“…Morphologically, phage DH1 showed a typical Myoviridae structure consisting of an isometric head (50 nm in diameter) and a visible tail. …”
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“…Particularly, compound 1 showed the best activity with ORAC values (U/mol) of 7.90 ± 0.52. …”
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“…A plausible biosynthetic pathway of 1 was also postulated. Compound 1 showed remarkable inhibitory activity against phosphodiesterase-4 (PDE4D2), with an IC(50) value of 40 nM, which is 20-fold higher than that of the positive control (rolipram). …”
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“…The isolated and synthetic compounds were applied in an anti-tumor bioassay, in which ginsenoside ORh(1) showed moderate effects on Murine H22 Hepatoma Cells.…”
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“…The structures of these compounds were determined to be α-pyrone-containing polyene analogues through analyses of HRFABMS, UV and NMR data, and were named Gombapyrones E (1) and F (2). Gombapyrone E (1) showed antibacterial activity against Micrococcus luteus, Enterococcus hirae, Staphylococcus aureus and MRSA.…”
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“…Biological screening showed that all the tested compounds, except 1, show excellent antifungal activity against C. albicans, while most of the compounds have also shown significant antibacterial activity against S. aureus, S. epidermidis, E. faecalis and P. aeruginosa.…”
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“…The stereochemistry of 1 was determined by ECD calculations. 1 showed about half of the extracellular radical scavenging effect (IC(50) = 161.4 μM) compared with resveratrol (IC(50) = 80.5 μM), while on biomembranes it exhibited the same range of protection effects against free radicals generated from AAPH (IC(50) = 78.6 μM and 87.9 μM).…”
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“…The question arises as to which interpretation is preferable. I show that the epistemic argument contradicts Evidentialism and suggest that the relative plausibility of Evidentialism provides grounds to prefer the pragmatic interpretation. …”
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“…Their structures and absolute configurations were determined by detailed NMR, MS spectroscopic data, Mo(2)(OAc)(4)-induced electronic circular dichroism (ECD), and circular dichroism (CD) spectroscopy. Compound 1 showed antibacterial activity against Staphylococcus aureus with an MIC value of 6.25 μg/mL. …”
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“…Feeding experiments of (13)C-labeled precursors clarified that ʟ-methionine-derived methylation takes place at the carbon which is derived from the carbonyl carbon of acetate. Compound 1 showed weak growth inhibition against Saccharomyces cerevisiae.…”
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“…After redirecting the discussion from truth to validity, I show that these rules are valid insofar as they fulfill Goodman’s criteria for inductive rules and Newton’s own methodological program of experimental philosophy; provided that cross-checks are used prior to applications of rule 4 and immediately after applications of rule 2 the following activities are pursued: (1) research addressing observations that systematically deviate from theoretical idealizations and (2) applications of theory that safeguard ongoing research from proceeding down a garden path.…”
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“…Now, there is evidence that this condition can be violated in biologically relevant cases (e.g., for vesicles) and that in such situations the partial-slip boundary condition is more suitable. I show (i) how the latter condition can be employed in the context of DLS and NTA and (ii) that the use of the former condition may result in underestimation of the nanoparticle radius by about 10 nm compared with the nominal one.…”
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“…In this article of EBioMedicine, Santosh Renuse and colleagues(1) show the relevance of combining immunoaffinity capture with targeted mass spectrometry measurement to detect SARS-CoV-2 nucleocapsid proteins in nasopharyngeal swab samples. …”
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“…After identifying different ways in which the senses of hypersensitive workers might be protected within these spaces, I show that many of such accommodations can be made at reasonable cost, before arguing that doing so ought to be a legal requirement.…”
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“…I find that the responses of the exchange rate EUR/USD to monetary policy shocks vary over time. In particular, I show that the QE policy does not generate the expected effect on the exchange rate during the COVID-19 pandemic period. …”
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“…The compound 1,2,4-Trimethyl-3-nitrobicyclo [3.3.1]nonan-9-one shows binding features with the cancer target protein RAD51 similar to the FDA approved drug of 5-Flurouracil for further consideration in the context of pancreatic cancer drug discovery.…”
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“…I discuss several background topics and the general status of the project after compressing the model and developing a data generator. I show how we quantify the model’s predictive performance and share data from the most recently trained model. …”
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“…RESULTS: Rs10419226 (CRTC1) showed a significantly increased EAC risk for the minor allele (OR = 1.17, P = 0.001), and rs11789015 (BARX1) showed a significantly decreased risk for the minor allele (OR = 0.85, P = 0.004) in the logistic regression analysis. …”
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“…The baseline cholesterol efflux capacity correlated positively with apolipoprotein (apo)A1 and C3, whereas apoA1 and apoC1 showed inverse associations with VCAM-1 expression. …”
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“…CONCLUSION: Compared to Fibrin, MAR-1 showed similar hemostatic properties, no adverse effects, and is biocompatible. …”
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