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  1. 2341
    “…Due to the high degree of personal information gathered for such initiatives, privacy-sensitive implementation choices and ethical standards are paramount. The Personal Genetic Locker project provides an approach to enable the use of personal genomic data in primary care. …”
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    Using Personal Genomic Data within Primary Care: A Bioinformatics Approach to Pharmacogenomics
  2. 2342
    “…This case discusses whether the prolapse was preexisting and led to overstaging the tumor or whether the prolapse is a new-onset complication of the radiotherapy. It seems of paramount importance to detect preexisting rectal prolapse to avoid overstaging. …”
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    Rectal prolapse following short-course radiotherapy for rectal cancer: report of a case
  3. 2343
    por Jiang, Wei, Chen, Liang
    Publicado 2020
    “…Given the importance of alternative splicing events, their accurate mapping and quantification are paramount for downstream analysis, especially for associating disease with alternative splicing. …”
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    Alternative splicing: Human disease and quantitative analysis from high-throughput sequencing
  4. 2344
    “…Thus, prompt evaluation and a high index of suspicion are of paramount importance to prevent unwanted sequelae.…”
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    Ruptured Heterotopic Pregnancy: A Rare Encounter in Acute Surgical Care Settings
  5. 2345
    “…Preservation of periodontal health after periodontal therapy is paramount for the complete elimination of periodontal diseases. …”
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    Role of Communication, Professionalism, and Clinical Care Skills of Postgraduate Students on Patients Recall Visits in Dental School—An Observational Study
  6. 2346
    “…Controlling plasma cholesterol levels and other metabolic risk factors is of paramount importance to prevent the overall burden of disease emerging from cardiovascular-disease-related morbidity and mortality. …”
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    Regulation of Cholesterol Metabolism by Bioactive Components of Soy Proteins: Novel Translational Evidence
  7. 2347
    “…History of coronary artery disease is related to increased CV mortality following LT. Although it is of paramount importance to stratify CV risk in pre-LT patients, there is no consensus regarding the choice of the optimal non-invasive cardiac imaging test. …”
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    Preoperative Evaluation of Coronary Artery Disease in Liver Transplant Candidates: Many Unanswered Questions in Clinical Practice
  8. 2348
    “…More effective methods to detect bovine tuberculosis, caused by Mycobacterium bovis, in wildlife, is of paramount importance for preventing disease spread to other wild animals, livestock, and human beings. …”
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    Non-Invasive Method to Detect Infection with Mycobacterium tuberculosis Complex in Wild Boar by Measurement of Volatile Organic Compounds Obtained from Feces with an Electronic Nose System
  9. 2349
    por Liu, Haomin, Lei, Yu
    Publicado 2021
    “…Detection of a single biomolecule, ranging from nucleic acids, proteins, viruses to bacteria, is of paramount importance in various fields including biology, environment, food and agriculture industry, public health, and medicine. …”
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    A critical review: Recent advances in “digital” biomolecule detection with single copy sensitivity
  10. 2350
    “…Because of its impact on human health, understanding the molecular mechanism of C-type inactivation in hERG represents an advance of paramount importance. Here, long–time scale molecular dynamics simulations, free energy landscape calculations, and electrophysiological experiments are combined to address the structural and functional impacts of several disease-associated mutations. …”
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    Mechanism of C-type inactivation in the hERG potassium channel
  11. 2351
    “…The development of novel therapeutic strategies that improve the life quality of affected individuals is therefore of paramount importance. Cell transplantation is a promising approach for spinal cord injury treatment and the present study assesses the efficacy of human embryonic stem cell–derived neural crest cells as preclinical cell-based therapy candidates. …”
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    Human Embryonic Stem Cell–derived Neural Crest Cells Promote Sprouting and Motor Recovery Following Spinal Cord Injury in Adult Rats
  12. 2352
    “…Large optical anisotropy observed in a broad spectral range is of paramount importance for efficient light manipulation in countless devices. …”
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    Giant optical anisotropy in transition metal dichalcogenides for next-generation photonics
  13. 2353
    por Kajonius, Petri J., Johnson, John A.
    Publicado 2019
    “…Testing the structural validity of trait measurements is paramount in this endeavor. In the current study, we investigated 30 facet traits in one of the accessible and comprehensive public-domain Five Factor Model (FFM) personality inventories, IPIP-NEO-120 (Johnson, 2014), using one of the largest US samples to date (N = 320,128). …”
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    Assessing the Structure of the Five Factor Model of Personality (IPIP-NEO-120) in the Public Domain
  14. 2354
    “…Maintaining strict NPIs throughout 2021 is of paramount importance to reduce COVID-19 burden while vaccines are distributed to the population, especially in large populations with little natural immunity.…”
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    Can a COVID-19 vaccination program guarantee the return to a pre-pandemic lifestyle?
  15. 2355
    “…Therefore, it is of paramount importance to individualize treatment via risk stratification. …”
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    Assessing Cardiovascular Risk in Patients with Diabetes: An Update
  16. 2356
    “…Increasing physical activity is of paramount importance for achieving the objectives formulated in relation to sustainability.…”
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    Sustainability-Sport-Physical Activity
  17. 2357
    “…RECENT FINDINGS: In the current SARS-CoV2 epidemiological environment, infection control and costs associated with healthcare-associated infections (HAIs) are of paramount importance. Even before the onset of SARS-CoV2, HAIs affected nearly 2million patients a year in the USA and resulted in nearly 90,000 deaths, all of which resulted in a cost to hospitals ranging from US$28 billion to 45 billion. …”
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    Disinfectants In Interventional Practices
  18. 2358
    “…It highlights not only the importance of recognizing and accurately diagnosing SCAD, but also of appreciating the possibility of underlying arteriopathy: this is paramount to ensuring appropriate investigations, follow-up and assessment of any unexplained symptoms in this patient group.…”
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    Simultaneous spontaneous arterial dissections in a 38-year-old woman presenting during the covid-19 pandemic: a case report
  19. 2359
    “…Increase of alliinase stability and its activity are of paramount importance in various applications relying on its use for in-situ synthesis of allicin or its analogues, e.g., pulmonary drug delivery, treatment of superficial injuries, or urease inhibitors in fertilizers. …”
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    Effect of physicochemical parameters on the stability and activity of garlic alliinase and its use for in-situ allicin synthesis
  20. 2360
    “…Personalized medicine is a nascent area of research and represents a paramount challenge in the treatment and cure of PD. …”
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    Advancing Personalized Medicine in Common Forms of Parkinson’s Disease through Genetics: Current Therapeutics and the Future of Individualized Management
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