“…Osteoarthritis (OA) is a major cause of disability in the adult population. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Osteoarthritis (OA) is a progressive joint disease characterized by a continuous degradation of the cartilage extracellular matrix (ECM). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Osteoarthritis (OA) is a degenerative and chronic joint disease characterized by clinical symptoms and distortion of joint tissues. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Osteoarthritis (OA) is a degenerative joint disease and an important cause of incapacitation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Evidences show that exosomes are involved in the pathogenesis of OA. In view of the important roles of exosomes in OA, this paper systematically reviewed the roles of exosomes in the pathogenesis of OA, including the roles of exosomes in OA diagnosis, the regulatory mechanisms of exosomes in the pathogenesis, and the intervention roles of exosomes in the treatment of OA. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…OA drugs at present are mainly palliative and do not halt or reverse disease progression. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Osteoarthritis (OA) is the most prevalent joint disease and a leading cause of disability in older adults. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This paper introduces a new bio-inspired metaheuristic algorithm called Walrus Optimization Algorithm (WaOA), which mimics walrus behaviors in nature. The fundamental inspirations employed in WaOA design are the process of feeding, migrating, escaping, and fighting predators. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This study aims to determine the relationship between elemental distribution and osteoarthritis (OA) progression based on disease severity. Using modified Mankin scores, we collected tibia plates from 9 knee OA patients who underwent knee replacement surgery and graded them as intact cartilage (non-OA) or degraded cartilage (OA). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…High BMI related burden of knee and hip osteoarthritis (OA) is on a significant rise worldwide. OA not only causes joint pain and stiffness, but it also leads to disability. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…There has been a growing interest in the role of the subchondral bone and its resident osteoclasts in the progression of osteoarthritis (OA). A recent genome-wide association study (GWAS) identified 100 independent association signals for OA traits. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…OBJECTIVES: Our aims were to replicate some previously reported associations of single nucleotide polymorphisms (SNPs) in five genes (A2BP1, COG5, GDF5, HFE, ESR1) with hand osteoarthritis (OA), and to examine whether genes (BCAP29, DIO2, DUS4L, DVWA, HLA, PTGS2, PARD3B, TGFB1 and TRIB1) associated with OA at other joint sites were associated with hand OA among Finnish women. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: Osteoarthritis (OA) is the most common joint disorder in the world and represents the leading cause of pain and disability in the elderly population. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…OBJECTIVES: (i) To provide baseline knowledge of gene expression in macroscopically normal articular cartilage, (ii) to test the hypothesis that age, body-mass-index (BMI), and sex are associated with cartilage RNA transcriptome, and (iii) to predict individuals at potential risk for developing “pre-osteoarthritis” (OA) based on screening of genetic risk-alleles associated with OA and gene transcripts differentially expressed between normal and OA cartilage. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Only a few studies have examined the association between OA and SRH in the general population, but to date none have used a clinical definition of OA. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: In Japan, the majority of hip osteoarthritis (OA) was caused by acetabular dysplasia, and about 90 % of patients were female. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In Phase 1, outcome assessments aimed to differentiate normal (n = 5; i.e. exempt of any radiographic and clinical sign of OA) from OA (n = 15) cats. In Phase 2, OA cats were treated twice daily with a placebo (PG: cornstarch 15 mg) or tramadol (TG: 3 mg/kg) orally for 19 days, with a 3-month washout period between treatments. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: Isolated lateral PF joint OA was more common than isolated medial PF joint OA, particularly at higher severity thresholds. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…It is a multifactorial disorder with a significant genetic component. The heritability of OA has been estimated to be 60% for hip OA and 39% for knee OA. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Oleanolic acid (OA), a biologically active pentacyclic triterpenoid compound, has been implicated in a number of clinical benefits including antioxidant, and anti-inflammatory properties. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso