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  1. 3021
    “…OBJECTIVE: To investigate whether Oleanolic acid (OA) could improve memory deficit in AD model and its possible mechanism. …”
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    Oleanolic Acid Ameliorates Aβ(25-35) Injection-induced Memory Deficit in Alzheimer’s Disease Model Rats by Maintaining Synaptic Plasticity
  2. 3022
    “…Prg4 has been used to prevent surgically induced osteoarthritis (OA) in mice. Surgically induced OA serves as a good model for post-traumatic OA but is not ideal for recapitulating age-related OA. …”
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    Prg4 prevents osteoarthritis induced by dominant-negative interference of TGF-ß signaling in mice
  3. 3023
    “…Increasing evidences show that aberrant subchondral bone remodeling plays an important role in the development of osteoarthritis (OA). However, how subchondral bone formation is activated and the mechanism by which increased subchondral bone turnover promotes cartilage degeneration during OA remains unclear. …”
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    Activation of mTORC1 in subchondral bone preosteoblasts promotes osteoarthritis by stimulating bone sclerosis and secretion of CXCL12
  4. 3024
    “…Clinically, osteoarthritis (OA) pain is significantly associated with synovial inflammation. …”
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    The polyadenylation inhibitor cordycepin reduces pain, inflammation and joint pathology in rodent models of osteoarthritis
  5. 3025
    “…Osteoarthritis (OA) is a joint disease resulting in high rates of disability and low quality of life. …”
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    Identification of the Biomarkers and Pathological Process of Osteoarthritis: Weighted Gene Co-expression Network Analysis
  6. 3026
    “…The purpose of the current study was to establish an in vitro model for osteoarthritis (OA) by co-culture of osteochondral and synovial membrane explants. …”
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    Co-culture of osteochondral explants and synovial membrane as in vitro model for osteoarthritis
  7. 3027
    “…Previous research showed that a simple target interception task reveals differences between younger adults (YA) and older adults (OA) on a large screen under laboratory conditions. …”
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    A Simple Target Interception Task as Test for Activities of Daily Life Performance in Older Adults
  8. 3028
    “…BACKGROUND: Osteoarthritis (OA) is the common chronic degenerative joint bone disease that is mainly featured by joint stiffness and cartilage degradation. …”
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    Icariin alleviates osteoarthritis by inhibiting NLRP3-mediated pyroptosis
  9. 3029
    “…However, its role on osteoarthritis (OA) has not been explored. Objective: This study investigates the effect of Dex on OA rat model induced by papain. …”
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    Dexmedetomidine inhibits the NF-κB pathway and NLRP3 inflammasome to attenuate papain-induced osteoarthritis in rats
  10. 3030
    “…BACKGROUND: The pathophysiology of osteoarthritis (OA) involves wear and tear, and a state of low-grade inflammation. …”
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    Fibroblast-like synovial cell production of extra domain A fibronectin associates with inflammation in osteoarthritis
  11. 3031
    “…OBJECTIVES: To determine (1) the prevalence of ankle osteoarthritis (OA) among former professional football and rugby players, (2) assess the association between ankle injuries or ankle surgeries with ankle OA, and (3) compare the mental and physical quality of life (QoL) between former professional football and rugby players with and without OA. …”
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    Ankle osteoarthritis and its association with severe ankle injuries, ankle surgeries and health-related quality of life in recently retired professional male football and rugby players: a cross-sectional observational study
  12. 3032
    “…BACKGROUND/OBJECTIVE: The microstructure of the subchondral trabecular bone, including the composition and distribution of plates and rods, has an important influence on the disease progression and mechanical properties of osteoarthritis (OA) and osteoporosis (OP). We aimed to determine whether differences in plates and rods influence the variations in the quantities and qualities of the subchondral trabecular bone between OA and OP. …”
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    Differences in subchondral trabecular bone microstructure and finite element analysis-based biomechanical properties between osteoporosis and osteoarthritis
  13. 3033
    “…OBJECTIVE: To identify risk factors for pain and functional deterioration in people with knee and hip osteoarthritis (OA) to form the basis of a future ‘stratification tool’ for OA development or progression. …”
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    Risk factors for pain and functional impairment in people with knee and hip osteoarthritis: a systematic review and meta-analysis
  14. 3034
    por Cheng, Ming, Wang, Yue
    Publicado 2020
    “…BACKGROUND: MiR-103a-3p is a small non-coding RNA and has been reported to be involved in osteogenic proliferation and differentiation, but the role of miR-103a-3p in human osteoarthritis (OA) remains unclear. OBJECTIVES: In this study, we aimed to explore its function and molecular target in chondrocytes during OA pathogenesis. …”
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    Downregulation of HMGB1 by miR-103a-3p Promotes Cell Proliferation, Alleviates Apoptosis and in Flammation in a Cell Model of Osteoarthritis
  15. 3035
    “…The prevalence of knee OA was 13.44%. Abortion is associated with knee OA (odds ratio [OR] = 1.271, 95% confidence interval [CI] = 1.007, 1.606), but age at menarche, parity, and menopausal status were not the factors. …”
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    Abortion is associated with knee osteoarthritis among older women in China: A STROBE-compliant article
  16. 3036
    “…PURPOSE: This study aimed to explore the potential role and mechanism of garlic-derived S-allylmercaptocysteine (SAMC), the major water-soluble fraction of garlic, in osteoarthritis (OA) both in vivo and in vitro. METHODS: The effect of SAMC in a surgical-induced OA model was examined by X-ray, staining, ELISA, and immunoblotting. …”
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    S-Allylmercaptocysteine Targets Nrf2 in Osteoarthritis Treatment Through NOX4/NF-κB Pathway
  17. 3037
    “…The dysregulated circular RNAs (circRNAs) are relevant to the development of osteoarthritis (OA). The circRNA serpin family E member 2 (circSERPINE2) is dysregulated in OA, while the role and mechanism of circSERPINE2 in OA are largely unknown. …”
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    CircSERPINE2 weakens IL-1β-caused apoptosis and extracellular matrix degradation of chondrocytes by regulating miR-495/TGFBR2 axis
  18. 3038
    “…Radix Angelicae biseratae is a widely used Chinese traditional herbal medicine for osteoarthritis (OA). Its therapeutic efficacy has been confirmed in clinical practice. …”
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    Anti-inflammatory activity of Radix Angelicae biseratae in the treatment of osteoarthritis determined by systematic pharmacology and in vitro experiments
  19. 3039
    “…BACKGROUND: Knee osteoarthritis (OA) is a major cause of disability in the elderly, however, there are few studies to estimate the global prevalence, incidence, and risk factors of knee OA. …”
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    Global, regional prevalence, incidence and risk factors of knee osteoarthritis in population-based studies
  20. 3040
    por Fan, Haiyan, Ding, Liangjia, Yang, Yun
    Publicado 2021
    “…Osteoarthritis (OA) is a common age-related joint disorder, for which no effective disease-modifying drugs are currently available. …”
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    lncRNA SNHG16 promotes the occurrence of osteoarthritis by sponging miR-373-3p
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