“…I implement the model out to 2028 and demonstrate that the enhanced secondary prevention that began in 1982 becomes increasingly cost-effective over the period 2013–2028. On the other hand, I show that reductions in mortality achieved by significantly enhancing secondary prevention beyond 2013 levels are comparable with those achieved by only modest improvements in late-stage disease survival. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSIONS: Ten-month-old infants with NF1 show a range of developmental difficulties that were particularly striking in motor and communication domains. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…However, the cellular respiration rate and carbon demand rate (both: mol C cell(−1) day(−1)) show statistically significant relations with cellular carbon content (mol C cell(−1)) in chemostats, turbidostats, and the literature data.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Five studies found earlier onset in preterm infants, 1 found later onset, and 1 showed both earlier and later menarche, depending on birth weight. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Both components, VpStyA2B and VpStyA1, showed monooxygenase activity on styrene of 0.14 U mg(−1) and 0.46 U mg(−1), as well as on benzyl methyl sulfide of 1.62 U mg(−1) and 3.11 U mg(−1), respectively. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The deduced features of Cs1 show a unique structure containing TRs and a signal peptide and the TR region is immunodominant in Cs1. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Peptides K(0)-W(6)-Hy-a1, Ocellatin 4-analogue, and citrus-amp1 showed bactericidal activity against X.citri and S. meliloti and bacteriostatic effect on A. tumefaciens. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…P1 showed less toxicity in THP-1 cell line than all other polymyxins checked. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This result indicates that the probe AIE-1 shows ACQ and probe AIE-2 shows AIE behaviors in THF-H(2)O solvent mixtures. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The German trial tested a different group-housing system constituted of four does and their kits to evaluate the same behavioral aspect. Experiment 1 showed that the time spent in seclusion or in group was almost the same (49.61% vs. 50.39%, respectively) whereas, experiment 2 showed that female does with kits preferred to stay alone (71.90%) rather than in a group, probably due to a hierarchical response stimulation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The liver histopathology of broiler chickens fed diets with AFB(1) showed diffused microvacuolar fatty degeneration. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Finally, (7) I show that the configurational entropy of a landscape is highly related to the dimensionality of the landscape, the number of cover classes, the evenness of landscape composition across classes, and landscape heterogeneity. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…[Image: see text] The marine natural product latonduine A (1) shows F508del-cystic fibrosis transmembrane regulator (CFTR) corrector activity in cell-based assays. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The deletion mutant of 5β-Δ(4)-kstd1 had a prolonged lag-phase with cholate as sole carbon source and, in accordance with the function of 5β-Δ(4)-KSTD1, showed delayed 3-ketocholate transformation. Purified 5β-Δ(4)-KSTD1 was specific for 5β-steroids in contrast to 5α-steroids and converted steroids with a variety of hydroxy groups regardless of the presence of a side chain. 5β-Δ(4)-KSTD1 showed a relatively low K(m) for 3-ketocholate, a very high specific activity and pronounced substrate inhibition. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSION: All the specimens when immersed in SS showed greater discoloration than compared to the specimens immersed in DW. Group I showed greater resistance to color change compared to other groups.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Analysis of diffusion-weighted MRI data of participants with NF1 showed significantly lower apparent fiber density within the ascending auditory brainstem pathways. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Further, miRNA transcriptome sequencing of SF-MSCs that treated with IDO1 showed significant downregulation of miR-122-5p which perfectly targets Wnt1. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The recognition face of nucleoside 1 for base-pair formation mimics that of 2′-de­oxy­thymidine. Nucleoside 1 shows two pK (a) values: 1.8 for pro­ton­ation and 11.2 for deprotonation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Regarding the latter 3 patients, 1 showed hypertension and tachycardia during anesthesia induction, 1 showed tachycardia during surgery and the other showed stability during surgery. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We selected compound 1 (where R is H and P is P(C(6)H(5))(3)), for further studies as it was the one showing the best biological effect. In a competitive assay with biotin, we showed that cell uptake via SMVT receptors seems to be the main transport route into the cells for this compound, validating the strategy of including biotin in the design of the compound. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso