“…We analyze, from a Jewish legal perspective, some of the ethical conundrums that society faces in pushing the outer limits in researching these new biotechnologies.…”
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“…PURPOSE: The outer limiting membrane (OLM) is considered to play a role in maintaining the structure of the retina through mechanical strength. …”
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“…We show that the adherens junctions between photoreceptors and Müller glia which comprise the retinal outer limiting membrane (OLM) are not uniformly formed in the Nrl(−/−) retina and thus allow protrusion of a population of developing photoreceptors into the subretinal space where their maturation becomes delayed. …”
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“…We therefore sought to assess whether the outer limiting membrane (OLM), a natural barrier between the subretinal space and the outer nuclear layer (ONL), could be reversibly disrupted and if disruption of this barrier could lead to enhanced numbers of transplanted photoreceptors integrating into the ONL. …”
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“…These findings provide an example of how combinatorial codes of transcription factors ensure precision in Hox‐mediated PCD in specific segments at the outer limits of Hox expression.…”
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“…First, in the context of judicial review, parliamentary privilege is defined by the outer limits of the principle of exclusive cognisance. …”
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“…This is challenging as the bivalent structure of PROTACs puts them in chemical space at, or beyond, the outer limits of oral druggable space. We used NMR spectroscopy and molecular dynamics (MD) simulations independently to gain insights into the origin of the differences in cell permeability displayed by three flexible cereblon PROTACs having closely related structures. …”
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“…The highest risk of disease transmission can be expected at the outer limits of the modeled total distribution range, where infection rates are high, but antibody presence is low, making many species susceptible to the pathogen. …”
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“…The challenges for planning in urban regions are: 1) specifying regulations that define outer limits to the development of each settlement unit, 2) comprehensive planning with focal points for development, and limiting access and development at other places, and 3) compensating for new soil sealing by restoring nearby sealed areas. …”
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“…In this sense, the outer limits of the ruins have been identified using photogrammetry and convergent drone flights. …”
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“…Nor molds or pathogens were identified in outer limits. Based on these results, fermented chili powders could be used as starter carriers in the production of fermented meat products for exceptional sensory properties and food safety management.…”
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“…Methods: 30 healthy individuals with skin type II/III were recruited; a younger cohort, aged 20–37 (n = 18) and an older cohort (n = 12), age 51–69 years. Exposure was at outer limits of sensible sun exposure designed to enhance vitamin D synthesis without increasing risk of photo ageing and non-melanoma skin cancer. …”
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“…BACKGROUND: Central place foragers (CPF) rest within a central place, and theory predicts that distance of patches from this central place sets the outer limits of the foraging arena. Many marine ectothermic predators behave like CPF animals, but never stop swimming, suggesting that predators will incur ‘travelling’ costs while resting. …”
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“…In addition to resolving the localization of enzymes in mitochondrial membranes, these data indicate that the outer limiting membrane of the mitochondrion is the sole determinant of the surface charge of mitochondria.…”
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“…In addition, logistic regression analyses indicated the corrections of ME recurrence with baseline macular volume and the disruption of the outer limiting membrane at the fovea. CONCLUSION: This study suggested that OCT parameters, including baseline macular volume and outer limiting membrane disruption, and reduction in CRT after loading therapy were more predictive of ME recurrence than FA patterns or visual changes following conbercept loading therapy.…”
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“…Overall, these findings highlight that breakdown of the outer limiting membrane could play an important role in exacerbating photoreceptor loss in the ventral retina. …”
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“…It is typically assumed that photoreceptor loss leads to an upregulation of glial fibrilliary acidic protein (Gfap) and other intermediate filament proteins, together with other gliosis-related changes, including loss of integrity of the outer limiting membrane (OLM) and deposition of proteoglycans. …”
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“…The T2 bacteriophage is shown to be composed of an outer limiting membrane and a cohesive semisolid fibrillar body substance, presumably nucleic acid, which can be drawn as a strand from the bacteriophage body.…”
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