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2981“…The association between osteoarthritis (OA) and gastrointestinal disorders was found in observational studies. …”
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2982“…While morphologic and biochemical aspects of degenerative joint disease (osteoarthritis [OA]) have been elucidated by numerous studies, the molecular mechanisms underlying the progressive loss of articular cartilage during OA development remain largely unknown. …”
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2983por Yudoh, Kazuo, van Trieu, Nguyen, Nakamura, Hiroshi, Hongo-Masuko, Kayo, Kato, Tomohiro, Nishioka, Kusuki“…Oxidative stress leads to increased risk for osteoarthritis (OA) but the precise mechanism remains unclear. We undertook this study to clarify the impact of oxidative stress on the progression of OA from the viewpoint of oxygen free radical induced genomic instability, including telomere instability and resulting replicative senescence and dysfunction in human chondrocytes. …”
Publicado 2005
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2984“…PURPOSE: The development of osteoarthritis (OA) has been linked to mechanical factors. Studies suggest that periodic mechanical stress (PMS) may be a factor contributing to cartilage repair and the onset of OA. …”
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2985“…RA patients exercised more frequently than OA patients (χ(2) = 3.9, P < 0.05). Nine RA patients and one OA patient had diabetes (χ(2) = 4.5, P < 0.05). …”
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2986por de Groot, Ingrid B, Favejee, Marein M, Reijman, Max, Verhaar, Jan AN, Terwee, Caroline B“…Ceiling effects were present in the mild OA group for the subscales Pain, Symptoms and ADL and for the subscale Sport/Recreation in the severe OA group. …”
Publicado 2008
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2987por Power, J Denise, Badley, Elizabeth M, French, Melissa R, Wall, Angela J, Hawker, Gillian A“…To date, these studies have focused primarily on patients with OA under rheumatological care, which represent the minority of people living with OA. …”
Publicado 2008
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2988“…INTRODUCTION: Pomegranate has been revered throughout history for its medicinal properties. p38-MAPK is a major signal-transducing pathway in osteoarthritis (OA) and its activation by interleukin-1β (IL-1β) plays a critical role in the expression and production of several mediators of cartilage catabolism in OA. …”
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2989“…Three diisocyanates can cause occupational asthma (OA): toluene diisocyanate (TDI), 4,4 diphenylmethane diisocyanate (MDI), and 1,6-hexamethylene diisocyanate (HDI). …”
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2990por van Es, Pauline P, Luijsterburg, Pim AJ, Dekker, Joost, Koopmanschap, Marc A, Bohnen, Arthur M, Verhaar, Jan AN, Koes, Bart W, Bierma-Zeinstra, Sita MA“…BACKGROUND: Osteoarthritis (OA) is the most common joint disease, causing pain and functional impairments. …”
Publicado 2011
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2991por Moe, Rikke H, Haavardsholm, Espen A, Grotle, Margreth, Steen, Eldri, Kjeken, Ingvild, Hagen, Kåre Birger, Uhlig, Till“…BACKGROUND: Osteoarthritis (OA) is a prevalent progressive musculoskeletal disorder, leading to pain and disability. …”
Publicado 2011
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2992por Mohan, Geetha, Perilli, Egon, Kuliwaba, Julia S, Humphries, Julia M, Parkinson, Ian H, Fazzalari, Nicola L“…Animal models of OA aid in the understanding of the pathogenesis of OA and testing suitable drugs for OA treatment. …”
Publicado 2011
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2993por Kostopoulou, Fotini, Gkretsi, Vasiliki, Malizos, Konstantinos N., Iliopoulos, Dimitrios, Oikonomou, Pagona, Poultsides, Lazaros, Tsezou, Aspasia“…BACKGROUND: Recent studies have implied that osteoarthritis (OA) is a metabolic disease linked to deregulation of genes involved in lipid metabolism and cholesterol efflux. …”
Publicado 2012
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2994Allelic expression analysis of the osteoarthritis susceptibility gene COL11A1 in human joint tissues“…We were keen therefore to assess whether the effect that rs1676486 has on COL11A1 expression in LDH is also observed in OA and whether the rs2615977 association to OA also marked AEI. …”
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2995por Martin, Kathryn R, Kuh, Diana, Harris, Tamara B, Guralnik, Jack M, Coggon, David, Wills, Andrew K“…BACKGROUND: Knee osteoarthritis (kOA) risk is increased by obesity and physical activities (PA) which mechanically stress the joint. …”
Publicado 2013
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2996por Venkatesan, Jagadeesh K, Rey-Rico, Ana, Schmitt, Gertrud, Wezel, Anna, Madry, Henning, Cucchiarini, Magali“…BACKGROUND: Therapeutic gene transfer is of significant value to elaborate efficient, durable treatments against human osteoarthritis (OA), a slow, progressive, and irreversible disorder for which there is no cure to date. …”
Publicado 2013
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2997por Niu, Jingbo, Nevitt, Michael, McCulloch, Charles, Torner, James, Lewis, C Elizabeth, Katz, Jeffrey N, Felson, David T“…At each visit, subjects were defined as having symptomatic OA (SxOA) if ≥ one knee had pain and radiographic OA or if they had a TKR. …”
Publicado 2014
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2998por Yang, Hsin-Yi, Su, Sui-Lung, Peng, Yi-Jen, Wang, Chih-Chien, Lee, Herng-Sheng, Salter, Donald M, Lee, Chian-Her“…BACKGROUND: Knee osteoarthritis (OA) is a complex disease involving both biomechanical and metabolic factors that alter the tissue homeostasis of articular cartilage and subchondral bone. …”
Publicado 2014
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2999por Cuperus, Nienke, Smink, Agnes J, Bierma-Zeinstra, Sita MA, Dekker, Joost, Schers, Henk J, de Boer, Fijgje, van den Ende, Cornelia H, Vliet Vlieland, Thea PM“…BACKGROUND: To enhance guideline-based non-surgical management of hip or knee osteoarthritis (OA), a multidisciplinary, stepped-care strategy has been implemented in primary care in a region of the Netherlands. …”
Publicado 2013
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3000por Chijimatsu, Ryota, Kunugiza, Yasuo, Taniyama, Yoshiaki, Nakamura, Norimasa, Tomita, Tetsuya, Yoshikawa, Hideki“…BACKGROUND: Osteoarthritis (OA) is one of the most common joint diseases in elderly people, however, the underlying mechanism of OA pathogenesis is not completely clear. …”
Publicado 2015
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