“…Increasing evidence indicates that long non-coding RNAs (lncRNAs) play critical roles in osteoarthritis (OA). The present study aimed to investigate the underlying molecular mechanism of lncRNA musculin antisense RNA 1 (MSC-AS1) in OA. …”
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“…Although the mechanism of osteoarthritis (OA) has been widely studied and the use of quercetin for OA therapy is well documented, the relevant characteristics of the microbiome and metabolism remain unclear. …”
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“…Further, while there were no differences in the CD14+ fraction between RA and OA, MINCLE expression in the CD14– fraction was elevated in RA compared to OA. …”
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“…Depression, one of the most common comorbidities with osteoarthritis (OA), affects patient prognosis and quality of life. …”
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“…OBJECTIVE: To investigate whether the first wave of the COVID-19 pandemic impacted healthcare consultations (HCC) and hospitalization among people with and without osteoarthritis (OA). METHODS: Using register data, we included individuals aged ≥35 years residing in Skåne region, Sweden, during 2009–2019 with (n ​= ​123,523) and without (n ​= ​552,412) a diagnosis of OA during January 1, 2009–December 31, 2019. …”
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“…Here, we demonstrate that the MT(1) melatonin receptor, but not the MT(2) receptor, is highly expressed in normal tissue and only minimally in OA tissue. By targeting the MT(1) receptor, melatonin reversed OA-induced pathology and effectively reduced levels of TNF-α, IL-8, and VEGF expression in OA synovial fibroblasts and synovium from rats with severe OA. …”
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“…BACKGROUND: Osteoarthritis (OA) is one of the most common joint disorders and debilitating diseases. …”
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“…The current pharmaceutical treatment of OA is limited to the slight alleviation of symptoms (e.g., local injection of hyaluronic acid or non-steroidal anti-inflammatory drugs); hence, the development of effective drugs and regenerative therapies for OA is highly desirable. …”
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“…The use of OA has significantly reduced the production of IL-8, 10 at 9th day. …”
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“…Osteoarthritis (OA) is a risk factor for falls. To decrease the fall risk, it is important to evaluate the detailed features of the gait of patients with OA. …”
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“…The current treatment for early OA is focused on the relief of symptoms, such as pain, but this treatment cannot delay the pathological process. …”
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“…In this review, we put forward the proposition that greater focus on rarer forms of OA could lead to a better understanding of the pathogenesis of more common OA. …”
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“…RESULTS: The sample included 95,605 publications; 94.1% were published in an OA form, 44% of which were published as Bronze OA. …”
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“…OBJECTIVE: This study aims to increase the understanding of pain mechanisms in hand OA and explore potential risk factors for pain development or worsening in a biopsychosocial framework. …”
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“…For (i), we analysed the association between starting NSAIDs and the risk of incident outcome events in the 6 years following NSAID dispensation among people with prevalent OA vs no OA. For (ii) we studied the effect of discontinuing NSAIDs among people with and without OA up to 120 days. …”
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“…CONCLUSION: This study uniquely interviewed GPs and surgeons from the same population, capturing two crucial areas of OA management. Some key barriers to treatment were identified and options for improving treatment include creating opportunities for increased patient education about OA, enhanced accessibility to OA conservative management programs along with improved reimbursement models supporting conservative management as first-line OA treatment.…”
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“…OBJECTIVE: In previous studies, we determined an association between increased serum and articular cartilage levels of CCL2 with osteoarthritis (OA) progression, cartilage damage and increased MMP13 in cartilage. …”
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“…OBJECTIVES: Symptomatic knee osteoarthritis (OA) commonly co-exists in persons with Type 2 diabetes (T2DM) and may impede diabetes self-management. …”
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“…Enhancement in joint groups in erosive hand OA vs. RA was compared using Mann-Whitney test. …”
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“…Background: Nurses face the risk of new onset occupational asthma (OA) due to exposures to cleaning and disinfection (C&D) agents used to prevent infections in healthcare facilities. …”
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