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  1. 2981
    “…The association between osteoarthritis (OA) and gastrointestinal disorders was found in observational studies. …”
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    Assessing causality between osteoarthritis and gastrointestinal disorders: a Mendelian randomization study
  2. 2982
    “…While morphologic and biochemical aspects of degenerative joint disease (osteoarthritis [OA]) have been elucidated by numerous studies, the molecular mechanisms underlying the progressive loss of articular cartilage during OA development remain largely unknown. …”
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    Early and stable upregulation of collagen type II, collagen type I and YKL40 expression levels in cartilage during early experimental osteoarthritis occurs independent of joint location and histological grading
  3. 2983
    “…Oxidative stress leads to increased risk for osteoarthritis (OA) but the precise mechanism remains unclear. We undertook this study to clarify the impact of oxidative stress on the progression of OA from the viewpoint of oxygen free radical induced genomic instability, including telomere instability and resulting replicative senescence and dysfunction in human chondrocytes. …”
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    Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function
  4. 2984
    “…PURPOSE: The development of osteoarthritis (OA) has been linked to mechanical factors. Studies suggest that periodic mechanical stress (PMS) may be a factor contributing to cartilage repair and the onset of OA. …”
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    Periodic Mechanical Stress Inhibits the Development of Osteoarthritis via Regulating ATF3-Akt Axis
  5. 2985
    “…RA patients exercised more frequently than OA patients (χ(2) = 3.9, P < 0.05). Nine RA patients and one OA patient had diabetes (χ(2) = 4.5, P < 0.05). …”
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    Cardiovascular risk in rheumatoid arthritis versus osteoarthritis: acute phase response related decreased insulin sensitivity and high-density lipoprotein cholesterol as well as clustering of metabolic syndrome features in rheumatoid arthritis
  6. 2986
    “…Ceiling effects were present in the mild OA group for the subscales Pain, Symptoms and ADL and for the subscale Sport/Recreation in the severe OA group. …”
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    The Dutch version of the knee injury and osteoarthritis outcome score: A validation study
  7. 2987
    “…To date, these studies have focused primarily on patients with OA under rheumatological care, which represent the minority of people living with OA. …”
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    Fatigue in osteoarthritis: a qualitative study
  8. 2988
    “…INTRODUCTION: Pomegranate has been revered throughout history for its medicinal properties. p38-MAPK is a major signal-transducing pathway in osteoarthritis (OA) and its activation by interleukin-1β (IL-1β) plays a critical role in the expression and production of several mediators of cartilage catabolism in OA. …”
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    Pomegranate extract inhibits the interleukin-1β-induced activation of MKK-3, p38α-MAPK and transcription factor RUNX-2 in human osteoarthritis chondrocytes
  9. 2989
    “…Three diisocyanates can cause occupational asthma (OA): toluene diisocyanate (TDI), 4,4 diphenylmethane diisocyanate (MDI), and 1,6-hexamethylene diisocyanate (HDI). …”
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    Biomarkers Predicting Isocyanate-Induced Asthma
  10. 2990
    “…BACKGROUND: Osteoarthritis (OA) is the most common joint disease, causing pain and functional impairments. …”
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    Cost-effectiveness of exercise therapy versus general practitioner care for osteoarthritis of the hip: design of a randomised clinical trial
  11. 2991
    “…BACKGROUND: Osteoarthritis (OA) is a prevalent progressive musculoskeletal disorder, leading to pain and disability. …”
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    Development of a brief multidisciplinary education programme for patients with osteoarthritis
  12. 2992
    “…Animal models of OA aid in the understanding of the pathogenesis of OA and testing suitable drugs for OA treatment. …”
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    Application of in vivo micro-computed tomography in the temporal characterisation of subchondral bone architecture in a rat model of low-dose monosodium iodoacetate-induced osteoarthritis
  13. 2993
    “…BACKGROUND: Recent studies have implied that osteoarthritis (OA) is a metabolic disease linked to deregulation of genes involved in lipid metabolism and cholesterol efflux. …”
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    Central Role of SREBP-2 in the Pathogenesis of Osteoarthritis
  14. 2994
    “…We were keen therefore to assess whether the effect that rs1676486 has on COL11A1 expression in LDH is also observed in OA and whether the rs2615977 association to OA also marked AEI. …”
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    Allelic expression analysis of the osteoarthritis susceptibility gene COL11A1 in human joint tissues
  15. 2995
    “…BACKGROUND: Knee osteoarthritis (kOA) risk is increased by obesity and physical activities (PA) which mechanically stress the joint. …”
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    Body mass index, occupational activity, and leisure-time physical activity: an exploration of risk factors and modifiers for knee osteoarthritis in the 1946 British birth cohort
  16. 2996
    “…BACKGROUND: Therapeutic gene transfer is of significant value to elaborate efficient, durable treatments against human osteoarthritis (OA), a slow, progressive, and irreversible disorder for which there is no cure to date. …”
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    rAAV-mediated overexpression of TGF-β stably restructures human osteoarthritic articular cartilage in situ
  17. 2997
    “…At each visit, subjects were defined as having symptomatic OA (SxOA) if ≥ one knee had pain and radiographic OA or if they had a TKR. …”
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    Comparing the functional impact of knee replacements in two cohorts
  18. 2998
    “…BACKGROUND: Knee osteoarthritis (OA) is a complex disease involving both biomechanical and metabolic factors that alter the tissue homeostasis of articular cartilage and subchondral bone. …”
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    An intron polymorphism of the fibronectin gene is associated with end-stage knee osteoarthritis in a Han Chinese population: two independent case-control studies
  19. 2999
    “…BACKGROUND: To enhance guideline-based non-surgical management of hip or knee osteoarthritis (OA), a multidisciplinary, stepped-care strategy has been implemented in primary care in a region of the Netherlands. …”
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    Patient reported barriers and facilitators to using a self-management booklet for hip and knee osteoarthritis in primary care: results of a qualitative interview study
  20. 3000
    “…BACKGROUND: Osteoarthritis (OA) is one of the most common joint diseases in elderly people, however, the underlying mechanism of OA pathogenesis is not completely clear. …”
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    Expression and pathological effects of periostin in human osteoarthritis cartilage
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