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3161“…Here, we explored the role of the mechanical responsive microRNA miR-365 in pathogenesis of osteoarthritis (OA). We found that miR-365 was up-regulated by cyclic loading and IL-1β stimulation in articular chondrocytes through a mechanism that involved the transcription factor NF-κB. miR-365 expressed significant higher level in rat anterior cruciate ligament (ACL) surgery induced OA cartilage as well as human OA cartilage from primary OA patients and traumatic OA Patients. …”
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3162por Lurati, Alfredomaria, Laria, Antonella, Gatti, Arianna, Brando, Bruno, Scarpellini, Magda“…OBJECTIVE: To determine distribution of T cells and activation degree of Th CD4+ cells in peripheral blood of patients with osteoarthritis (OA), rheumatoid arthritis (RA), and healthy donors. …”
Publicado 2015
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3163por Sesia, Sergio B., Berger, Eliane, Holland-Cunz, Stefan, Mayr, Johannes, Häcker, Frank-Martin“…A total of 555 children had undergone SPA and 420 had been treated by OA. Median operative time of SPA was longer than that of OA (60.8 min vs 57.4 min; P < 0.05). …”
Publicado 2015
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3164por Tran, Gui, Smith, Toby O, Grice, Adam, Kingsbury, Sarah R, McCrory, Paul, Conaghan, Philip G“…BACKGROUND: To assess the relationship between sport and osteoarthritis (OA), and specifically to determine whether previous participation, in terms of level (elite or non-elite), type of sport, intensity or previous injury, was associated with OA. …”
Publicado 2016
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3165“…Although OA was first discovered in mollusks (octopus), subsequent studies on OA, TA and related receptors have primarily been conducted in Ecdysozoa, especially in insects. …”
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3166por Rhee, Jinseol, Park, Seo-Hee, Kim, Seul-Ki, Kim, Jin-Hong, Ha, Chul-Won, Chun, Churl-Hong, Chun, Jang-Soo“…BATF expression in mouse joint tissues promoted OA cartilage destruction, and conversely, knockout of Batf in mice suppressed experimental OA. …”
Publicado 2017
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3167por Gates, L. S., Leyland, K. M., Sheard, S., Jackson, K., Kelly, P., Callahan, L. F., Pate, R., Roos, E. M., Ainsworth, B., Cooper, C., Foster, C., Newton, J. L., Batt, M. E., Arden, N. K.“…Physical activity (PA) is increasingly recognised as an important factor within studies of osteoarthritis (OA). However, subjective methods used to assess PA are highly variable and have not been developed for use within studies of OA, which creates difficulties when comparing and interpreting PA data in OA research. …”
Publicado 2017
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3168por Ratnayake, Madhushika, Tselepi, Maria, Bloxham, Robert, Plöger, Frank, Reynard, Louise N., Loughlin, John“…Osteoarthritis (OA) is a common joint disease characterised by the focal loss of the protective cartilage layer at the ends of the bones. …”
Publicado 2017
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3169“…The aim of the present study was to evaluate mutations of the G protein-coupled receptor 143 (GPR143) gene for ocular albinism type 1 (OA1) in Chinese patients. For the current study, 8 patients with OA1 were selected from the database of ocular genetic diseases. …”
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3170por Lin, Sheng-Hsiung, Wang, Ting-Chuan, Lai, Chun-Fu, Tsai, Ru-Yin, Yang, Chih-Ping, Wong, Chih-Shung“…The cumulative incidence rates of OA and total knee replacement (TKR) were analyzed using the Kaplan-Meier estimator. …”
Publicado 2017
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3171por Pearson, Mark J., Herndler-Brandstetter, Dietmar, Tariq, Mohammad A., Nicholson, Thomas A., Philp, Ashleigh M., Smith, Hannah L., Davis, Edward T., Jones, Simon W., Lord, Janet M.“…Increasing evidence suggests that inflammation plays a central role in driving joint pathology in certain patients with osteoarthritis (OA). Since many patients with OA are obese and increased adiposity is associated with chronic inflammation, we investigated whether obese patients with hip OA exhibited differential pro-inflammatory cytokine signalling and peripheral and local lymphocyte populations, compared to normal weight hip OA patients. …”
Publicado 2017
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3172“…Evidence from observational studies shows that hypertension may be a risk factor for knee osteoarthritis (OA). However, the relationship between hypertension and knee OA risk remains controversial. …”
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3173por Mathiessen, Alexander, Slatkowsky-Christensen, Barbara, Kvien, Tore K, Haugen, Ida K, Berner Hammer, Hilde“…BACKGROUND: Structural pathology may be present in joints without radiographic evidence of osteoarthritis (OA). Ultrasound is a sensitive tool for early detection of osteophytes. …”
Publicado 2017
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3174por Zhan, Dong, Thumtecho, Suthimon, Tanavalee, Aree, Yuktanandana, Pongsak, Anomasiri, Wilai, Honsawek, Sittisak“…AIM: To investigate the possible relationship of adiponectin (ADIPOQ) gene polymorphisms, plasma adiponectin, and the risk of knee osteoarthritis (OA). METHODS: A total of 398 subjects, 202 knee OA patients and 196 healthy individuals, were enrolled in the case-control study. …”
Publicado 2017
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3175por Kuttapitiya, Anasuya, Assi, Lena, Laing, Ken, Hing, Caroline, Mitchell, Philip, Whitley, Guy, Harrison, Abiola, Howe, Franklyn A, Ejindu, Vivian, Heron, Christine, Sofat, Nidhi“…METHODS: We recruited 98 participants, 72 with advanced OA requiring total knee replacement (TKR), 12 with mild OA and 14 non-OA controls. …”
Publicado 2017
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3176“…Osteoarthritis (OA) is a multifactorial joint disease, which includes joint degeneration, intermittent inflammation, and peripheral neuropathy. …”
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3177por Karmarkar, Taruja D., Maurer, Anne, Parks, Michael L., Mason, Thomas, Bejinez-Eastman, Ana, Harrington, Melvyn, Morgan, Randall, O’Connor, Mary I., Wood, James E., Gaskin, Darrell J.“…BACKGROUND: Disparities in the presentation of knee osteoarthritis (OA) and in the utilization of treatment across sex, racial, and ethnic groups in the United States are well documented. …”
Publicado 2017
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3178por Lanno, Stephen M., Gregory, Sara M., Shimshak, Serena J., Alverson, Maximilian K., Chiu, Kenneth, Feil, Arden L., Findley, Morgan G., Forman, Taylor E., Gordon, Julia T., Ho, Josephine, Krupp, Joanna L., Lam, Ivy, Lane, Josh, Linde, Samuel C., Morse, Ashley E., Rusk, Serena, Ryan, Robie, Saniee, Avva, Sheth, Ruchi B., Siranosian, Jennifer J., Sirichantaropart, Lalitpatr, Sternlieb, Sonya R., Zaccardi, Christina M., Coolon, Joseph D.“…Toxicity of Morinda fruit is primarily due to high levels of octanoic acid (OA). Using RNA interference (RNAi), prior work found that knockdown of Osiris family genes Osiris 6 (Osi6), Osi7, and Osi8 led to increased susceptibility to OA in adult D. melanogaster flies, likely representing genes underlying a Quantitative Trait Locus (QTL) for OA resistance in D. sechellia. …”
Publicado 2017
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3179“…The present study aimed to investigate the expression of receptor-interacting protein kinase 4 (RIPK4) and its effect on the apoptosis and proliferation of chondrocytes in osteoarthritis (OA). A total of 28 OA cartilage tissues and 20 normal cartilage tissues were collected to detect the expression of RIPK4 by using reverse transcription-quantitative polymerase chain reaction and western blot analysis. …”
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3180por Ji, Quanbo, Qi, Dengbin, Xu, Xiaojie, Xu, Yameng, Goodman, Stuart B., Kang, Lei, Song, Qi, Fan, Zhongyi, Maloney, William J., Wang, Yan“…Cryptotanshinone (CTS) has emerged as an anti-inflammatory agent in osteoarthritis (OA). However, the molecular mechanism underlying its potent therapeutic effect on OA remains largely unknown. …”
Publicado 2018
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