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2821“…A central feature of osteoarthritis (OA) is the loss of articular cartilage, which is primarily attributed to cartilage breakdown. …”
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2822por Won, Yoonkyung, Shin, Youngnim, Chun, Churl-Hong, Cho, Yongsik, Ha, Chul-Won, Kim, Jin-Hong, Chun, Jang-Soo“…OBJECTIVE: The zinc-ZIP8-MTF1 axis induces metallothionein (MT) expression and is a catabolic regulator of experimental osteoarthritis (OA) in mice. The main aim of the current study was to explore the roles and underlying molecular mechanisms of MTs in OA pathogenesis. …”
Publicado 2016
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2823por Kohno, Yuji, Mizuno, Mitsuru, Ozeki, Nobutake, Katano, Hisako, Komori, Keiichiro, Fujii, Shizuka, Otabe, Koji, Horie, Masafumi, Koga, Hideyuki, Tsuji, Kunikazu, Matsumoto, Mikio, Kaneko, Haruka, Takazawa, Yuji, Muneta, Takeshi, Sekiya, Ichiro“…RESULTS: Nucleated cell number per 1 mg synovium was 8.4 ± 3.9 thousand in RA and 8.0 ± 0.9 thousand in OA. Total cell number after 14-day culture/1 mg synovium was 0.7 ± 0.4 million in RA and 0.5 ± 0.3 million in OA, showing no significant difference between in RA and OA. …”
Publicado 2017
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2824por Britti, Domenico, Crupi, Rosalia, Impellizzeri, Daniela, Gugliandolo, Enrico, Fusco, Roberta, Schievano, Carlo, Morittu, Valeria Maria, Evangelista, Maurizio, Di Paola, Rosanna, Cuzzocrea, Salvatore“…BACKGROUND: Osteoarthritis (OA) is a common progressive joint disease in dogs and cats. …”
Publicado 2017
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2825por Smith, Elise, Haustein, Stefanie, Mongeon, Philippe, Shu, Fei, Ridde, Valéry, Larivière, Vincent“…Our study aims to assess the use, cost and impact of OA diffusion in the context of GHR. METHOD: A total of 3366 research articles indexed under the Medical Heading Subject Heading “Global Health” published between 2010 and 2014 were retrieved using PubMed to (1) quantify the uptake of various types of OA, (2) estimate the article processing charges (APCs) of OA, and (3) analyse the relationship between different types of OA, their scholarly impact and gross national income per capita of citing countries. …”
Publicado 2017
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2826por Liu, Chenglei, Liu, Chang, Ren, Xvhua, Si, Liping, Shen, Hao, Wang, Qian, Yao, Weiwu“…BACKGROUND: Osteoarthritis (OA) is now increasingly recognized as being related to the whole joint instead of the cartilage alone. …”
Publicado 2017
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2827por Wang, Honglin, Zhang, Xu, Wu, Wentao, Zhang, Mingyue, Sam, Napoleon Bellua, Niu, Lei“…OBJECTIVES: Association between the D-repeat of asporin (ASPN) gene and osteoarthritis (OA) was still inconsistent. We performed this meta-analysis to systematically assess the D-repeat polymorphisms in OA susceptibility. …”
Publicado 2018
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2828por Deroyer, Céline, Charlier, Edith, Neuville, Sophie, Malaise, Olivier, Gillet, Philippe, Kurth, William, Chariot, Alain, Malaise, Michel, de Seny, Dominique“…To this end, CEMIP, αSMA and types I and III collagen expressions were assessed in human OA and non-OA cartilage. CEMIP expression was also investigated in a mouse OA model. …”
Publicado 2019
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2829por Vansteenkiste, Daniella, Martin-Vaquero, Paula, Bonelli, Marília, da Costa, Luciana B., da Costa, Ronaldo C.“…BACKGROUND: Osseous- associated cervical spondylomyelopathy (OA-CSM) has a high prevalence in Great Danes. In order to understand the progression of osseous changes, we aimed to perform a long-term computed tomographic (CT) follow-up study of Great Dane dogs with and without OA-CSM. …”
Publicado 2019
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2830por Nasi, Sonia, Ehirchiou, Driss, Chatzianastasiou, Athanasia, Nagahara, Noriyuki, Papapetropoulos, Andreas, Bertrand, Jessica, Cirino, Giuseppe, So, Alexander, Busso, Nathalie“…BACKGROUND: Osteoarthritis (OA) is characterized by the formation and deposition of calcium-containing crystals in joint tissues, but the underlying mechanisms are poorly understood. …”
Publicado 2020
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2831“…Implantation of phenotypically superior OA chondrocytes in collagen I scaffolds at high density could be a promising tool for the treatment of elderly OA patients.…”
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2832por Chen, Chung-Hwan, Kuo, Shyh Ming, Tien, Yin-Chun, Shen, Po-Chih, Kuo, Yi-Wen, Huang, Han Hsiang“…Low-intensity pulsed ultrasound (LIPUS) has been found to possess anti-OA effects. MATERIALS AND METHODS: The anti-osteoarthritic effects of liposome-encapsulated rapamycin (L-rapa) combined with LIPUS were examined by culture of normal and OA chondrocytes in alginate beads and further validated in OA prone Dunkin-Hartley guinea pigs. …”
Publicado 2020
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2833por Haugen, Ida K, Felson, David T, Abhishek, Abhishek, Berenbaum, Francis, Bierma-Zeinstra, Sita, Borgen, Tove, Herrero Beaumont, Gabriel, Ishimori, Mariko, Jonsson, Helgi, Kroon, Féline PB, Maheu, Emmanuel, Ramonda, Roberta, Ritschl, Valentin, Stamm, Tanja A, van der Heijde, Desirée, Wittoek, Ruth, Greibrokk, Elsie, Smeets, Wilma, Kloppenburg, Margreet“…OBJECTIVES: Further knowledge about typical hand osteoarthritis (OA) characteristics is needed for the development of new classification criteria for hand OA. …”
Publicado 2020
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2834por Teo, Pek Ling, Bennell, Kim L, Lawford, Belinda, Egerton, T, Dziedzic, Krysia, Hinman, Rana S“…OBJECTIVE: Physiotherapists commonly provide non-surgical care for people with knee osteoarthritis (OA). It is unknown if patients are receiving high-quality physiotherapy care for their knee OA. …”
Publicado 2021
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2835por Hartley, April, Sanderson, Eleanor, Paternoster, Lavinia, Teumer, Alexander, Kaplan, Robert C, Tobias, Jon H, Gregson, Celia L“…OBJECTIVES: How insulin-like growth factor-1 (IGF-1) is related to OA is not well understood. We determined relationships between IGF-1 and hospital-diagnosed hand, hip and knee OA in UK Biobank, using Mendelian randomization (MR) to determine causality. …”
Publicado 2020
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2836por Pyun, Jung-Min, Ryu, Ji Sun, Lee, Ryan, Shim, Kyu Hawn, Youn, Young Chul, Ryoo, Nayoung, Han, Sang-Won, Park, Young Ho, Kang, Sungmin, An, Seong Soo A, Kim, SangYun“…PURPOSE: Among other emerging amyloid-targeting blood-based biomarkers, Multimer Detection System-Oligomeric Amyloid-β (MDS-OAβ) measures dynamic changes in concentration of oligomeric amyloid-β (OAβ), which is considered the main pathogenic culprit of Alzheimer’s disease (AD), in plasma after spiking with synthetic amyloid-β (Aβ). …”
Publicado 2021
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2837por Mimpen, Jolet Y., Baldwin, Mathew J., Cribbs, Adam P., Philpott, Martin, Carr, Andrew J., Dakin, Stephanie G., Snelling, Sarah J.B.“…Increased interleukin (IL)-17A has been identified in joints affected by osteoarthritis (OA), but it is unclear how IL-17A, and its family members IL-17AF and IL-17F, can contribute to human OA pathophysiology. …”
Publicado 2021
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2838por Fallach, Noga, Chodick, Gabriel, Tirosh, Matanya, Eisenberg, Elon, Lubovsky, Omri“…RESULTS: A total of 180,126 OA patients were included in our analyses; analgesics were dispensed to 64.2% of the patients, with oral NSAIDs and opioids dispensed to 34.1 and 22.9% of the OA population, respectively. …”
Publicado 2021
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2839por Haugen, Ida K, Felson, David, Abhishek, Abhishek, Berenbaum, Francis, Edwards, John James, Herrero Beaumont, Gabriel, Hermann-Eriksen, Merete, Hill, Catherine L, Ishimori, Mariko, Jonsson, Helgi, Karjalainen, Teemu, Leung, Ying Ying, Maheu, Emmanuel, Mallen, Christian D, Moe, Rikke Helene, Ramonda, Roberta, Ritschl, Valentin, Stamm, Tanja A, Szekanecz, Zoltan, van der Giesen, Florus J, Ritt, Marco J P F, Wittoek, Ruth, Kjeken, Ingvild, Osteras, Nina, van de Stadt, Lotte A, Englund, Martin, Dziedzic, Krysia S, Marshall, M, Bierma-Zeinstra, Sita, Hansen, Paul, Greibrokk, Elsie, Smeets, Wilma, Kloppenburg, Margreet“…OBJECTIVES: In Phase 1 of developing new hand osteoarthritis (OA) classification criteria, features associated with hand OA were identified in a population with hand complaints. …”
Publicado 2022
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2840por Drvar, Vedrana, Ćurko-Cofek, Božena, Karleuša, Ljerka, Aralica, Merica, Rogoznica, Marija, Kehler, Tatjana, Legović, Dalen, Rukavina, Daniel, Laskarin, Gordana“…Osteoarthritis (OA) is a chronic joint disease caused by mechanical damage and metabolic factors that support the development of low-grade inflammation. …”
Publicado 2022
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