“…Efficient translation of -omics data and accumulated knowledge to clinical decision-making are of paramount scientific and public health interest. Well-structured translational algorithms are needed to bridge the gap from databases to decisions. …”
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“…Understanding prescribing guidelines and awareness of black box warnings is paramount for prescribers. Adherence to proper oversight will ensure Flibanserin can fulfil an unmet need for an FDA approved prescription medication for the treatment of HSDD in premenopausal women.…”
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“…Echocardiographic evaluation of PEff is paramount for timely and appropriate diagnosis and management. …”
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“…RESULTS: ‘Model-based Recursive Partitioning’ recognized the largest number of significant affective risk factors, whereas, all four parametric models agreed and unable to detect the effectiveness of ‘Progesterone Receptor’ as an indicator; ‘Log-Normal-based Recursive Partitioning’ could provide the paramount fit. CONCLUSION: The superiority of ‘Model-based Recursive Partitioning’ was ascertained; not only by its excellent fitness but also by its susceptibility for classification of individuals to homogeneous severity levels and its impressive visual intuition potentiality.…”
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“…This separation in terms of innovators and developers raises an issue of paramount importance: under which conditions a system is able to maintain innovators? …”
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“…The cofactor balances in metabolism is of paramount importance in the design of a metabolic engineering strategy and understanding the regulation of metabolism in general. …”
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“…Understanding the mechanisms that govern thymic regeneration is of paramount interest for the recovery of a functional immune system notably after bone marrow transplantation (BMT). …”
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“…To enable replication research, it is of paramount importance to carefully study the reliability of the instruments we use. …”
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“…Thus, alternative physiological patterns of hematopoiesis and bone marrow cell outputs depend on the expression of ACKR1 in the erythroid lineage providing major implications for the selection advantages that have resulted in the paramount fixation of the rs2814778(G) polymorphism in Africa.…”
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“…Achieving and controlling strong light-matter interactions in many-body systems is of paramount importance both for fundamental understanding and potential applications. …”
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“…Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a paramount role in the degradation of low-density lipoprotein (LDL) receptors (LDLR) on the hepatic cells surface and subsequently affects LDL particles catabolism and LDL cholesterol (LDL-c) levels. …”
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“…Key findings and conclusions: Structure of the skeleton as well as functional groups were paramount related with the bio-activity of TFs. Meanwhile, oxidation pathway of two catechin molecules to form TFs were hypothesized. …”
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“…Accurate detection of these mutants in heterogeneous tumor tissue is paramount as therapies emerge to target mutant p53. …”
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“…The aims of these guidelines are to provide the know-how for effectively controlling the quality of PET/CT scans in multicenter studies, to standardize the QC, to give sponsors and regulatory agencies a basis for justification of the data quality when using standardized uptake values as an imaging biomarker, to document the compliance with the imaging guidelines, to verify the per protocol population versus intent to treat population, and to safeguard the validity of multicenter study conclusions employing standardized uptake value (SUV) as an imaging biomarker which is paramount to the scientific community. Following the proposed guidelines will ensure standardized prospective imaging QC of scans applicable to most studies where SUVs are used as an imaging biomarker. …”
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“…Achieving accurate and efficacious tumor targeting with minimal off-target effects is of paramount importance in designing diagnostic and therapeutic agents for cancer. …”
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“…Ensuring access to an appropriate IDT, in whatever form, is paramount to enable the best care to be delivered.…”
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“…Improving ZIKV detection during outbreaks is of paramount importance because identification of the mosquito species and population involved as vector in a given outbreak is a key element to a comprehensive and effective vector control strategy.…”
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“…We then collaborated to develop the following nine guidelines: (1) Whenever possible, research should be grounded, from inception to dissemination, in a meaningful collaboration with community stakeholders; (2) language and framing of transgender health research should be non-stigmatizing; (3) research should be disseminated back to the community; (4) the diversity of the transgender and gender diverse (TGGD) community should be accurately reflected and sensitively reflected; (5) informed consent must be meaningful, without coercion or undue influence; (6) the protection of participant confidentiality should be paramount; (7) alternative consent procedures should be considered for TGGD minors; (8) research should align with current professional standards that refute conversion, reorientation, or reparative therapy; and (9) IRBs should guard against the temptation to avoid, limit, or delay research on this subject.…”
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“…The results obtained from this study allow us to infer stress under several working condition scenarios and to identify the more relevant variables in order to reduce this stress in healthcare professionals, which is of paramount importance to managing the stress of workers in this sector. …”
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“…Besides size, factors like flexibility and compliance to attach and adapt to visceral nerves associated moving organs are of paramount importance and have not been previously addressed. …”
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