“…As compared to normal tissue, both WNT-10A and WNT-10B genes exhibited lower expression while WNT-6 and WNT-1 showed increased expression in breast cancer tissues. …”
Enlace del recurso
Enlace del recurso

“…Using the 1000 Genomes Project single-nucleotide polymorphism data provided by Genetic Analysis Workshop 17, I show that through biologically informative prior distributions, some power can be gained over noninformative prior distributions.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The microemulsion F-8 (contained 10% of isopropyl myristate as oil phase, 8% of aqueous phase, and 82% of surfactant phase containing Tween 80 and isopropyl alcohol, 3 : 1) showed the highest permeation flux of 0.284 ± 0.003 μg/cm(2)/hour. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…One stand showed a significant excess (F (IS) = −0.044) of heterozygosity, and one showed a deficit (F (IS) = 0.044). Our results demonstrate the importance of taking into account the biological and genetic characteristics of species in forest management, especially when determining a new seed stand. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We demonstrated the existence of a crosstalk between PTEN SUMOylation and ubiquitination, with PTEN-SUMO1 showing a reduced capacity to form covalent interactions with monoubiquitin and accumulation of PTEN-SUMO2 conjugates after inhibition of the proteasome. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The models are valid in pharmacology, enzymology, transportology as well as several other fields of biology involving allosteric concentration effects. RESULTS: I show here that Hall’s model for interactions between an orthoster, an alloster, and a receptive unit is the best choice of model both for simulation and analysis of allosteric concentration-responses at equilibrium or steady-state. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Furthermore, expression of MAP kinase phosphatase-1 (Mkp-1) shows diurnal changes in liver. These results indicate that Ras/ERK signaling is strictly regulated by the circadian clock in liver, and suggest that the circadian oscillation of the activities of Ras, MEK, and ERK may regulate diurnal variation of liver function and/or homeostasis.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A total of 1,452 serum samples were assayed by inhibition of GFP expression in comparison with those examined by conventional 100% inhibition of CPE. 1,367 (94.1%) showed similar neutralizing antibody titers when examined by both methods. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Specifically, Tregs in mice with a null mutation of the PARP-1 gene (PARP-1(–/–)) showed significantly stronger suppressive activity than did wild-type Tregs in culture. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The transcription of p21/WAF1 and transforming growth factor (TGF)-β1 showed similar changes in the fresh and embedded liver cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…It is shown, for the first time, that both within Japan and globally, ratios RN:(137)Cs in air were relatively constant for primarily particle associated radionuclides ((134,136)Cs; (132)Te) but that (131)I shows much lower local (<80 km) isotope ratios in soils relative to (137)Cs. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In particular, the new compound lobophorin H (1) showed similar antibacterial activities against B. subtilis CMCC63501 to ampicillin.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Histological and microcomputed tomography (µCT) analyses of the calvaria defect sites treated with CEMP1 showed that after 16 weeks, hrCEMP1 is able to induce 97% regeneration of the defect. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…TriTag-1 and TriTag-2 use alternative splicing to generate differentially localized GFP isoforms, localizing it to the chloroplasts, peroxisomes and cytosol. TriTag-1 shows a bias for targeting the chloroplast envelope while TriTag-2 preferentially targets the peroxisomes. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Here an obvious critique is that these models consider too few components, compared to what might be relevant for any particular cell function. I show here that mining approaches and dynamical systems theory are two ends of a spectrum of methodologies to choose from. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Uniparental disomy (UPD) analysis for chromosome 1 showed the presence of maternal UPD. Markers in the 1q21.3–q22 region flanking the LMNA locus were isodisomic, while markers in the short arm and distal 1q region were heterodisomic. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Results conclude that Gracilins preserve neurons against oxidative damage, and that in particular, tetrahydroaplysulphurin-1 shows a complete neuroprotective activity. Oxidative stress is linked to mitochondrial dysfunction and consequently to neurodegenerative disorders like Parkinson and Alzheimer diseases, Friedreich ataxia or Amyotrophic lateral sclerosis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Changes in metabolic state alter foraging behavior and food preference in animals. Here, I show that normally attractive food becomes repulsive to Caenorhabditis elegans if animals are chronically undernourished as a result of alimentary tract defects. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Common strategies for discovering the community structure of multi-mode networks identify the communities of each mode simultaneously. Here I show that this combined approach is ineffective at discovering community structures when there are an unequal number of communities between the modes of a multi-mode network. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Members of the Critical Neuroscience initiative raised the question whether the perceived normative significance of neuroscience is justified by the discipline’s actual possibilities. In this paper I show how brain research was assigned the ultimate political, social, and moral authority by some leading researchers who suggested that neuroscientists should change their research priorities, promising solutions to social challenges in order to increase research funds. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso