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3561por Xiong, Feng, Qin, Zainen, Chen, Haimin, Lan, Qiumei, Wang, Zetao, Lan, Nihan, Yang, Yuan, Zheng, Li, Zhao, Jinmin, Kai, Dan“…Drug therapy of osteoarthritis (OA) is limited by the short retention and lacking of stimulus-responsiveness after intra-articular (IA) injection. …”
Publicado 2020
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3562por McKinney, J.M., Doan, T.N., Wang, L., Deppen, J.N., Reece, D.S., Pucha, K.A., Ginn, S.C., Levit, R.D., Willett, N.J.“…Mesenchymal stem cells (MSCs) represent a great therapeutic promise in pre-clinical models of osteoarthritis (OA), but many questions remain as to their therapeutic mechanism of action: engraftment versus paracrine action. …”
Publicado 2019
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3563por Yan, Zijian, Qi, Weihui, Zhan, Jingdi, Lin, Zeng, Lin, Jian, Xue, Xinghe, Pan, Xiaoyun, Zhou, Yulong“…Osteoarthritis (OA), which is characterized by proliferation of subchondral bone and the degeneration of articular cartilage, is the most prevalent human arthritis. …”
Publicado 2020
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3564por Yanamoto, Souichi, Harata, Saori, Miyoshi, Taro, Nakamura, Norio, Sakamoto, Yuki, Murata, Maho, Soutome, Sakiko, Umeda, Masahiro“…However, there was no significant difference in AHI reduction between the semi-fixed and fixed OA devices. Regarding the side effect of temporomandibular joint pain and patient preference, the semi-fixed OA device was superior to the fixed OA device on both measures. …”
Publicado 2021
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3565por Deng, Zhiqin, Hu, Xiaotian, Alahdal, Murad, Liu, Jianquan, Zhao, Zhe, Chen, Xiaoqiang, Xie, Junxiong, Duan, Li, Wang, Daping, Li, Wencui“…BACKGROUND: Osteoarthritis (OA) is one of the most common degenerative diseases worldwide. …”
Publicado 2021
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3566“…BACKGROUND: The use of conjoint analysis (CA) to elicit patients’ preferences for osteoarthritis (OA) treatment has the potential to contribute to tailoring treatments and enhancing patients’ compliance and adherence. …”
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3567por Hayashi, Seiju, Nakasa, Tomoyuki, Matsuoka, Yoshiko, Akiyama, Yuji, Ishikawa, Masakazu, Nakamae, Atsuo, Awai, Kazuo, Adachi, Nobuo“…BACKGROUND: The posterior cruciate ligament (PCL) is one of the essential stabilizers of the knee joint and it was demonstrated that its degenerative change related to the knee osteoarthritis (OA). We aimed to evaluate signal of the PCL in OA patients in comparison with healthy young and elderly volunteers using the ultra-short echo timeenhanced (UTE)-T2∗ mapping, and to validate these findings with histology. …”
Publicado 2021
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3568por Costa, Viviana, De Fine, Marcello, Carina, Valeria, Conigliaro, Alice, Raimondi, Lavinia, De Luca, Angela, Bellavia, Daniele, Salamanna, Francesca, Alessandro, Riccardo, Pignatti, Giovanni, Fini, Milena, Giavaresi, Gianluca“…Osteoarthritis (OA) is a degenerative bone disease that involved micro and macro-environment of joints. …”
Publicado 2021
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3569por Ibrahim, Mustafa, Meknas, Khaled, Steigen, Sonja E., Olsen, Randi, Sernert, Ninni, Ejerhed, Lars, Kartus, Jüri-Toomas“…PURPOSE: To investigate the periarticular degenerative changes of the knee joint in association with osteoarthritis (OA). More tendinosis was expected to be found in the semitendinosus tendon in patients with knee OA than in patients without knee OA. …”
Publicado 2020
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3570por Ishiyama, Hiroyuki, Hideshima, Masayuki, Inukai, Shusuke, Tamaoka, Meiyo, Nishiyama, Akira, Miyazaki, Yasunari“…The R20 and radiographs after the OA treatment were evaluated, and the changes from the baseline were analyzed. …”
Publicado 2021
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3571por Giner, Mercè, Miranda, Cristina, Vázquez-Gámez, María Angeles, Altea-Manzano, Patricia, Miranda, María-José, Casado-Díaz, Antonio, Pérez-Cano, Ramón, Montoya-García, María-José“…The studied population consisted of 140 patients: 54 subjects with hip fracture (OP) without T2DM, 36 patients with hip fracture and T2DM (OP-T2DM), 28 patients with osteoarthritis (OA) without T2DM, and 22 patients with OA and T2DM (OA-T2DM). …”
Publicado 2021
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3572por Dell’Isola, Andrea, Jönsson, Thèrèse, Rolfson, Ola, Cronström, Anna, Englund, Martin, Dahlberg, Leif“…CONCLUSION: A first‐line intervention for OA is associated with reduced willingness to undergo surgery, with a greater proportion among patients with knee OA than hip OA. …”
Publicado 2021
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3573“…This study was designed to investigate the effect of PARP signalling in osteoarthritis (OA) cartilage inflammatory response in an OA rat model. …”
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3574por You, Hongbo, Zhang, Rui, Wang, Lingying, Pan, Qiyong, Mao, Zekai, Huang, Xiaojian“…Osteoarthritis (OA) is a major cause of cartilage pain and limited mobility in middle-aged and elderly individuals. …”
Publicado 2021
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3575por Ebrahimi, Mohammadhossein, Ojanen, Simo, Mohammadi, Ali, Finnilä, Mikko A., Joukainen, Antti, Kröger, Heikki, Saarakkala, Simo, Korhonen, Rami K., Tanska, Petri“…Then they were histopathologically OARSI graded for the severity of OA. FRPE modeling revealed that non-fibrillar matrix modulus was higher in the healthy group compared to the early OA (p = 0.003) and advanced OA (p < 0.001) groups. …”
Publicado 2019
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3576por Liu, Dan, Jin, Xing, Yu, Guanzhen, Wang, Mingsong, Liu, Lei, Zhang, Wenjuan, Wu, Jia, Wang, Fengying, Yang, Jing, Luo, Qin, Cai, Lili, Yang, Xi, Ke, Xisong, Qu, Yi, Xu, Zhenye, Jia, Lijun, Chen, Wen-Lian“…PSP restoration significantly opposed OA-induced DNA replication and cell proliferation arrest, underscoring the importance of this pathway for the anti-cancer activity of OA. …”
Publicado 2021
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3577por Yamamoto, Tetsuya, Miyaji, Nobuaki, Kataoka, Kiminari, Nishida, Kyohei, Nagai, Kanto, Kanzaki, Noriyuki, Hoshino, Yuichi, Kuroda, Ryosuke, Matsushita, Takehiko“…Overexpression of silent information regulator 2 ortholog 1 (SIRT1) is associated with beneficial roles in aging-related diseases; however, the effects of SIRT1 overexpression on osteoarthritis (OA) progression have not yet been studied. The aim of this study was to investigate OA progression in SIRT1-KI mice using a mouse OA model. …”
Publicado 2021
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3578“…BACKGROUND: Osteoarthritis (OA) has been identified as a common musculoskeletal condition. …”
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3579por Eynaudi, Andrea, Díaz-Castro, Francisco, Bórquez, Juan Carlos, Bravo-Sagua, Roberto, Parra, Valentina, Troncoso, Rodrigo“…Fatty acid overload, either of the saturated palmitic acid (PA) or the unsaturated oleic acid (OA), causes triglyceride accumulation into specialized organelles termed lipid droplets (LD). …”
Publicado 2021
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3580por Cho, Yongsik, Jeong, Sumin, Kim, Hyeonkyeong, Kang, Donghyun, Lee, Jeeyeon, Kang, Seung-Baik, Kim, Jin-Hong“…However, with increasing understanding of OA pathology, several potential therapeutic targets have been identified, enabling the development of disease-modifying OA drugs (DMOADs). …”
Publicado 2021
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