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3441por Iwata, Nakao, Inagaki, Ataru, Sano, Hiromi, Niidome, Kazunari, Kojima, Yoshitsugu, Yamada, Sakiko“…To evaluate whether aripiprazole long-acting injection (aripiprazole once-monthly, AOM) can contribute to longer treatment persistence compared with daily orally administered aripiprazole (OA) in real-world clinical settings in Japan, treatment persistence in patients with schizophrenia was compared between patients treated with AOM and those with OA, using a claims database compiled by JMDC Inc., Tokyo, Japan. …”
Publicado 2020
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3442por Piotrowska, Katarzyna, Słuczanowska-Głabowska, Sylwia, Kurzawski, Mateusz, Dziedziejko, Violetta, Kopytko, Patrycja, Paczkowska, Edyta, Rogińska, Dorota, Safranow, Krzysztof, Machaliński, Bogusław, Pawlik, Andrzej“…In this study, we examined the expression of AIF-1 isoforms on the level of mRNA, and we compared the percentage of AIF-1-positive white blood cells (WBCs) in blood and AIF-1/CD68 cells in the synovial membranes in patients with rheumatoid arthritis (RA) and osteoarthritis (OA). We examined 15 patients with RA and 15 patients with OA who had previously undergone knee arthroplasty. …”
Publicado 2020
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3443“…OBJECTIVE: This study explored the association of patients’ demographics, health status, symptom severity, previous osteoarthritis (OA) care, and psychological status with the change in pain severity following a first-line intervention including education and exercise for OA provided nationwide in Swedish primary care. …”
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3444por Wu, Zongyi, Wang, Bingzhang, Tang, Jiahao, Bai, Bingli, Weng, Sheji, Xie, Zhongjie, Shen, Zijian, Yan, Deyi, Chen, Liang, Zhang, Jingdong, Yang, Lei“…BACKGROUND: The aim of the study was to evaluate the change of subchondral bone collagen and trabecular bone in the weight-bearing area of femoral head from patients with osteoarthritis (OA) or osteonecrosis of femoral head (ONFH), and discuss the effect of collagen degradation on OA and ONFH. …”
Publicado 2020
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3445por Wang, Lin, Zhang, Xiao-Fei, Zhang, Xue, Guo, Dong-Yan, Duan, Yu-Wei, Wang, Zhi-Chao, Pei, Li-Shan, Ru, Han, Cheng, Jiang-Xue, Shi, Ya-Jun, Zou, Jun-Bo“…BACKGROUND: Osteoarthritis (OA) is a common degenerative disease of bone and joint characterized by the damage of articular cartilage and hypertonia, which often occurs in the middle-aged and elderly. …”
Publicado 2020
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3446por Guo, Qiang, Chen, Ximiao, Chen, Jiaoxiang, Zheng, Gang, Xie, Chenglong, Wu, Hongqiang, Miao, Zhimin, Lin, Yan, Wang, Xiangyang, Gao, Weiyang, Zheng, Xiangtao, Pan, Zongyou, Zhou, Yifei, Wu, Yaosen, Zhang, Xiaolei“…Damaged deoxyribonucleic acid (DNA) is a primary pathologic factor for osteoarthritis (OA); however, the mechanism by which DNA damage drives OA is unclear. …”
Publicado 2021
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3447por Jiang, Liying, Zhou, Yiqin, Shen, Junjie, Chen, Yi, Ma, Ziyuan, Yu, Yuhui, Chu, Minjie, Qian, Qirong, Zhuang, Xun, Xia, Shengli“…OBJECTIVES: Given the roles played by lncRNA in human diseases and the high incidence of OA, this study investigated the pivotal pathways involved in the disease and identified potential biomarkers for OA diagnosis. …”
Publicado 2021
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3448“…Experimental OA in mice was induced by destabilization of the medial meniscus (DMM). …”
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3449por Bryk, Marta, Chwastek, Jakub, Mlost, Jakub, Kostrzewa, Magdalena, Starowicz, Katarzyna“…Osteoarthritis (OA) is a degenerative joint disease that primarily affects people over 65 years old. …”
Publicado 2021
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3450“…Synovitis of the knee synovium is proven to be a precursor of knee osteoarthritis (OA), leading to a radiologically advanced stage of the disease. …”
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3451“…AIMS: MicroRNA-183 (miR-183) is known to play important roles in osteoarthritis (OA) pain. The aims of this study were to explore the specific functions of miR-183 in OA pain and to investigate the underlying mechanisms. …”
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3452por Guillén, María Isabel, Tofiño-Vian, Miguel, Silvestre, Antonio, Castejón, Miguel Angel, Alcaraz, María José“…BACKGROUND: Osteoarthritis (OA) is a joint disease characterized by cartilage degradation, low-grade synovitis and subchondral bone alterations. …”
Publicado 2021
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3453por Fu, Shengxing, Duan, Tingjin, Hou, Meijin, Yang, Fengjiao, Chai, Yatai, Chen, Yongkang, Liu, Benke, Ma, Ye, Liu, Anmin, Wang, Xiangbin, Chen, Lidian“…This study aimed to compare individuals with knee OA and asymptomatic controls in postural balance and identify kinematic and lower extremity muscle activity characteristics in individuals with knee OA during the stand-to-sit task. …”
Publicado 2021
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3454por Huang, Yung-Cheng, Hsu, Shu-Meng, Shie, Feng-Shiun, Shiao, Young-Ji, Chao, Li-Jung, Chen, Hui-Wen, Yao, Heng-Hsiang, Chien, Meng An, Lin, Chung-Chih, Tsay, Huey-Jen“…Compared to NG, HG reduced the steady-state level of oAβ puncta internalized by microglia and astrocytes and decreased oAβ degradation kinetics. …”
Publicado 2022
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3455por Ko, Chih-Yuan, Xu, Jian-Hua, Chang, Yu-Wei, Lo, Yangming Martin, Wu, James Swi-Bea, Huang, Wen-Chung, Shen, Szu-Chuan“…Background and objectives: This study aimed to investigate the enhancing effect of vitamin-like alpha-lipoic acid (ALA) on phagocytosis of oligomeric beta-amyloid (oAβ)(1–42) in BV-2 mouse microglial cells. Methods: An in vitro model was established to investigate phagocytosis of oAβ(1–42) in BV-2 cells. …”
Publicado 2022
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3456por Takaoka, Ryota, Kuyama, Kotaro, Yatani, Hirofumi, Ishigaki, Shoichi, Kayashima, Hiroki, Koishi, Yukiko, Kato, Takafumi, Egusa, Hiroshi, Uchiyama, Yuka, Nakatani, Atsutoshi, Shimamoto, Hiroaki“…OBJECTIVES: The FTO gene has been reported as an obesity-associated gene and is also considered a risk gene for osteoarthritis (OA). However, its exact function is unclear, and there is conflicting evidence on the involvement of FTO polymorphisms in OA via obesity. …”
Publicado 2021
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3457“…Osteoarthritis (OA) is condition which poses a main concern to the aging population and its severity is expected to increase with the increasing life expectancy. …”
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3458por Ungsudechachai, Tachatra, Honsawek, Sittisak, Jittikoon, Jiraphun, Udomsinprasert, Wanvisa“…This study aimed to examine, a multifaceted chaperon-like protein exerting anti-inflammatory action, clusterin (CLU), mRNA and protein levels in the systemic and local joint environment of knee osteoarthritis (OA) patients and to determine whether CLU inhibited interleukin (IL)-1β-induced inflammation in knee OA fibroblast-like synoviocytes (FLSs) through modulating phosphatidylinositol-3-kinase (PI3K)/Akt signaling pathway. …”
Publicado 2022
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3459por Lu, Hanyu, Yang, Yixin, Ou, Shuanji, Qi, Yong, Li, Guitao, He, Hebei, Lu, Fanglian, Li, Wenjun, Sun, Hongtao“…BACKGROUND: Osteoarthritis (OA) is the most common joint disorder, and places a heavy burden on individuals and society. …”
Publicado 2022
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3460por Yin, Jianbin, Zeng, Hua, Fan, Kai, Xie, Haoyu, Shao, Yan, Lu, Yuheng, Zhu, Jinjian, Yao, Zihao, Liu, Liangliang, Zhang, Hongbo, Luo, Bingsheng, Wang, Xinjie, Zeng, Chun, Bai, Xiaochun, Zhang, Haiyan, Cai, Daozhang“…RNA sequencing of OA M1-polarized macrophages found highly expressed levels of pentraxin 3 (PTX3), suggesting a role for PTX3 in OA occurrence and development. …”
Publicado 2022
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