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  1. 3101
    “…BACKGROUND/OBJECTIVE: Osteoarthritis (OA) is a multifactorial joint disease associated with the deterioration of chondrocytes and inflammation. …”
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    Therapeutic effect of induced pluripotent stem cell -derived extracellular vesicles in an in vitro and in vivo osteoarthritis model
  2. 3102
    por Williams, Frances MK
    Publicado 2009
    “…The field of biomarkers is a growing one, particularly in osteoarthritis (OA). OA is the most common disabling condition in older persons and a major cause of morbidity. …”
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    Biomarkers: in combination they may do better
  3. 3103
    “…We noted a trend toward a decrease in ABCB1, ABCC1 and ABCG2 expression in HBL-100 cells treated with OA. The in silico and in vitro methods suggested that OA is neither a direct inhibitor nor a competitive substrate of P-gp in overexpressing P-gp cancer cells. …”
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    The Molecular Mechanisms of Oleanane Aldehyde-β-enone Cytotoxicity against Doxorubicin-Resistant Cancer Cells
  4. 3104
    “…AIMS: To assess the incidence of radiological lateral osteoarthritis (OA) at 15 years after medial unicompartmental knee arthroplasty (UKA) and assess the relationship of lateral OA with symptoms and patient characteristics. …”
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    Incidence and severity of radiological lateral osteoarthritis 15 years following medial unicompartmental knee arthroplasty
  5. 3105
    “…OBJECTIVES: Increasing evidence have demonstrated the N6-methyladenosine (m(6)A) plays critical roles in osteoarthritis (OA) progression, but the role of m(6)A in OA has not been completely illuminated. …”
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    FTO-mediated m6A demethylation of pri-miR-3591 alleviates osteoarthritis progression
  6. 3106
    “…BACKGROUND: Osteoarthritis (OA), a multifaceted condition, poses a significant challenge for the successful clinical development of therapeutics due to heterogeneity. …”
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    Obesity defined molecular endotypes in the synovium of patients with osteoarthritis provides a rationale for therapeutic targeting of fibroblast subsets
  7. 3107
    “…OBJECTIVES/GOALS: We developed a non-invasive test of ocular alignment (OA) as a measure of otolith asymmetry, which impacts vestibular function. …”
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    27 Measuring Ocular Misalignment by Age at Space Center Houston to Inform Spaceflight Analysis
  8. 3108
    “…OBJECTIVES: Erosive hand osteoarthritis (EHOA) is a severe subset of hand osteoarthritis (OA). It is unclear if EHOA is genetically different from other forms of OA. …”
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    Meta-analysis of erosive hand osteoarthritis identifies four common variants that associate with relatively large effect
  9. 3109
    “…PURPOSE: To compare radiographic worsening of OA in knees with RTs versus NRTs and to identify factors associated with radiographic worsening of OA in knees with RTs. …”
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    Association of Medial Meniscus Root Tears and Nonroot Tears With Worsening of Radiographic Knee Osteoarthritis
  10. 3110
    “…BACKGROUND: The prevention and treatment of osteoarthritis (OA) pose a major challenge in its research. The synovium is a critical tissue in the systematic treatment of OA. …”
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    Synovium is a sensitive tissue for mapping the negative effects of systemic iron overload in osteoarthritis: identification and validation of two potential targets
  11. 3111
    “…Exposure to high glucose (30 mM) for 18 or 48 hours decreased those parameters in normal but not in OA chondrocytes. GLUT-1 mRNA levels were unaffected by high glucose, either in normal or OA chondrocytes. …”
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    Impaired glucose transporter-1 degradation and increased glucose transport and oxidative stress in response to high glucose in chondrocytes from osteoarthritic versus normal human cartilage
  12. 3112
    “…Plasma miR-132 well differentiated HCs from patients with RA or OA, while synovial fluid miRNAs differentiated RA and OA. …”
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    Plasma and synovial fluid microRNAs as potential biomarkers of rheumatoid arthritis and osteoarthritis
  13. 3113
    “…BACKGROUND: Osteoarthritis (OA) is one of the most common causes of pain and disability in the adult population. …”
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    Quality of hip and knee osteoarthritis management in primary health care in a Norwegian county: a cross-sectional survey
  14. 3114
    “…INTRODUCTION: Cathepsin K (catK) expression is increased in cartilage, bone and synovium during osteoarthritis (OA). To study the role of catK expression and elevated cathepsin activity in the synovium on cartilage destruction in established OA, we overexpressed cystatin C (cysC), a natural cysteine protease inhibitor, in the synovium of rabbit OA joints. …”
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    Overexpression of cystatin C in synovium does not reduce synovitis or cartilage degradation in established osteoarthritis
  15. 3115
    “…BACKGROUND: Previous research indicates that people with osteoarthritis (OA) are not receiving the recommended and optimal treatment. …”
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    Implementing international osteoarthritis treatment guidelines in primary health care: study protocol for the SAMBA stepped wedge cluster randomized controlled trial
  16. 3116
    “…BACKGROUND: Hydrarthrosis, which is associated with knee pain and limited range of motion, decreases the quality of life (QOL) of patients with osteoarthritis (OA). The Kampo medicine boiogito is prescribed for the treatment of knee OA with hydrarthrosis; however, its precise mechanisms of action remain unknown. …”
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    Boiogito, a Kampo medicine, improves hydrarthrosis in a rat model of knee osteoarthritis
  17. 3117
    “…Lastly, the functional outcome of oAβ(1–42)-TREM2 interaction was tested by examining impacts on microglial migration in vitro and clustering around oAβ(1–42)-bearing brain areas in vivo. …”
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    Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2)
  18. 3118
    “…BACKGROUND: Osteoarthritis (OA) in the thumb carpometacarpal joint (CMCJ) is a prevalent disease which may lead to structural damage, severe pain and functional limitations. …”
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    Non-pharmacological treatment gap preceding surgical consultation in thumb carpometacarpal osteoarthritis - a cross-sectional study
  19. 3119
    por Marino, Katherine, Lee, Rachel, Lee, Paul
    Publicado 2019
    “…BACKGROUND: Knee osteoarthritis (OA) affects an estimated 1 in 5 individuals older than 45 years of age in the United Kingdom. …”
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    Effect of Germanium-Embedded Knee Sleeve on Osteoarthritis of the Knee
  20. 3120
    “…BACKGROUND: Platelet-rich plasma (PRP) provides a nonsurgical approach for treating osteoarthritis (OA). Exosomes that play vital roles in intercellular communication have been studied extensively. …”
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    Exosomes derived from platelet-rich plasma present a novel potential in alleviating knee osteoarthritis by promoting proliferation and inhibiting apoptosis of chondrocyte via Wnt/β-catenin signaling pathway
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