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  1. 1641
    “…Despite extensive studies on the multifaceted roles of morroniside, the main active constituent of iridoid glycoside from Corni Fructus, the effect of morroniside on osteoarthritis (OA) chondrocytes remains poorly understood. Here, we investigated the influence of morroniside on cultured human OA chondrocytes and a rat experimental model of OA. …”
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    Protein kinase B and extracellular signal-regulated kinase contribute to the chondroprotective effect of morroniside on osteoarthritis chondrocytes
  2. 1642
    “…Accumulating evidence suggests that autophagy is closely related to the pathogenesis of osteoarthritis (OA). The aim of this study was to determine the changes in autophagy during the progression of OA and to elucidate the specific role of autophagy in OA. …”
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    Role of autophagy in the progression of osteoarthritis: The autophagy inhibitor, 3-methyladenine, aggravates the severity of experimental osteoarthritis
  3. 1643
    “…INTRODUCTION: In light of inconsistencies in the literature, this study aimed to investigate the relationship between obesity (current and historic) and osteoarthritis (OA) of the knee or hip. MATERIALS AND METHODS: We examined 99 people (knee OA, hip OA and controls), age > 50 years, in a case–control study. …”
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    Maximum lifetime body mass index is the appropriate predictor of knee and hip osteoarthritis
  4. 1644
    “…INTRODUCTION: Knee osteoarthritis (OA) can affect the hip and ankle joints, as these three joints operate as a kinetic/kinematic chain while walking. …”
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    Effects of Knee Osteoarthritis on Hip and Ankle Gait Mechanics
  5. 1645
    “…Background: Hand osteoarthritis (OA) is one of the most common joint diseases, but studies on biomarkers are rare. …”
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    Biomarkers of Hand Osteoarthritis Are Detectable after Mechanical Exercise
  6. 1646
    “…INTRODUCTION: Open access (OA) publishing rates have risen dramatically in the biomedical sciences in the past decade. …”
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    Publishing habits and perceptions of open access publishing and public access amongst clinical and research fellows
  7. 1647
    “…Osteoarthritis (OA) is the most common joint disease characterized by destruction of articular cartilage. …”
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    Clusterin exerts a cytoprotective and antioxidant effect in human osteoarthritic cartilage
  8. 1648
    “…Women are at a significantly higher risk of developing osteoarthritis (OA) compared to males. The pathogenesis of osteoarthritis (OA) in women is poorly understood. …”
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    Sex-Specific Differences in Extracellular Vesicle Protein Cargo in Synovial Fluid of Patients with Osteoarthritis
  9. 1649
    “…The purpose of this biomechanical simulation study was to examine JCL of TC gait, the most common used TC from and its causal interactions with muscle activations in knee OA. DESIGN: Six knee OA and five healthy participants were recruited. …”
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    Biomechanical joint loading mechanism of Tai Chi gait in individuals with knee osteoarthritis: A pilot simulation study
  10. 1650
    “…BACKGROUND: Osteoarthritis (OA) remains one of the most common osteopathy for centuries, which can be attributed to multiple risk factors including mechanical and biochemical ones. …”
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    Epigenetic modifications of tumor necrosis factor-alpha in joint cartilage tissue from osteoarthritis patients - CONSORT
  11. 1651
    “…Osteoarthritis (OA) associated pain (OA-pain) is a significant global problem. …”
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    Investigating the Role of Artemin and Its Cognate Receptor, GFRα3, in Osteoarthritis Pain
  12. 1652
    “…Semaphorin 3A (Sema3A), known to be a chemo-repellent for sensory nerve fibers, has recently been implicated in cartilage OA pathophysiology. We demonstrated that the expression of SEMA3A and its receptor neuropilin-1 (NRP1) are synchronously upregulated in chondrocytes isolated from knee cartilage of OA patients compared to non-OA control chondrocytes. …”
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    Semaphorin 3A-Neuropilin-1 Signaling Modulates MMP13 Expression in Human Osteoarthritic Chondrocytes
  13. 1653
    “…PLTX (270 μg/kg alone or 90 μg/kg associated with OA) also decreased the liver/body weight ratio, reducing hepatocyte glycogen (270 μg/kg, alone or combined with OA). …”
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    Acute Toxicity by Oral Co-Exposure to Palytoxin and Okadaic Acid in Mice
  14. 1654
    por Lambova, Sevdalina Nikolova
    Publicado 2023
    “…Obesity and the associated conditions (hyperglycemia, dyslipidemia, and hypertension) have been found to be risk factors for the development of knee OA, which has led to the emerging concept of the existence of a distinct phenotype, i.e., metabolic knee OA. …”
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    Pleiotropic Effects of Metformin in Osteoarthritis
  15. 1655
    “…RESULTS: Overall 2017 knee OA prevalence was 4% (615,514 knee OA/15.4M adults). …”
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    Real-World Health Care Resource Utilization and Costs Among US Patients with Knee Osteoarthritis Compared with Controls
  16. 1656
    “…Nitroalkene derivatives of nitro-oleic acid (OA-NO(2)) are endogenous lipid products with novel signaling properties, particularly the activation of PPARs. …”
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    Effects of Endogenous PPAR Agonist Nitro-Oleic Acid on Metabolic Syndrome in Obese Zucker Rats
  17. 1657
    por Haugen, Ida K, Bøyesen, Pernille
    Publicado 2011
    “…Hand osteoarthritis (OA) is very frequent in middle-aged and older women and men in the general population. …”
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    Imaging modalities in hand osteoarthritis - status and perspectives of conventional radiography, magnetic resonance imaging, and ultrasonography
  18. 1658
    “…Here we show using temporal control of neural function in Drosophila that only short-term appetitive memory is reinforced by OA. Moreover, OA-dependent memory formation requires signaling through DA neurons. …”
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    Layered reward signaling through octopamine and dopamine in Drosophila
  19. 1659
    “…However, it is still unknown if OA affects the migration and invasion of glioma cells. …”
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    Oleanolic Acid Suppresses Migration and Invasion of Malignant Glioma Cells by Inactivating MAPK/ERK Signaling Pathway
  20. 1660
    “…Inflammation plays a crucial role in the development and progression of osteoarthritis (OA). Interleukin-15 (IL-15) is a well-known proinflammatory cytokine. …”
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    Serum Interleukin-15 Levels Are Associated with Severity of Pain in Patients with Knee Osteoarthritis
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