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2701por Rushton, Michael D., Reynard, Louise N., Young, David A., Shepherd, Colin, Aubourg, Guillaume, Gee, Fiona, Darlay, Rebecca, Deehan, David, Cordell, Heather J., Loughlin, John“…Osteoarthritis (OA) is a common, painful and debilitating disease of articulating joints resulting from the age-associated loss of cartilage. …”
Publicado 2015
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2702por Ali, Shabana Amanda, Al‐Jazrawe, Mushriq, Ma, Henry, Whetstone, Heather, Poon, Raymond, Farr, Sarah, Naples, Mark, Adeli, Khosrow, Alman, Benjamin A.“…OBJECTIVE: With no effective therapies to attenuate cartilage degeneration in osteoarthritis (OA), the result is pain and disability. Activation of hedgehog (HH) signaling causes changes related to the progression of OA, with higher levels of Gli‐mediated transcriptional activation associated with increased disease severity. …”
Publicado 2016
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2703por Li, Hui, Zeng, Chao, Wei, Jie, Yang, Tuo, Gao, Shu-Guang, Li, Yu-Sheng, Luo, Wei, Xiao, Wen-Feng, Xiong, Yi-Lin, Lei, Guang-Hua“…To examine the relationship between serum calcium (Ca) concentration and radiographic knee osteoarthritis (OA). This study covered a total of 2855 subjects. …”
Publicado 2016
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2704por Lewis, Ceri, Ellis, Robert P., Vernon, Emily, Elliot, Katie, Newbatt, Sam, Wilson, Rod W.“…Ocean acidification (OA) is expected to indirectly impact biota living in contaminated coastal environments by altering the bioavailability and potentially toxicity of many pH-sensitive metals. …”
Publicado 2016
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2705por Jian-lin, Zhou, Hong-song, Fang, Hao, Peng, Shuang, Deng, Shen, Chen, Jian-ping, Li, Bo, Qiu, Jin-qing, Weng, Feng, Liu“…PURPOSE: The aim of this study was to determine the relationship of hypoxia-inducible factor-2 (HIF-2α) and vascular endothelial growth factor (VEGF) with radiographic severity in primary osteoarthritis (OA) of the knee. Expression of these two factors in cartilage samples from OA knee joints was examined at mRNA and protein levels. …”
Publicado 2016
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2706por Wang, Weiguo, Wang, Lin, Xu, Zhanwang, Yin, Yanxia, Su, Jun, Niu, Xiufeng, Cao, Xuecheng“…OBJECTIVE(S): Osteoarthritis (OA), as a known degenerative joint disease, is the most common form of arthritis. …”
Publicado 2016
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2707por Kulkarni, Priya, Deshpande, Shantanu, Koppikar, Soumya, Patil, Sanjay, Ingale, Dhanashri, Harsulkar, Abhay“…BACKGROUND: Plain radiography is the first choice for diagnosis and monitoring of knee-osteoarthritis (OA) while, Kellgren–Lawrence score (KL) is most widely used to grade OA severity. …”
Publicado 2016
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2708por O’Conor, Christopher J., Ramalingam, Sendhilnathan, Zelenski, Nicole A., Benefield, Halei C., Rigo, Isaura, Little, Dianne, Wu, Chia-Lung, Chen, Di, Liedtke, Wolfgang, McNulty, Amy L., Guilak, Farshid“…Defining the role of mechanosensory pathways in cartilage during OA pathogenesis may yield novel strategies or targets for the treatment of OA. …”
Publicado 2016
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2709por Huang, Shih-Wei, Wang, Wei-Te, Lin, Li-Fong, Liao, Chun-De, Liou, Tsan-Hon, Lin, Hui-Wen“…Although the association between depressive disorders and osteoarthritis (OA) has been studied, the association of other psychiatric disorders with OA remains unclear. …”
Publicado 2016
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2710por Usmani, Shirine E., Ulici, Veronica, Pest, Michael A., Hill, Tracy L., Welch, Ian D., Beier, Frank“…Transforming growth factor alpha (TGFα) is a growth factor involved in osteoarthritis (OA). TGFα induces an OA-like phenotype in articular chondrocytes, by inhibiting matrix synthesis and promoting catabolic factor expression. …”
Publicado 2016
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2711por Pal, Chandra Prakash, Singh, Pulkesh, Chaturvedi, Sanjay, Pruthi, Kaushal Kumar, Vij, Ashok“…BACKGROUND: Among the chronic rheumatic diseases, hip and knee osteoarthritis (OA) is the most prevalent and is a leading cause of pain and disability in most countries worldwide. …”
Publicado 2016
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2712“…Osteoarthritis (OA) mainly affects older populations; however, it is possible that early life factors contribute to the development of OA in later life. …”
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2713“…Osteoarthritis (OA) is one of the most common diseases around the world. …”
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2714por Tchetina, Elena V., Markova, Galina A., Poole, A. Robin, Zukor, David J., Antoniou, John, Makarov, Sergey A., Kuzin, Aleksandr N.“…This study reports the effects of the iron chelator deferoxamine (DFO) on collagen cleavage, inflammation, and chondrocyte hypertrophy in relation to energy metabolism-related gene expression in osteoarthritic (OA) articular cartilage. Full-depth explants of human OA knee articular cartilage from arthroplasty were cultured with exogenous DFO (1–50 μM). …”
Publicado 2016
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2715“…The prevalence of primary or idiopathic osteoarthritis (OA) of knee and hip joints has substantially increased in general population during the last decades. …”
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2716por Lourido, Lucía, Ayoglu, Burcu, Fernández-Tajes, Juan, Oreiro, Natividad, Henjes, Frauke, Hellström, Cecilia, Schwenk, Jochen M., Ruiz-Romero, Cristina, Nilsson, Peter, Blanco, Francisco J.“…Currently there are no sufficiently sensitive biomarkers able to reflect changes in joint remodelling during osteoarthritis (OA). In this work, we took an affinity proteomic approach to profile serum samples for proteins that could serve as indicators for the diagnosis of radiographic knee OA. …”
Publicado 2017
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2717por Pajak, Agnieszka, Kostrzewa, Magdalena, Malek, Natalia, Korostynski, Michal, Starowicz, Katarzyna“…OA-like pain behavior was tested using the dynamic weight bearing. …”
Publicado 2017
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2718“…PURPOSE: The purpose of this study is to test the hypothesis that a flexible oral appliance without incisor coverage (OA(Flex)) increases the irregularity of the front teeth compared with a rigid appliance with incisor coverage (OA(Rigid)) in patients treated for obstructive sleep apnea (OSA). …”
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2719por Park, Clara Yongjoo“…Breastfeeding is associated with many health benefits to the mother but the association between osteoarthritis (OA) is not known. Menopause, a state of rapid estrogen loss, is associated with OA. …”
Publicado 2017
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2720por Zheng, Wenhao, Feng, Zhenhua, Lou, Yiting, Chen, Chunhui, Zhang, Chuanxu, Tao, Zhenyu, Li, Hang, Cheng, Liang, Ying, Xiaozhou“…Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage degradation and inflammation. …”
Publicado 2017
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