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  1. 3301
    “…However, little is known about how treatment with OA affect the brain in chronic pain patients. Gaining this knowledge is a necessary first step towards understanding OA associated analgesia and elucidating long-term risk of OA misuse. …”
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    Brain Structure and Function of Chronic Low Back Pain Patients on Long-Term Opioid Analgesic Treatment: A Preliminary Study
  2. 3302
    “…Osteoarthritis (OA) is a chronic health condition. MicroRNAs (miRs) are critical in chondrocyte apoptosis in OA. …”
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    microRNA-130b downregulation potentiates chondrogenic differentiation of bone marrow mesenchymal stem cells by targeting SOX9
  3. 3303
    “…Osteoarthritis (OA) is an age-related degenerative disease that causes cartilage dysfunction and inflammation. …”
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    Obtusifolin, an Anthraquinone Extracted from Senna obtusifolia (L.) H.S.Irwin & Barneby, Reduces Inflammation in a Mouse Osteoarthritis Model
  4. 3304
    “…Treating osteoarthritis (OA) remains a major clinical challenge. Despite recent advances in drug discovery and development, no disease-modifying drug for knee OA has emerged with any notable clinical success, in part, due to the lack of valid and responsive therapeutic targets and poor drug delivery within knee joints. …”
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    Phospholipase A(2) inhibitor–loaded micellar nanoparticles attenuate inflammation and mitigate osteoarthritis progression
  5. 3305
    “…Further, key genes for RA and OA were obtained by combined analysis with differentially expressed genes (DEGs) between RA and OA in GSE56409 dataset. …”
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    Marker Genes Change of Synovial Fibroblasts in Rheumatoid Arthritis Patients
  6. 3306
    “…BACKGROUND: Exercise is widely regarded to improve pain and function in patients with knee osteoarthritis (OA) through building supportive muscle mass, facilitating weight loss, and through the other beneficial effects associated with it. …”
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    Arthroscopy Association of Canada Position Statement on Exercise for Knee Osteoarthritis: A Systematic Review of Guidelines
  7. 3307
    “…A previous study showed that OA promotes retinal ganglion cell (RGC) survival after optic nerve (ON) crush injury. …”
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    Protective Effects of Oroxylin A on Retinal Ganglion Cells in Experimental Model of Anterior Ischemic Optic Neuropathy
  8. 3308
    “…Considering non-linear nature of cartilage loss in OA, a better understanding of inflammatory milieu and MMP status at different stages of OA is required to design early-stage therapies or personalized disease management. …”
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    Synovium-Synovial Fluid Axis in Osteoarthritis Pathology: A Key Regulator of the Cartilage Degradation Process
  9. 3309
    “…Over the past decades, numerous studies on the genetic markers of osteoarthritis (OA) have been conducted. MiRNA targets sites are a promising new area of research. …”
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    Association between miRNA Target Sites and Incidence of Primary Osteoarthritis in Women from Volga-Ural Region of Russia: A Case-Control Study
  10. 3310
    “…ADAMTS5 is involved in the pathogenesis of OA. As the major aggrecanase-degrading articular cartilage matrix, ADAMTS5, has been regarded as a potential target for OA treatment. …”
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    ADAMTS5 in Osteoarthritis: Biological Functions, Regulatory Network, and Potential Targeting Therapies
  11. 3311
    “…WHAT IS ALREADY KNOWN ABOUT THIS TOPIC? OA has been listed as the fastest increasing major public health problem and ranked second as a cause of disability by World Health Organization (WHO). …”
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    Epidemiological Characteristics of Osteoarthritis in Yichang City — Hubei Province, China, 2017–2018
  12. 3312
    “…Osteoarthritis (OA) is a chronic joint disease characterized by articular cartilage degeneration and secondary bone hyperplasia. …”
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    Monomeric C-reactive protein level is associated with osteoarthritis
  13. 3313
    “…Osteoarthritis (OA) causes persistent pain, joint dysfunction, and physical disability. …”
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    Chaenomeles Fructus (CF), the Fruit of Chaenomeles sinensis Alleviates IL-1β Induced Cartilage Degradation in Rat Articular Chondrocytes
  14. 3314
    “…A relationship between an acidic pH in the joints, osteoarthritis (OA), and pain has been previously demonstrated. …”
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    AcidoCEST-UTE MRI Reveals an Acidic Microenvironment in Knee Osteoarthritis
  15. 3315
    “…Studies have shown that oleanolic acid (OA) can effectively regulate neurotransmitter-related metabolic disorders caused by EH, but the mechanism is still unclear. …”
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    Targeted neurotransmitter metabolomics profiling of oleanolic acid in the treatment of spontaneously hypertensive rats
  16. 3316
    “…Introduction Osteoarthritis (OA) of the knee is a common complaint in the elderly population and results in considerable disability in advanced stages. …”
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    Improvement in Pain and Quality of Life After Ultrasound-Guided Saphenous Nerve Block in Patients With Knee Osteoarthritis
  17. 3317
    “…Bone pathologies such as osteoporosis (OTP) and osteoarthritis (OA) are rising in incidence with the worldwide rise in life expectancy. …”
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    Metabolomic Analysis of Severe Osteoarthritis in a Spanish Population of Women Compared to Healthy and Osteoporotic Subjects
  18. 3318
    “…The inflammatory environment of osteoarthritis (OA) inhibits the repair ability of CPCs. But the OA patients' CPCs showed an excellent regeneration ability with intermittent hydrostatic pressure (IHP). …”
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    Intermittent Hydrostatic Pressure Promotes Cartilage Repair in an Inflammatory Environment through Hippo-YAP Signaling In Vitro and In Vivo
  19. 3319
    “…Risk factors for osteoarthritis (OA) often exert effects over protracted time-courses. …”
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    Mendelian Randomization Studies of Lifestyle-Related Risk Factors for Osteoarthritis: A PRISMA Review and Meta-Analysis
  20. 3320
    “…OBJECTIVE: To conduct a network meta-analysis comparing all treatments for osteoarthritis (OA) pain in the Cochrane Library. DESIGN: The Cochrane Library and Epistemonikos were searched for randomized controlled trials (RCTs) about treatments for hip and knee OA. …”
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    Interventions for osteoarthritis pain: A systematic review with network meta-analysis of existing Cochrane reviews()
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