“…Clear differences in RFS were noted based on cytokine level clustering both at baseline and at week 6: Patients whose PBMCs secreted more cytokines in response to NY-ESO-1 showed a trend towards better RFS. CONCLUSIONS: PBMCs of patients treated with ipi secreted significantly more cytokines, chemokines and growth factors in response to NY-ESO-1 than to gp-100 or MART-1. …”
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“…RESULTS: After correction for multiple testing, fasting concentrations of lysophosphatidylcholine-acyl (LysoPC-acyl) C16:1, LysoPC-acyl C16:0 and phosphatidylcholine-diacyl C32:1 showed strong positive correlations with BAT volume (β= 116 (85–148) mL, R(2) = 0.81, p = 4.6 × 10(−7) (;) β = 79 (93–119) mL, R(2) = 0.57, p = 5.9 × 10(−4) and β= 91 (40–141) mL, R(2) = 0.52, p = 1.0 × 10(−3), respectively) as well as with BAT activity (β= 0.20 (0.11–0.29) g/mL, R(2) = 0.59, p = 1.9 × 10(−4); β = 0.15 (0.06–0.23) g/mL, R(2) = 0.47, p = 2.0 × 10(−3) and β= 0.13 (0.01–0.25) g/mL, R(2) = 0.28, p = 0.04, respectively). …”
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“…RESULTS: The three R. ruber KstD enzymes have different substrate profiles. KstD1 shows preference for 9OHAD and testosterone, followed by progesterone, deoxy corticosterone AD and, finally, 4-BNC, corticosterone and 19OHAD. …”
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“…The degree of methyl esterification of pectin and the structures of the arabinan side chains of RG-I show some variation in the collenchyma CWs from the different segments. …”
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“…When non-responders to creatine loading were excluded (n = 6), responders (n = 8; total creatine content increasing from 70 to 106 mmol/kg(−1)) showed similar findings, with no signs of preservation of muscle mass or strength during immobilization. …”
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“…Three of the NILs, namely Pusa Basmati 1121-GN4.1, Samba Mahsuri-GN4.1 and Swarna-GN4.1, showed a significant yield superiority to their recipient parents. …”
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“…We also tested preference for presentation of access to information as FAQ or LIST by adding a CHOICE condition (a self-selected choice of FAQs or a list of information topics). RESULTS: Study 1 showed considerable consistency in information priorities among all 6 cohorts with 2 main concerns: treatment of CRC and risk factors. …”
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“…The validity of the CSS scale was assessed using Receiver Operating Characteristic (ROC) curves to determine the best clinical cut-off point for the CSS scale that maximizes sensitivity and specificity of the scale against the SCIP diagnosis of schizophrenia (the reference standard). RESULTS: Table (1) shows stable kappa values and standard error of 15 CSS items. …”
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“…Mice lacking the collagen‐binding integrin α(11)β(1) show a complex dermal phenotype with regard to the interstitial physiology apparent in the control of P (IF). …”
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“…Functionality analysis (study 1) showed that they offered an eclectic mix of features, including many not based on cognitive behavioral therapy practice. …”
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“…Dissolution tests, run to completion on LE1, showed that approximately 99% of loaded CA and 88% of RA had been released. …”
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“…Among these constructed strains, all of gene products exhibited annotated enzyme activities in the recombinant strain cells, and HJΔphaZ (phaA3), HJΔphaZ (phaB2), and HJΔphaZ (phaC1) showed about 1.1-, 1.1-, and 1.2-fold higher volumetric PHB production than that of the parent HJΔphaZ (pLP-1.2) strain. …”
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“…We fitted the model using LASSO (least absolute shrinkage and selection operator) regression, and reported the performance using C-statistic (scale 0–1, values > 0.5 show discrimination) and calibration slope (scale 0–1, values near 1 show accuracy) with 95% confidence intervals (CIs). …”
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“…MRI suggested a pituitary microadenoma; IPSS ACTH(I) showed a significant pituitary ACTH gradient. Pituitary surgery found a possible microadenoma (ACTH-negative). 3 months post-op, ACTH(I) was 57; heterophile Abs were negative. …”
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“…Post-hoc secondary analysis for RELY 2 versus RELY 1 showed a significant change in SEM(alternative.work) (− 5.2 percentage points WC(alternative.work) [95%CI − 9.7 to − 0.6]), and in the proportions on the differences ≤ 25 percentage points WC(alternative.work) between two experts (p = 0.008). …”
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“…Among those eight polymorphisms, rs2984613 in PMF1 showed significant association with LA in the cohort of 220 LA subjects, and such significant association remained in both general genetic model (OR: 0.262, 95% CI: 0.091–0.752, p (adj) = 0.030) and recessive model (OR: 0.323, 95% CI: 0.119–0.881, p (adj) = 0.038) when controlling for clinical variables. …”
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“…Penile tissues were processed for histological studies and western blot. Group I showed lower intracavernous pressure (ICP)/mean arterial pressure (MAP), lower area under the curve (AUC)/MAP, decreased immunohistochemical staining for alpha-smooth muscle (SM) actin, higher apoptotic index, lower SM/collagen ratio, increased phospho-LIMK2-positive fibroblasts, decreased protein kinase B/endothelial nitric oxide synthase (Akt/eNOS) phosphorylation, increased LIMK2/cofilin phosphorylation, and increased protein expression of fibronectin, compared to Group S. …”
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“…Correlating Cmin and Ctrough (Ctr) for group 1 and group 2 were 12 mg/L and 13.5 mg/L vs. 6.4 mg/L and 7.3 mg/L, respectively (P < 0.001). Figure 1 shows the pharmacokinetic parameters for each group. …”
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“…LF-Syn (0.32 – 2.70 × 10(4) cells mL(−1) ), HF-Syn (1.11 – 3.20 × 10(4) cells mL(−1)) and Speuk (0.99 – 4.81 × 10(2) cells mL(−1)) showed an inverse pattern to Prochlorococcus, while Lpeuk (0.16 – 7.05 × 10(4) cells mL(−1)) peaked in fall. …”
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“…Thirty-four (35.8%) patients were classified in the ‘progression stage’ based on CT imaging; these patients typically showed lesions in multiple lung segments and lobes (21/34，61.8%), and an uneven increase in ground-glass opacity density accompanied by consolidation and grid-like or cord-like shadows(30.5%). Two patients (2.1%) showed a severe presentation on CT. These showed diffuse bilateral lung lesions, mixed ground-glass opacities and consolidation with cord-like interstitial thickening and air bronchograms, entire lung involvement with a “white lung” presentation, and mild pleural effusion. …”
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