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3021por Wang, Kai, Sun, Weiming, Zhang, Linlin, Guo, Wei, Xu, Jiachun, Liu, Shuang, Zhou, Zhen, Zhang, Yulian“…OBJECTIVE: To investigate whether Oleanolic acid (OA) could improve memory deficit in AD model and its possible mechanism. …”
Publicado 2018
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3022“…Prg4 has been used to prevent surgically induced osteoarthritis (OA) in mice. Surgically induced OA serves as a good model for post-traumatic OA but is not ideal for recapitulating age-related OA. …”
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3023por Lin, Chuangxin, Liu, Liangliang, Zeng, Chun, Cui, Zhong-Kai, Chen, Yuhui, Lai, Pinling, Wang, Hong, Shao, Yan, Zhang, Haiyan, Zhang, Rongkai, Zhao, Chang, Fang, Hang, Cai, Daozhang, Bai, Xiaochun“…Increasing evidences show that aberrant subchondral bone remodeling plays an important role in the development of osteoarthritis (OA). However, how subchondral bone formation is activated and the mechanism by which increased subchondral bone turnover promotes cartilage degeneration during OA remains unclear. …”
Publicado 2019
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3024por Ashraf, Sadaf, Radhi, Masar, Gowler, Peter, Burston, James J., Gandhi, Raj D., Thorn, Graeme J., Piccinini, Anna M., Walsh, David A., Chapman, Victoria, de Moor, Cornelia H.“…Clinically, osteoarthritis (OA) pain is significantly associated with synovial inflammation. …”
Publicado 2019
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3025por Gu, Hui-Yun, Yang, Min, Guo, Jia, Zhang, Chao, Lin, Lu-Lu, Liu, Yang, Wei, Ren-Xiong“…Osteoarthritis (OA) is a joint disease resulting in high rates of disability and low quality of life. …”
Publicado 2019
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3026por Haltmayer, Eva, Ribitsch, Iris, Gabner, Simone, Rosser, Julie, Gueltekin, Sinan, Peham, Johannes, Giese, Ulrich, Dolezal, Marlies, Egerbacher, Monika, Jenner, Florien“…The purpose of the current study was to establish an in vitro model for osteoarthritis (OA) by co-culture of osteochondral and synovial membrane explants. …”
Publicado 2019
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3027por de Dieuleveult, Alix L., Perry, Sander I. B., Siemonsma, Petra C., Brouwer, Anne-Marie, van Erp, Jan B. F.“…Previous research showed that a simple target interception task reveals differences between younger adults (YA) and older adults (OA) on a large screen under laboratory conditions. …”
Publicado 2019
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3028“…BACKGROUND: Osteoarthritis (OA) is the common chronic degenerative joint bone disease that is mainly featured by joint stiffness and cartilage degradation. …”
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3029“…However, its role on osteoarthritis (OA) has not been explored. Objective: This study investigates the effect of Dex on OA rat model induced by papain. …”
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3030por Kragstrup, Tue W., Sohn, Dong H., Lepus, Christin M., Onuma, Kazuhiro, Wang, Qian, Robinson, William H., Sokolove, Jeremy“…BACKGROUND: The pathophysiology of osteoarthritis (OA) involves wear and tear, and a state of low-grade inflammation. …”
Publicado 2019
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3031por Paget, Liam D. A., Aoki, Haruhito, Kemp, Simon, Lambert, Mike, Readhead, Clint, Stokes, Keith A, Viljoen, Wayne, Reurink, Gustaaf, Tol, Johannes L, Kerkhoffs, Gino M M J, Gouttebarge, Vincent“…OBJECTIVES: To determine (1) the prevalence of ankle osteoarthritis (OA) among former professional football and rugby players, (2) assess the association between ankle injuries or ankle surgeries with ankle OA, and (3) compare the mental and physical quality of life (QoL) between former professional football and rugby players with and without OA. …”
Publicado 2020
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3032por He, Zihao, Chu, Linyang, Liu, Xuqiang, Han, Xuequan, Zhang, Kai, Yan, Mengning, Li, Xiaofeng, Yu, Zhifeng“…BACKGROUND/OBJECTIVE: The microstructure of the subchondral trabecular bone, including the composition and distribution of plates and rods, has an important influence on the disease progression and mechanical properties of osteoarthritis (OA) and osteoporosis (OP). We aimed to determine whether differences in plates and rods influence the variations in the quantities and qualities of the subchondral trabecular bone between OA and OP. …”
Publicado 2020
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3033“…OBJECTIVE: To identify risk factors for pain and functional deterioration in people with knee and hip osteoarthritis (OA) to form the basis of a future ‘stratification tool’ for OA development or progression. …”
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3034“…BACKGROUND: MiR-103a-3p is a small non-coding RNA and has been reported to be involved in osteogenic proliferation and differentiation, but the role of miR-103a-3p in human osteoarthritis (OA) remains unclear. OBJECTIVES: In this study, we aimed to explore its function and molecular target in chondrocytes during OA pathogenesis. …”
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3035por Meng, Yan-Ting, Wang, Yuan-Yuan, Zhou, Yan-Hui, Fu, Jing-Xia, Chen, Ming-Zhu, Xu, Chen, Qin, Si, Luo, Yang“…The prevalence of knee OA was 13.44%. Abortion is associated with knee OA (odds ratio [OR] = 1.271, 95% confidence interval [CI] = 1.007, 1.606), but age at menarche, parity, and menopausal status were not the factors. …”
Publicado 2020
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3036por Yang, Guang, Sun, Shui, Wang, Jian, Li, Wei, Wang, Xianquan, Yuan, Lin, Li, Siying“…PURPOSE: This study aimed to explore the potential role and mechanism of garlic-derived S-allylmercaptocysteine (SAMC), the major water-soluble fraction of garlic, in osteoarthritis (OA) both in vivo and in vitro. METHODS: The effect of SAMC in a surgical-induced OA model was examined by X-ray, staining, ELISA, and immunoblotting. …”
Publicado 2020
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3037“…The dysregulated circular RNAs (circRNAs) are relevant to the development of osteoarthritis (OA). The circRNA serpin family E member 2 (circSERPINE2) is dysregulated in OA, while the role and mechanism of circSERPINE2 in OA are largely unknown. …”
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3038“…Radix Angelicae biseratae is a widely used Chinese traditional herbal medicine for osteoarthritis (OA). Its therapeutic efficacy has been confirmed in clinical practice. …”
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3039“…BACKGROUND: Knee osteoarthritis (OA) is a major cause of disability in the elderly, however, there are few studies to estimate the global prevalence, incidence, and risk factors of knee OA. …”
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3040“…Osteoarthritis (OA) is a common age-related joint disorder, for which no effective disease-modifying drugs are currently available. …”
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