. …”
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    Expression of matrix metalloproteinases and components of the endocannabinoid system in the knee joint are associated with biphasic pain progression in a rat model of osteoarthritis
  18. 2718
    “…PURPOSE: The purpose of this study is to test the hypothesis that a flexible oral appliance without incisor coverage (OA(Flex)) increases the irregularity of the front teeth compared with a rigid appliance with incisor coverage (OA(Rigid)) in patients treated for obstructive sleep apnea (OSA). …”
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    Changes in lower incisor irregularity during treatment with oral sleep apnea appliances
  19. 2719
    por Park, Clara Yongjoo
    Publicado 2017
    “…Breastfeeding is associated with many health benefits to the mother but the association between osteoarthritis (OA) is not known. Menopause, a state of rapid estrogen loss, is associated with OA. …”
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    Breastfeeding for One Month or Longer is Associated with Higher Risk of Osteoarthritis in Older Adults: NHANES 1999–2012
  20. 2720
    “…Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage degradation and inflammation. …”
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    Silibinin protects against osteoarthritis through inhibiting the inflammatory response and cartilage matrix degradation in vitro and in vivo
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