“…BACKGROUND: The pathogenesis of osteoarthritis (OA) is complex and there is no specific drug for treatment. …”
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“…Background: Osteoarthritis (OA) is a degenerative joint disease that occurs resulting from tear and progressive loss of articular cartilage. …”
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“…AIMS: To study the probability of seeking/undergoing aesthetic dental treatment (ADT) and compare self-perception of orofacial appearance (OA) based on sex, age, and monthly income; and to estimate the impact of OA on life satisfaction (LS) among Finnish and Brazilian adults, considering the indirect effect of receiving ADT and the moderating effects of those sociodemographic variables. …”
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“…All examined patients were divided into three groups: the Control group included conditionally healthy donors, group OA included patients with knee OA mainly stage II or III and the group of OA and COVID-19 included patients with OA who had COVID-19. …”
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“…The AOM400 cohort also required fewer visits to primary care, specialized care and emergency rooms than the OA cohort (p≤0.005). After 12 months, the AOM cohort was more persistent than the OA cohort (64.9% compared to 53.7%; p<0.001). …”
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“…The study population consisted of individuals diagnosed with schizophrenia who initiated their treatment with AOM400 (AOM cohort) or atypical OA (OA cohort) from 01/01/2017 to 31/12/2019. A 1:1 propensity score matching (PSM) procedure was conducted to match individuals of both cohorts. …”
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“…BACKGROUND: MMP-13 and IGFBP-5 are important factors involved in osteoarthritis (OA). We investigated whether two highly predicted microRNAs (miRNAs), miR-140 and miR-27a, regulate these two genes in human OA chondrocytes. …”
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“…OA synoviocytes were incubated with HMGB1 at 15 or 25 ng/ml in the absence or presence of IL-1β (10 ng/ml). …”
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“…OBJECTIVE: To assess if a coding variant in the gene encoding transient receptor potential cation channel, subfamily V, member 1 (TRPV1) is associated with genetic risk of painful knee osteoarthritis (OA). METHODS: The Ile585Val TRPV1 variant encoded by rs8065080 was genotyped in 3270 cases of symptomatic knee OA, 1098 cases of asymptomatic knee OA and 3852 controls from seven cohorts from the UK, the USA and Australia. …”
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“…The objective of this study was to investigate the anti-inflammatory/chondroprotective potential of a Herbal and amino acid mixture containing extract of the Uncaria tomentosa, Boswellia spp., Lepidium meyenii and L-Leucine on the IL-1β-induced production of nitric oxide (NO), glycosaminoglycan (GAG), matrix metalloproteinases (MMPs), aggrecan (ACAN) and type II collagen (COL2A1) in human OA chondrocytes and OA cartilage explants. METHODS: Primary OA chondrocytes or OA cartilage explants were pretreated with Herbal-Leucine mixture (HLM, 1-10 μg/ml) and then stimulated with IL-1β (5 ng/ml). …”
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“…We have identified 40 817 self-reported OA subjects and selected 1:1 matched non-OA respondents by age, sex and CCHS cycles. …”
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“…BACKGROUND: People with osteoarthritis (OA) frequently report that their joint pain is influenced by weather conditions. …”
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“…BACKGROUND: Osteoarthritis (OA) is the most common degenerative joint disorder, and a major cause of pain and disability among the elderly. …”
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“…BACKGROUND: Osteoarthritis (OA) is a common chronic disease of the joints. Genetic factors may play a role in its development, and polymorphisms in the estrogen receptor alpha gene (ERα) have been associated with OA. …”
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“…BACKGROUND: Osteoarthritis (OA) is a multi-factorial disease leading progressively to loss of articular cartilage and subsequently to loss of joint function. …”
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“…We sought to characterise this signal to assess whether the association of rs9350591 with OA is mediated by modulating gene expression. METHODS: Total RNA was extracted from hip or knee cartilage of 161 OA patients and from hip cartilage of 29 non-OA patients who had undergone hip replacements as a result of neck-of-femur (NOF) fractures. …”
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“…The WOMAC scores of participants with OA were higher than those without OA in males and females (male: 11.97±15.79 vs 8.23±12.84, p<0.001; female: 10.61±14.97 vs 7.59±3.31, p=0.032). …”
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“…INTRODUCTION: The primary complaint of patients with hand osteoarthritis (OA) is frequently the inelegant appearance of their hands. …”
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“…CRPM had prognostic value for progression of OA independent from the uCTX-II and COMP. CONCLUSIONS: Our study confirmed the associations between uCTX-II and COMP concentrations and OA progression. …”
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“…However, data were derived mostly from persons with knee OA, and there were few normal participants without knee OA in the data analyses. …”
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