“…Such computational methods generally predict a densely connected kinase-substrate network, with most sites targeted by multiple kinases, pointing either to unaccounted-for biochemical constraints or significant cross-talk and signaling redundancy. I show that such predictions can potentially identify biased kinase-site misannotations within families of closely related kinase isozymes and they provide a robust basis for kinase activity analysis.…”
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“…The emphysema group (GS ≥ 1) showed better progression-free survival (PFS) than the non-emphysema group (GS = 0) (6.5 vs. 2.3 months, respectively, p < 0.01). …”
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“…One rhizobia clone of Sinorhizobium meliloti with Al tolerance (AT1) was isolated from the nodule in AlCl(3)-treated alfalfa roots. AT1 showed a higher growth rate than the standard rhizobia strain Sm1021 under Al-stressed conditions. …”
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“…However, PIDD1 appears to be able to engage with multiple client proteins to promote an even broader range of biological responses, such as NF-κB activation, translesion DNA synthesis or cell death. PIDD1 shows features of inteins, a class of self-cleaving proteins, to create different polypeptides from a common precursor protein that allow it to serve these diverse functions. …”
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“…Additionally, compound 18i showed good liver microsomal stability and did not significantly inhibit CYP and Herg. …”
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“…Theories suggest training should target processes that 1) show robust engagement, 2) are domain-general, and 3) reflect long-lasting changes in brain organization. …”
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“…On the other hand, compound 1 showed moderate cytotoxicity toward KB, Hep G2, and MCF7 cell lines with the IC(50) values of 23.5, 19.8, and 23.7 μM, respectively. …”
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“…Using a theoretical model, I show that the functional form of JCEs largely impacts their ability to maintain coexistence. …”
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“…Taking inspiration from Tine Gammeltoft’s description of how belonging entails fragile attempts at being part of something larger, and is thus a joint social practice, I show how one dimension of belonging’s fragility is the inability to be in synch with social time. …”
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“…The potential of new coumarin (1) as a selective inhibitor of MAO-B was initially evaluated through molecular docking and pharmacophore studies. Compound (1) showed selectivity for the MAO-B isoenzyme and inhibitory activity in the sub-micromolar range with an IC(50) value of 153.25 ± 1.58 nM (MAO-B selectivity index > 172).…”
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“…We identified three potential candidate gene variants (NSUN7, MTMR3, CEP162) and validated two variants in known CAKUT genes (GATA3 and FRAS1) showing strong enrichment in this severe phenotype population. …”
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“…These sequence variations led to changes in seed morphology, starch structure, starch crystallinity, amylopectin chain length distribution, digestibility, apparent amylose content (AAC), and resistant starch content (RS). SBE3 and GBSS1 showed genetic interaction in regulating AAC and RS. …”
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“…We have identified that DACH1 is abundantly expressed in developing HEV-type endothelial cells. DACH1 showed a restricted expression pattern in lymph node blood vessels during the late fetal and early neonatal periods, corresponding to HEV development. …”
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“…The results of Experiment 1 show that both post-encoding conditions have a similar effect on memory after 1 day. …”
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“…The synthesized Pd–Zn-ins/CNS were further employed as catalysts for selective hydrogenation of acetylene. Pd(3.9)Zn(6.1) showed the best catalytic performance compared with other Pd–Zn intermetallic forms.…”
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“…I propose that the NU implements a forward internal model to predict the activation of the otoliths, and outputs sensory predictions errors to correct internal estimates of self-motion or to drive learning. I show that a Kalman filter based on this framework accounts for various functions of the NU, neurophysiological findings, as well as the clinical consequences of NU lesions. …”
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“…Results are robust to partial identification methods applying varying assumptions about unobservable confounding, using information on confounding from observables including other types of child abuse. I show that associations between childhood sexual abuse and education outcomes and earnings are at least as large for males as for females. …”
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“…The results of the four cases show that the simulation and prediction errors of the new model are all less than 10%, and case 1 shows the best results of 1.56% and 2.07%, respectively, which are used to predict the carbon dioxide emissions in the next 5 years in Beijing. …”
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“…Across two experiments, we demonstrate that baboons (Papio papio) show a capacity for compositionality. Experiment 1 showed that baboons can entertain negative, compositional, representations: they can learn to associate a cue with iconically related referents (e.g., a blue patch referring to all blue objects), but also to the complement set associated with it (e.g., a blue patch referring to all non-blue objects). …”
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“…However, the future extinction magnitude has not been quantitatively estimated. Here, I show that the sixth major mass extinction (defined as > 60% species loss) will be avoided, but a minor mass extinction, 20–50% animal species loss (1% now), will occur when humans cause nuclear war and/or fail to stop increasing greenhouse gas (GHG) emissions, pollution, and deforestation until 2060–2080 CE. …”
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