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  1. 3481
    “…Post-traumatic osteoarthritis in the temporomandibular joint (TMJ OA) is associated dysfunctional cell-matrix mediated signalling resulting from changes in the pericellular microenvironment after injury. …”
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    DISRUPTING MECHANICAL HOMEOSTASIS PROMOTES MATRIX METALLOPROTEINASE-13 MEDIATED PROCESSING OF NEURON GLIAL ANTIGEN 2 IN MANDIBULAR CONDYLAR CARTILAGE
  2. 3482
    “…METHODS: A total of 254 women with OA aged 50 years who underwent surgical treatment were enrolled in this study. …”
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    Body Composition and Bone Mineral Density in Postmenopausal Women with Advanced Knee Osteoarthritis Undergoing Surgical Treatment
  3. 3483
    “…Osteoarthritis (OA), a common joint disorder with articular cartilage degradation as the main pathological change, is the major source of pain and disability worldwide. …”
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    Enhancement of the therapeutic efficacy of mesenchymal stem cell-derived exosomes in osteoarthritis
  4. 3484
    “…BACKGROUND: The purpose of this study is to evaluate how hip or knee osteoarthritis (OA) and total joint arthroplasty impact the outcomes of patients undergoing lumbar decompression. …”
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    Effect of Lower Extremity Osteoarthritis on Outcomes of Lumbar Decompression
  5. 3485
    “…Aim: The “gut-joint” axis is suspected to be involved in the pathophysiology of osteoarthritis (OA). The present study aims at investigating the potential of lipoproteins (Lpps) secreted by Bifidobacterium longum to alleviate OA progression in the rat. …”
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    Free lipoproteins from Bifidobacterium longum alleviate osteoarthritis through modulation of the gut microbiome
  6. 3486
    “…We speculated that HIF-1α may have an important role in chondrocyte viability as a cell survival factor during the progression of osteoarthritis (OA). The expression of HIF-1α mRNA in human OA cartilage samples was analyzed by real-time PCR. …”
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    Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1α in articular chondrocytes: involvement of HIF-1α in the pathogenesis of osteoarthritis
  7. 3487
    “…The purpose of this study was to determine protein expression profiles of high-abundance synovial fluid (SF) proteins in health and in the prevalent joint disease osteoarthritis (OA). A cross-sectional study of 62 patients with early OA (n = 21), patients with late OA (n = 21), and control individuals (n = 20) was conducted. …”
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    High abundance synovial fluid proteome: distinct profiles in health and osteoarthritis
  8. 3488
    “…BACKGROUND: There have been reports both supporting and refuting an inverse relationship between hip fracture and hip osteoarthritis (OA). We explore this relationship using a case-control study design. …”
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    The association between hip fracture and hip osteoarthritis: A case-control study
  9. 3489
    “…CONCLUSIONS: This study found no significant association between the PPARG2 gene Pro12Ala missense mutation and knee OA. However, the presence of the Pro-Pro genotype of the PPARG2 gene mutation has a protective effect against development of OA.…”
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    Prevalence of the Pro12Ala missense mutation in the PPARG2 gene in Kuwaiti patients with primary knee osteoarthritis
  10. 3490
    “…METHODS: Community-living older adults with symptomatic knee and hip OA (n = 129) participated (68% with knee OA, 38% with hip OA). …”
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    Subgroups of older adults with osteoarthritis based upon differing comorbid symptom presentations and potential underlying pain mechanisms
  11. 3491
    “…Apoptosis of articular chondrocytes is associated with the pathogenesis of osteoarthritis (OA). Recently, we demonstrated that hypoxia-inducible factor (HIF)-2α, encoded by Epas1, causes OA cartilage destruction by regulating the expression of various matrix-degrading enzymes. …”
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    Hypoxia-inducible factor-2α regulates Fas-mediated chondrocyte apoptosis during osteoarthritic cartilage destruction
  12. 3492
    “…BACKGROUND: Okadaic acid (OA), a toxin produced by several dinoflagellate species is responsible for frequent food poisonings associated to shellfish consumption. …”
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    Identification of differentially expressed genes in SHSY5Y cells exposed to okadaic acid by suppression subtractive hybridization
  13. 3493
    “…INTRODUCTION: Osteoarthritis (OA) and osteoporosis (OP) are associated with loss of muscle bulk and power. …”
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    Differential features of muscle fiber atrophy in osteoporosis and osteoarthritis
  14. 3494
    “…METHODS: After the formation of a VCR-oleic acid ion-pair complex (VCR-OA), the VCR-OA-loaded submicron emulsion (VCR-OA-SME), prepared by classical high-pressure homogenization, was characterized and its in vitro anticancer effects were evaluated. …”
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    A novel submicron emulsion system loaded with vincristine–oleic acid ion-pair complex with improved anticancer effect: in vitro and in vivo studies
  15. 3495
    “…Although much research of injury induced OA has focused on cartilage, OA is a disease that affects the whole joint organ. …”
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    Synoviocytes protect cartilage from the effects of injury in vitro
  16. 3496
    “…OBJECTIVE: To study the effect of oleanolic acid (OA) on streptozotocin induced diabetic nephropathy in Sprague Dawley rats. …”
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    Oleanolic acid prevents progression of streptozotocin induced diabetic nephropathy and protects renal microstructures in Sprague Dawley rats
  17. 3497
    “…BACKGROUND: The purpose of this study was to examine the differences in gait profile between patients with knee osteoarthritis (OA) and healthy control and to create motion characteristics that will differentiate between them. …”
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    Analysis of knee flexion characteristics and how they alter with the onset of knee osteoarthritis: a case control study
  18. 3498
    “…Osteoarthritis (OA) is the most common form of joint disease in middle-aged individuals and the elderly. …”
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    Role of nuclear factor of activated T cells 1 in the pathogenesis of osteoarthritis
  19. 3499
    “…Chondrocyte apoptosis contributes to the pathogenesis of cartilage degeneration in osteoarthritis (OA). However, little is known about the effect and underlying mechanism of berberine on OA chondrocytes. …”
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    Berberine ameliorates cartilage degeneration in interleukin-1β-stimulated rat chondrocytes and in a rat model of osteoarthritis via Akt signalling
  20. 3500
    “…The objective of this study was to describe the extent of premature work loss (PWL) in OA consulters across a 6-year observation period, and associated factors. …”
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    Frequency and predictors of premature work loss in primary care consulters for osteoarthritis: prospective cohort study
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