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  1. 2321
    “…In this context, clustering of TCRs by sequence to reflect biological similarity, and especially to reflect antigen specificity have become of paramount importance. We review the main TCR sequence clustering methods and the different similarity measures they use, and discuss their performance and possible improvement. …”
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    T cell receptor sequence clustering and antigen specificity
  2. 2322
    “…Given that a balance between all these processes contributes to the maintenance of retinal homeostasis, effective regulation of riboflavin levels in the retina is paramount. However, various genetic and dietary factors have brought to fore pathological conditions that co-occur with a suboptimal level of flavins in the retina. …”
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    Flavins Act as a Critical Liaison Between Metabolic Homeostasis and Oxidative Stress in the Retina
  3. 2323
    “…The development of synthetic strategies to engineer π-conjugated polymers is of paramount importance in modern chemistry and materials science. …”
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    Tailoring π-conjugation and vibrational modes to steer on-surface synthesis of pentalene-bridged ladder polymers
  4. 2324
    “…BACKGROUND: Ebstein’s anomaly (EA) is mainly thought of as a right heart condition, however, congenital left-sided lesions can co-exist. Therefore, it is paramount to include the left side of the heart as part of a routine investigation in these patients. …”
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    Left heart matters in Ebstein’s anomaly: the importance of a closer follow up—a case report
  5. 2325
    por Coman, Vasile, Vodnar, Dan Cristian
    Publicado 2020
    “…Our gut microbiota is a complex and dynamic ecosystem with a paramount role in shaping our metabolic and immunological functions. …”
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    Gut microbiota and old age: Modulating factors and interventions for healthy longevity
  6. 2326
    por Saini, Varinder, Garg, Kranti
    Publicado 2020
    “…We are still far from reaching the goals so set as per End TB Strategy and National Strategic Plan 2017–2025, and case finding is of paramount importance for achieving the said targets. …”
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    Case finding strategies under National Tuberculosis Elimination Programme (NTEP)
  7. 2327
    por Curling, S. F., Ormondroyd, G. A.
    Publicado 2020
    “…The major implication is that to ensure serviceability of wood and wooden structures exposed to the environment the use of good design, durable woods and properly treated or modified woods will be paramount.…”
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    Observed and projected changes in the climate based decay hazard of timber in the United Kingdom
  8. 2328
    “…BUAN builds networks of bundle shape similarities that can be paramount for automating quality control. BUAN is freely available in DIPY. …”
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    Bundle analytics, a computational framework for investigating the shapes and profiles of brain pathways across populations
  9. 2329
    “…Herein, we present our perspectives on the effect of regular supplementation with the biological response modifier beta glucan based on its relevance to immune modulation. This effect is of paramount importance in decreasing the development of severe COVID-19 and reducing mortality against the background of coagulopathy, especially in vulnerable populations.…”
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    Coagulopathy associated with COVID-19 – Perspectives & Preventive strategies using a biological response modifier Glucan
  10. 2330
    “…In the opinion of authors, minimizing the time to treatment with 4F-PCCs is of paramount importance when treating patients with VKA-related bleeding. …”
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    Optimal Dosage and Administration Practices for Vitamin K Antagonist Reversal With 4-Factor Prothrombin Complex Concentrate
  11. 2331
    “…The results demonstrate that maximizing absorption and emission processes remains paramount for optimizing devices.…”
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    Effect of Perovskite Thickness on Electroluminescence and Solar Cell Conversion Efficiency
  12. 2332
    por Sahlberg, Pasi
    Publicado 2020
    “…I argue that as we think about how education should be reimagined, it is paramount to continue efforts to make education more inclusive, fairer and equitable for all. …”
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    Does the pandemic help us make education more equitable?
  13. 2333
    “…Understanding the immunosuppressive mechanisms within the TME is paramount to overcoming these obstacles. T cell senescence is a critical dysfunctional state present in the TME that differs from T cell exhaustion currently targeted by many immunotherapies. …”
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    Senescent Tumor CD8(+) T Cells: Mechanisms of Induction and Challenges to Immunotherapy
  14. 2334
    “…In this context, epidemiological and molecular evolution data are paramount to decipher the diffusion route of this DENV-2 in the South Pacific region. …”
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    Molecular Characterization of Dengue Type 2 Outbreak in Pacific Islands Countries and Territories, 2017–2020
  15. 2335
    “…Because the response of bone to mechanical signals is dependent on functional estrogen receptor (ER) and Wnt/β-catenin signaling and is impaired in postmenopausal osteoporosis by estrogen deficiency, it is of paramount importance to elucidate the underlying mechanisms as a basis for the development of new strategies in the treatment of osteoporosis. …”
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    Effects of Estrogen Receptor and Wnt Signaling Activation on Mechanically Induced Bone Formation in a Mouse Model of Postmenopausal Bone Loss
  16. 2336
    “…Understanding the molecular events controlling melanoma progression is of paramount importance for the development of alternative treatment options for this devastating disease. …”
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    ST3GAL1 is a target of the SOX2-GLI1 transcriptional complex and promotes melanoma metastasis through AXL
  17. 2337
    “…Although transport across BECs is of paramount importance for nutrient uptake as well as ridding the brain of waste products, the intracellular sorting mechanisms that regulate successful receptor-mediated transcytosis in BECs remain to be elucidated. …”
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    On the shuttling across the blood-brain barrier via tubule formation: Mechanism and cargo avidity bias
  18. 2338
    “…The expression and regulation of matrisome genes—the ensemble of extracellular matrix, ECM, ECM-associated proteins and regulators as well as cytokines, chemokines and growth factors—is of paramount importance for many biological processes and signals within the tumor microenvironment. …”
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    Machine Learning Identifies Robust Matrisome Markers and Regulatory Mechanisms in Cancer
  19. 2339
    “…A correct assessment of the valve disease severity is key to define the need for aortic valve replacement (AVR), but a better understanding of the myocardial consequences of the increased afterload is paramount to optimize the timing of the intervention. …”
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    Multimodality Imaging for Discordant Low-Gradient Aortic Stenosis: Assessing the Valve and the Myocardium
  20. 2340
    por Ferreira, Rosario
    Publicado 2020
    “…Long-term non-invasive ventilation (LTNIV) has been increasingly used in children to manage chronic respiratory failure and airway obstruction. Interfaces are of paramount importance for non-invasive ventilation (NIV) effectiveness and patient compliance. …”
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    Interfaces, Circuits and Humidifiers
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