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  1. 3561
    “…Drug therapy of osteoarthritis (OA) is limited by the short retention and lacking of stimulus-responsiveness after intra-articular (IA) injection. …”
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    pH-responsive and hyaluronic acid-functionalized metal–organic frameworks for therapy of osteoarthritis
  2. 3562
    “…Mesenchymal stem cells (MSCs) represent a great therapeutic promise in pre-clinical models of osteoarthritis (OA), but many questions remain as to their therapeutic mechanism of action: engraftment versus paracrine action. …”
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    THERAPEUTIC EFFICACY OF INTRA-ARTICULAR DELIVERY OF ENCAPSULATED HUMAN MESENCHYMAL STEM CELLS ON EARLY STAGE OSTEOARTHRITIS
  3. 3563
    “…Osteoarthritis (OA), which is characterized by proliferation of subchondral bone and the degeneration of articular cartilage, is the most prevalent human arthritis. …”
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    Activating Nrf2 signalling alleviates osteoarthritis development by inhibiting inflammasome activation
  4. 3564
    “…However, there was no significant difference in AHI reduction between the semi-fixed and fixed OA devices. Regarding the side effect of temporomandibular joint pain and patient preference, the semi-fixed OA device was superior to the fixed OA device on both measures. …”
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    Semi-fixed versus fixed oral appliance therapy for obstructive sleep apnea: A randomized crossover pilot study
  5. 3565
    “…BACKGROUND: Osteoarthritis (OA) is one of the most common degenerative diseases worldwide. …”
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    High expression of MAPK-14 promoting the death of chondrocytes is an important signal of osteoarthritis process
  6. 3566
    “…BACKGROUND: The use of conjoint analysis (CA) to elicit patients’ preferences for osteoarthritis (OA) treatment has the potential to contribute to tailoring treatments and enhancing patients’ compliance and adherence. …”
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    Systematic Review of Studies Using Conjoint Analysis Techniques to Investigate Patients’ Preferences Regarding Osteoarthritis Treatment
  7. 3567
    “…BACKGROUND: The posterior cruciate ligament (PCL) is one of the essential stabilizers of the knee joint and it was demonstrated that its degenerative change related to the knee osteoarthritis (OA). We aimed to evaluate signal of the PCL in OA patients in comparison with healthy young and elderly volunteers using the ultra-short echo timeenhanced (UTE)-T2∗ mapping, and to validate these findings with histology. …”
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    Evaluation of the degenerative pattern of PCL in osteoarthritis patients using UTE-T2 mapping
  8. 3568
    “…Osteoarthritis (OA) is a degenerative bone disease that involved micro and macro-environment of joints. …”
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    How miR-31-5p and miR-33a-5p Regulates SP1/CX43 Expression in Osteoarthritis Disease: Preliminary Insights
  9. 3569
    “…PURPOSE: To investigate the periarticular degenerative changes of the knee joint in association with osteoarthritis (OA). More tendinosis was expected to be found in the semitendinosus tendon in patients with knee OA than in patients without knee OA. …”
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    No significant histological or ultrastructural tendinosis changes in the hamstring tendon in patients with mild to moderate osteoarthritis of the knee?
  10. 3570
    “…The R20 and radiographs after the OA treatment were evaluated, and the changes from the baseline were analyzed. …”
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    Evaluation of Respiratory Resistance as a Predictor for Oral Appliance Treatment Response in Obstructive Sleep Apnea: A Pilot Study
  11. 3571
    “…The studied population consisted of 140 patients: 54 subjects with hip fracture (OP) without T2DM, 36 patients with hip fracture and T2DM (OP-T2DM), 28 patients with osteoarthritis (OA) without T2DM, and 22 patients with OA and T2DM (OA-T2DM). …”
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    Microstructural and Strength Changes in Trabecular Bone in Elderly Patients with Type 2 Diabetes Mellitus
  12. 3572
    “…CONCLUSION: A first‐line intervention for OA is associated with reduced willingness to undergo surgery, with a greater proportion among patients with knee OA than hip OA. …”
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    Willingness to Undergo Joint Surgery Following a First‐Line Intervention for Osteoarthritis: Data From the Better Management of People With Osteoarthritis Register
  13. 3573
    “…This study was designed to investigate the effect of PARP signalling in osteoarthritis (OA) cartilage inflammatory response in an OA rat model. …”
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    PARP-1 inhibition attenuates the inflammatory response in the cartilage of a rat model of osteoarthritis
  14. 3574
    “…Osteoarthritis (OA) is a major cause of cartilage pain and limited mobility in middle-aged and elderly individuals. …”
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    Chondro-Protective Effects of Shikimic Acid on Osteoarthritis via Restoring Impaired Autophagy and Suppressing the MAPK/NF-κB Signaling Pathway
  15. 3575
    “…Then they were histopathologically OARSI graded for the severity of OA. FRPE modeling revealed that non-fibrillar matrix modulus was higher in the healthy group compared to the early OA (p = 0.003) and advanced OA (p < 0.001) groups. …”
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    Elastic, Viscoelastic and Fibril-Reinforced Poroelastic Material Properties of Healthy and Osteoarthritic Human Tibial Cartilage
  16. 3576
    “…PSP restoration significantly opposed OA-induced DNA replication and cell proliferation arrest, underscoring the importance of this pathway for the anti-cancer activity of OA. …”
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    Oleanolic acid blocks the purine salvage pathway for cancer therapy by inactivating SOD1 and stimulating lysosomal proteolysis
  17. 3577
    “…Overexpression of silent information regulator 2 ortholog 1 (SIRT1) is associated with beneficial roles in aging-related diseases; however, the effects of SIRT1 overexpression on osteoarthritis (OA) progression have not yet been studied. The aim of this study was to investigate OA progression in SIRT1-KI mice using a mouse OA model. …”
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    Knee Osteoarthritis Progression Is Delayed in Silent Information Regulator 2 Ortholog 1 Knock-in Mice
  18. 3578
    “…BACKGROUND: Osteoarthritis (OA) has been identified as a common musculoskeletal condition. …”
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    Clinical therapeutic effects of combined diacerein and glucosamine in the treatment of osteoarthritis: A protocol for systematic review and meta-analysis
  19. 3579
    “…Fatty acid overload, either of the saturated palmitic acid (PA) or the unsaturated oleic acid (OA), causes triglyceride accumulation into specialized organelles termed lipid droplets (LD). …”
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    Differential Effects of Oleic and Palmitic Acids on Lipid Droplet-Mitochondria Interaction in the Hepatic Cell Line HepG2
  20. 3580
    “…However, with increasing understanding of OA pathology, several potential therapeutic targets have been identified, enabling the development of disease-modifying OA drugs (DMOADs). …”
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    Disease-modifying therapeutic strategies in osteoarthritis: current status and future directions
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