“…Thus, the CRISPR-mediated genome reprogramming of plants, including its use in gene expression regulation through transcriptional repression or activation (CRISPRi and CRISPRa), could be of paramount importance for phytoremediation. The simplicity, inexpensiveness, and capabilities of this gene editing technique could soon be used to enhance plants and bacteria involved in phytotechnologies, such as phystabilization, phytoextraction, phytomining, phytovolatilization, and bio-energy generation. …”
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“…Since most spina bifida patients are surviving into adolescence and adulthood due to improved medical and surgical advancements, it is paramount for healthcare professionals to address issues related their sexual and reproductive function.…”
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“…Functional disorders are common, with irritable bowel syndrome (IBS) being the commonest and most extensively evaluated functional bowel disorder. It is therefore paramount that effective therapies are available to treat this common condition. …”
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“…Timely diagnosis and proper treatment are of paramount importance for a favorable outcome. Besides blood cultures, several laboratory tests have been developed in the hope of facilitating an earlier detection of infection. …”
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“…Among them, the intestinal microbiota and its metabolites have been recently identified as paramount in ALD pathophysiology. Ethanol abuse triggers qualitative and quantitative modifications in intestinal flora taxonomic composition, mucosal inflammation, and intestinal barrier derangement. …”
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“…Although porous concrete pavement design methods are mainly focused on maintaining high permeability rates in order to improve their ability to manage stormwater runoff, the mixture strength is paramount for its durability and service life. This paper proposes a new mixture design method for porous concrete, named PCD (porous concrete design), derived from the ACI 522R-10 and ACI 211.3R-02 standards. …”
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“…Understanding the underlying pathophysiological basis of disease activity and remission is paramount to help define better biomarkers of relapse, which should positively affect adverse events and patient outcomes.…”
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“…The problem of air quality is paramount in commercial office buildings while the problem of biocontamination is of the highest concern in the food industry. …”
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“…Demographic stability constitutes a paramount global environmental objective. Yet, decades of efforts, highlighting the perils of overpopulation, have failed to slow the rapid global population growth. …”
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“…Because the presence of biofilms can advance or hinder humanity’s space exploration efforts, an understanding of their impacts over the duration of space flights is of paramount importance.…”
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“…Their ability to locate hosts is paramount to successful infection and host seeking has been extensively studied in many species in the lab. …”
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“…The biochemical integrity of the brain is paramount to the function of the central nervous system, and oxidative stress is a key contributor to cerebral biochemical impairment. …”
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“…However, cross-border contexts imply paramount communication challenges, such as seamless roaming, not addressed by current technology. …”
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“…The surveillance for COVID-19 is paramount, and the guidelines such as the one published by the World Health Organization ‘Public health surveillance for COVID-19: interim guidance’ must be referred to. …”
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“…To understand how proteins function on a cellular level, it is of paramount importance to understand their structures and dynamics, including the conformational changes they undergo to carry out their function. …”
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“…Preparing well-defined semiconducting nanostructures from conjugated polymers is of paramount interest for organic optoelectronic devices. …”
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“…Improved understanding of intrinsic cellular changes, general senescence mechanisms, intercellular interactions and alterations in extracellular environment which occur with aging and impact oligodendrocyte cells is paramount. This may lead to strategies to support oligodendrocytes in aging, for example by supporting myelin synthesis, protecting against oxidative stress and promoting the rejuvenation of the intrinsic regenerative potential of progenitor cells. …”
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“…The importance of early identification and prevention of OCD during critical periods, such as the present one, is of paramount importance since this psychiatric condition is associated with a prolonged latency in the correct diagnosis and first professional contact which is in turn associated with worse prognosis and higher resistance to treatment.…”
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“…Global scientific collaboration andreporting of a validated tool for CAM is of paramount importance to increase theknowledge with regard to this emerging disease.…”
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“…CONCLUSION: The diagnosis of NSM is challenging, the role of histopathology and immunohistochemistry is of paramount importance.…”
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