“…Understanding how hypoxia triggers the GBM cells to become invasive is paramount to developing novel and more effective therapies against this devastating disease. …”
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“…In the face of increasingly serious environmental pollution problems, scholars have conducted a significant quantity of related research, and in those studies, the forecasting of air pollution has been of paramount importance. As a precaution, the air pollution forecast is the basis for taking effective pollution control measures, and accurate forecasting of air pollution has become an important task. …”
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“…The quantification of changes in geomechanical properties due to chemical reactions is of paramount importance for geological subsurface utilisation, since mineral dissolution generally reduces rock stiffness. …”
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“…The possibility to apply this technique to 2D materials is of paramount importance because these ultrathin layers are considered fundamental for future electronic, photonic and spintronic devices. …”
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“…Discriminating between the different binding patterns is of paramount importance to predict and rationalize the effect of a given compound on DNA. …”
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“…These diffusion processes are of paramount importance for cells, as they are for example involved in cell signaling processes or the recycling of membrane components, but also for recently developed analytical approaches, which use differences in the mobility for certain analytical purposes, such as in-membrane purification of membrane proteins or the analysis of multivalent interactions. …”
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“…The identification and use of species that have best adapted to their growth territory is of paramount importance to preserve biodiversity while promoting sustainable agricultural practices. …”
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“…Added to the volume and the heterogeneous exchange and consumption of data, it is paramount to assure that data quality levels are maintained in every step of the data chain/lifecycle. …”
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“…This review covers the history and current advances in the diagnosis and management of stone disease in pregnant and pediatric populations. It is paramount for the urologist to understand the complexities of properly managing stones in these patients in order to maximize treatment efficacy, while minimizing complications and morbidity.…”
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“…Because of their potential use as functional ingredients in human nutrition, oligosaccharides derived from natural sources are receiving paramount consideration. Red seaweed, a proven rich source of agar and carrageenan, is one of the most abundantly present sources of such oligosaccharides. …”
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“…Nowadays a recognized need for accurate observations of atmospheric aerosols (AEs) and reactive gases (RGs) exists in the framework of regional, national and global near-surface networks based on permanent or mobile measurement stations. In this context, a paramount and not-trivial issue is related to the correct execution of continuous sampling of ambient air and its subsequent distribution to measurement analyzers hosted inside the stations. …”
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“…Cybersecurity is becoming a key enabler for safety, which is paramount in the aviation context. Smart airports strive to provide optimal services in a reliable and sustainable manner, by working around the domains of growth, efficiency, safety and security. …”
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“…Deciphering the molecular basis of such adverse responses is not only paramount to the development of safer drugs but also presents a unique opportunity to dissect disease systems in search of novel response biomarkers, drug targets, and efficacious combination therapies. …”
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“…The study of compounds able to interfere in various ways with amyloid aggregation is of paramount importance in amyloid research. Molecules characterized by a 4-thiaflavane skeleton have received great attention in chemical, medicinal, and pharmaceutical research. …”
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“…This review describes the paramount discoveries obtained through the application of different α-syn models of PD in C. elegans and highlights their established utility and respective promise to successfully uncover new conserved genetic modifiers, functional mechanisms, therapeutic targets and molecular leads for PD with the potential to translate to humans.…”
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“…This post-translational modification is paramount for the correct biological function of ion channel toxins and antimicrobial peptides, among others. …”
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“…These results contribute to an improved understanding of the benefits of limiting global warming to the 2.0 °C/1.5 °C targets, which is paramount for mitigation and adaptation planning.…”
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“…Bearing in mind that time constraints constitute a crucial parameter in search and rescue (SAR) missions, the punctual and precise detection of humans in peril is of paramount importance. The paper in hand deals with real-time human detection onboard a fully autonomous rescue UAV. …”
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“…We deem this result is of paramount importance for the management of the Mo.S.E. barriers and for the definition of their operating strategy aiming at preventing the flooding at all the urban settlements of the lagoon.…”
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“…Addressing such channels is of paramount importance, both in itself, since high-altitude imaging, environmental conditions, and imaging systems trade-offs lead to low-quality observation, as well as to facilitate subsequent analysis, such as classification and detection. …”
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