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  1. 2281
    “…Colorectal cancer (CRC) is a leading cancer globally; therefore, early diagnosis and surveillance of this cancer are of paramount importance. Current methods of CRC diagnosis rely heavily on endoscopy or radiological imaging. …”
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    Roles of Methylated DNA Biomarkers in Patients with Colorectal Cancer
  2. 2282
    “…The work provides insights for integrating academic disciplines, the community, and relevant stakeholders in the cocreation of evidence that is paramount to formulate effective solutions to global challenges.…”
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    Participatory Action Research as a Framework for Transdisciplinary Collaboration: A Pilot Study on Healthy, Sustainable, Low‐Income Housing in Delhi, India
  3. 2283
    “…Therefore, understanding the properties of polytypic structures is of paramount importance for many promising applications in high-performance nanodevices. …”
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    Synthesis of Polytypic Gallium Phosphide and Gallium Arsenide Nanowires and Their Application as Photodetectors
  4. 2284
    “…In this context, the development of molecular tools is paramount to address and improve productivity, nutrition, and genetic breeding programs. …”
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    From the Amazon: A comprehensive liver transcriptome dataset of the teleost fish tambaqui, Colossoma macropomum
  5. 2285
    “…Clinicians should be vigilant for severe autonomic dysfunction as prompt etiology establishment is of paramount importance in these patients.…”
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    Anti-N-methyl-D-aspartate Receptor Encephalitis Associated with Ictal Torsades de Pointes and Cardiac Arrest
  6. 2286
    “…Anti‐angiogenic treatment has limited efficacy due to therapy‐induced blood vessel alterations, often followed by local hypoxia, tumor adaptation, progression, and metastasis. It is therefore paramount to overcome therapy‐induced resistance. We show that Apelin inhibition potently remodels the tumor microenvironment, reducing angiogenesis, and effectively blunting tumor growth. …”
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    Apelin inhibition prevents resistance and metastasis associated with anti‐angiogenic therapy
  7. 2287
    “…Detailed knowledge, institution of preventive measures, early recognition, and prompt treatment of adverse events during systemic therapy is of paramount importance. Documentation of patient characteristics, tumor characteristics, treatment details, and clinical and patient reported outcome is essential for monitoring the quality of care. …”
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    Best Practice in Systemic Therapy for Head and Neck Squamous Cell Carcinoma
  8. 2288
    “…In Ambient Intelligence (AmI), the activity a user is engaged in is an essential part of the context, so its recognition is of paramount importance for applications in areas like sports, medicine, personal safety, and so forth. …”
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    Multi-Sensor Fusion for Activity Recognition—A Survey
  9. 2289
    “…Therefore, developing feasible, sensitive and robust analytical methods is paramount for the identification and quantification of aflatoxins present in low concentrations in food and feed. …”
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    Aflatoxins in Food and Feed: An Overview on Prevalence, Detection and Control Strategies
  10. 2290
    “…To be better prepared for new epidemics, the WHO has compiled a list of priority pathogens that are likely to cause future outbreaks and for which R&D efforts are, therefore, paramount (R&D Blueprint: https://www.who.int/blueprint/priority-diseases/en/). …”
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    Recombinant vesicular stomatitis virus vector vaccines for WHO blueprint priority pathogens
  11. 2291
    “…Though haemosiderotic synovitis is an exceedingly rare condition, it must be considered following recurrent haemarthrosis as, due to its destructive nature, prompt recognition and treatment is paramount.…”
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    Haemosiderotic Synovitis Secondary to Anticoagulant Use: An Unusual Mechanism of Failure of a Unicompartmental Knee Replacement
  12. 2292
    “…Owing to this, the SGPEs showed high flexibility and strong mechanical stability. Some paramount physicochemical and electrochemical characters were observed. …”
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    Highly Conductive and Flexible Gel Polymer Electrolyte with Bis(Fluorosulfonyl)imide Lithium Salt via UV Curing for Li-Ion Batteries
  13. 2293
    “…Elucidating changes occurring in these tissues in response to injury or age is paramount to identify new therapies to better manage disc and spine degenerative conditions, including low back pain. …”
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    A step‐by‐step protocol for isolation of murine nucleus pulposus cells
  14. 2294
    “…Tuberculosis (TB) treatment monitoring is paramount to clinical decision-making and the host biomarkers appears to play a significant role. …”
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    Immune Biomarkers for Diagnosis and Treatment Monitoring of Tuberculosis: Current Developments and Future Prospects
  15. 2295
    “…For instance, recent work reveals that such secretion of small molecules by roots is of paramount importance to sculpt the rhizospheric microbiota. …”
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    The Multiple Facets of Plant–Fungal Interactions Revealed Through Plant and Fungal Secretomics
  16. 2296
    “…Identification of drug binding targets, within the complex milieu of the human proteome, remains a challenging task of paramount importance in drug discovery. Existing approaches for target identification employ complex workflows with limited throughput. …”
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    An isothermal shift assay for proteome scale drug-target identification
  17. 2297
    “…An effective and definite surgical repair is of paramount importance in order to avoid life-threatening complications, improve patient’s and caregiver’s quality of life, and avoid unnecessary health-system costs.…”
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    Endoscopic Surgical Repair of a Giant, Postoperative, Neglected Meningoencephalocele
  18. 2298
    “…CONCLUSION: Acknowledging and managing these differences is paramount because they influence shared decision-making and may affect patient outcomes in the short term, as well as their more general well-being in the long term.…”
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    Qualitative Study of Factors Affecting Patient, Caregiver and Physician Preferences for Treatment of Myeloma and Indolent Lymphoma
  19. 2299
    “…Solubility is an important, albeit not well understood, feature determining protein behavior. It is of paramount importance in protein engineering, where similar folded proteins may behave in very different ways in solution. …”
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    SODA: prediction of protein solubility from disorder and aggregation propensity
  20. 2300
    “…Broadening our research strategies regarding the assessment of anxiety is paramount to clarify the role of anxiety in SM, and allow for proper classification. …”
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    Anxiety in Children with Selective Mutism: A Meta-analysis
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