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  1. 3621
    “…Osteoarthritis (OA) is a low-level inflammatory disease in which synovial macrophage M1 polarization exacerbates the progression of synovitis and OA. …”
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    Blocking TRPV4 Ameliorates Osteoarthritis by Inhibiting M1 Macrophage Polarization via the ROS/NLRP3 Signaling Pathway
  2. 3622
    “…OBJECTIVES: An acute bout of exercise typically leads to short term exercise induced hypoalgesia (EIH), but this response is more variable in many chronic pain populations, including knee osteoarthritis (OA) and fibromyalgia (FM). There is evidence of autonomic nervous system (ANS) dysfunction in some chronic pain populations that may contribute to impaired EIH, but this has not been investigated in people with knee OA. …”
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    The autonomic and nociceptive response to acute exercise is impaired in people with knee osteoarthritis
  3. 3623
    “…An OA-limited condition facilitated the formation of [PbBr(4)](2−) and Cs(4)PbBr(6) NCs. …”
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    Manipulating the formation of cesium lead bromide nanocrystals via oleic acid
  4. 3624
    “…We evaluated the performance of the proposed MOBChOA-DCNN in comparison with nine competitive methods. …”
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    A Novel Multi-Objective Binary Chimp Optimization Algorithm for Optimal Feature Selection: Application of Deep-Learning-Based Approaches for SAR Image Classification
  5. 3625
    “…Osteoarthritis (OA) is hallmarked as a silent progressive rheumatic disease of the whole joint. …”
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    β Boswellic Acid Blocks Articular Innate Immune Responses: An In Silico and In Vitro Approach to Traditional Medicine
  6. 3626
    “…Osteoarthritis (OA) is a chronic disease common in the elderly population and imposes significant health and economic burden. …”
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    RNA-Seq Reveals the mRNAs, miRNAs, and lncRNAs Expression Profile of Knee Joint Synovial Tissue in Osteoarthritis Patients
  7. 3627
    “…BACKGROUND: Osteoarthritis (OA) is a chronic degenerative joint disease characterized by loss of joint function, which seriously reduces the quality of life of the elderly and imposes a heavy socioeconomic burden worldwide. …”
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    Monotropein attenuates apoptosis and pyroptosis in chondrocytes and alleviates osteoarthritis progression in mice
  8. 3628
    “…OBJECTIVE: We aimed to screen novel biomarkers for osteoarthritis (OA) using bioinformatic methods and explore its regulatory mechanism in OA development. …”
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    ITGB1 alleviates osteoarthritis by inhibiting cartilage inflammation and apoptosis via activating cAMP pathway
  9. 3629
    “…BACKGROUND: Physical activity improves pain and function among individuals with knee osteoarthritis (OA), but most people with this condition are inactive. …”
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    Physical therapy vs. internet-based exercise training (PATH-IN) for patients with knee osteoarthritis: study protocol of a randomized controlled trial
  10. 3630
    “…We studied whether sBGN or sDCN were present in synovial fluid (SF) of osteoarthritis (OA) or rheumatoid arthritis (RA) patients and studied sBGN or sDCN potential role in the degradation of OA cartilage. …”
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    Soluble biglycan: a potential mediator of cartilage degradation in osteoarthritis
  11. 3631
    “…BACKGROUND: Osteoarthritis (OA) is a complex disease, which affects multiple tissues, namely the subchondral bone, articular cartilage and synovial membrane. …”
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    Beneficial effect of resveratrol on phenotypic features and activity of osteoarthritic osteoblasts
  12. 3632
    “…Specific diagnostic biomarkers are lacking; hence, treatment options for OA are limited. Synovial inflammation is very common in OA joints and has been associated with both OA’s symptoms and pathogenesis. …”
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    CX3CL1 promotes MMP-3 production via the CX3CR1, c-Raf, MEK, ERK, and NF-κB signaling pathway in osteoarthritis synovial fibroblasts
  13. 3633
    “…BACKGROUND: Patients with knee osteoarthritis (OA) report knee pain, limitation in physical activities and low quality of life. …”
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    Efficacy of pre-operative quadriceps strength training on knee-extensor strength before and shortly following total knee arthroplasty: protocol for a randomized, dose-response trial (The QUADX-1 trial)
  14. 3634
    “…BACKGROUND: Orotic acid (OA) has been intensively utilized to induce fatty liver in rats. …”
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    Orotic acid-treated hepatocellular carcinoma cells resist steatosis by modification of fatty acid metabolism
  15. 3635
    “…ASI appears to lead to increased rates of OA, although risk factors for developing OA in cohorts treated nonoperatively and operatively are not well-defined. …”
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    Incidence of and Risk Factors for Glenohumeral Osteoarthritis After Anterior Shoulder Instability: A US Population–Based Study With Average 15-Year Follow-up
  16. 3636
    “…BACKGROUND: Osteoarthritis (OA) and rheumatoid arthritis (RA) were two major joint diseases with similar clinical phenotypes. …”
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    Identification and validation of hub genes of synovial tissue for patients with osteoarthritis and rheumatoid arthritis
  17. 3637
    “…PURPOSE: To systematically review the outcomes, failure rate, incidence, and predictors of osteoarthritis (OA) for different ACLR techniques at a minimum 20-year follow-up. …”
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    Clinical Outcomes and Osteoarthritis at Very Long-term Follow-up After ACL Reconstruction: A Systematic Review and Meta-analysis
  18. 3638
    por Que, Wenzhong, Liu, Huili, Yang, Qinqin
    Publicado 2022
    “…BACKGROUND: Osteoarthritis (OA) is a chronic degenerative joint disease. Extracellular matrix (ECM) degradation is essential for OA progression. …”
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    CircPRKCH modulates extracellular matrix formation and metabolism by regulating the miR-145/HGF axis in osteoarthritis
  19. 3639
    “…There were significant differences in age, disease duration, uric acid (UA), and total cholesterol (TC) between pSS-OA and pSS-nOA patients (P < 0.050). Logistic regression analysis showed that age (OR = 1.965; P = 0.009) and joint pain (OR = 3.382; P < 0.001) were dangerous factors associated with OA. …”
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    Osteoarthritis or arthritis? Toward understanding of primary Sjögren’s syndrome patients with arthralgia
  20. 3640
    “…The counts and cargo of extracellular vesicles (EVs), membrane-bound particles released by synovial joint cells and transporting bioactive lipids, can also be modified by OA. The detailed FA signatures of SF and its EVs have remained unexplored in the horse — a well-recognized veterinary model for OA research. …”
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    Equine osteoarthritis modifies fatty acid signatures in synovial fluid and its extracellular vesicles
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