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  1. 2821
    “…We anticipate that oxoTCO will find use in studies where hydrophilicity and fast bioconjugation kinetics are paramount.…”
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    Computationally guided discovery of a reactive, hydrophilic trans-5-oxocene dienophile for bioorthogonal labeling
  2. 2822
    “…Our study shows that thermal conditions are not paramount in habitat selection of box turtles, but that cooler temperatures do not have an effect on the extent of their locomotion.…”
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    Thermoregulatory performance and habitat selection of the eastern box turtle (Terrapene carolina carolina)
  3. 2823
    “…As climate change and other anthropogenic factors increase the uncertainty of vegetation ecosystem persistence, the ability to rapidly assess their dynamics is paramount. Vegetation and sessile communities form a variety of striking regular spatial patterns such as stripes, spots and labyrinths, that have been used as indicators of ecosystem current state, through qualitative analysis of simple models. …”
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    Conservation of pattern as a tool for inference on spatial snapshots in ecological data
  4. 2824
    “…Early and accurate diagnosis of malaria is of paramount importance to ensure appropriate administration of treatment. …”
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    Diagnostic tools in childhood malaria
  5. 2825
    “…Healthy people of all ages should be encouraged to adopt a healthy lifestyle, as well as improved lifestyle and reduced risk factor levels are paramount in patients at increased risk of developing cardiovascular disease (CVD) and in those with established CVD. …”
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    Main messages for primary care from the 2016 European Guidelines on cardiovascular disease prevention in clinical practice
  6. 2826
    “…[Image: see text] Uniformly controlling a large number of metal nanostructures with a plasmonically enhanced signal to generate quantitative optical signals and the widespread use of these structures for surface-enhanced Raman scattering (SERS)-based biosensing and bioimaging applications are of paramount importance but are extremely challenging. …”
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    Dealloyed Intra-Nanogap Particles with Highly Robust, Quantifiable Surface-Enhanced Raman Scattering Signals for Biosensing and Bioimaging Applications
  7. 2827
    “…Since β-cell failure is the root cause of diabetes, understanding this heterogeneity is of paramount importance. Recent reports have cataloged human islet transcriptome but not compared single β-cells in detail. …”
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    Single-cell analyses of human islet cells reveal de-differentiation signatures
  8. 2828
    “…Timely referral to a surgical oncologist and infectious diseases specialist is paramount in achieving satisfactory clinical outcomes.…”
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    Skull base or cervical vertebral osteomyelitis following chemoradiotherapy for pharyngeal carcinoma: A serious but treatable complication
  9. 2829
    “…Having explored the case of Punta Tarifa, we suggest that a cultural–geographical reading – and hence the shedding of some light – on these and other similar invisibilisation processes is paramount in order to neutralise symbolic and functional exclusionary practices which lie at the heart of current European Union external bordering dynamics.…”
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    The borderscape of Punta Tarifa: concurrent invisibilisation practices at Europe’s ultimate peninsula
  10. 2830
    “…Thus, a review of factors associated with the holistic management of schizophrenia is of paramount importance. The objective of this review is to improve the quality of life of individuals with schizophrenia, by addressing the factors related to the needs of the patients and present them in a unified manner. …”
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    Holistic Management of Schizophrenia Symptoms Using Pharmacological and Non-pharmacological Treatment
  11. 2831
    “…The considerable energetic disadvantage for piping through these thick eggshells suggests that their dissolution during incubation would have been paramount for a successful hatching.…”
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    Biomechanical evidence suggests extensive eggshell thinning during incubation in the Sanagasta titanosaur dinosaurs
  12. 2832
    “…Ex vivo expansion and differentiation of human pancreatic β-cell are enabling steps of paramount importance for accelerating the development of therapies for diabetes. …”
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    Cluster-assembled zirconia substrates promote long-term differentiation and functioning of human islets of Langerhans
  13. 2833
    “…As the use of ecoacoustic indices presents a promising tool for the monitoring of vulnerable environments, methodological validations like those presented in this paper are of paramount importance in understanding which biologically important information can be gathered by applying acoustic indices to Passive Acoustic Monitoring data.…”
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    Acoustic Complexity of vocal fish communities: a field and controlled validation
  14. 2834
    “…There are a number of modifiable factors that can mitigate some of the muscle loss elderly experience especially when hospitalized. Due to this, it is paramount for providers to understand the pathophysiology behind malnutrition and sarcopenia, be able to assess risk factors for malnutrition, and provide appropriate nutrition support. …”
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    Current perspective for tube feeding in the elderly: from identifying malnutrition to providing of enteral nutrition
  15. 2835
    “…Our results improve the understanding of future vulnerability to, and risk of, climate extremes, which is paramount for mitigation and adaptation activities for the global monsoon region where nearly two-thirds of the world’s population lives.…”
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    Reduced exposure to extreme precipitation from 0.5 °C less warming in global land monsoon regions
  16. 2836
    “…Understanding the neurobiological substrates of these behavioral deficits is of paramount importance to our understanding of addiction. …”
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    The impact of drugs of abuse on executive function: characterizing long-term changes in neural correlates following chronic drug exposure and withdrawal in rats
  17. 2837
    “…From the viewpoint of drug development, assessment of response to neoadjuvant chemotherapy remains paramount and appropriate assessment of residual disease—the primary endpoint of many drug therapy trials in the neoadjuvant setting—is critical. …”
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    Surgical Standards for Management of the Axilla in Breast Cancer Clinical Trials with Pathological Complete Response Endpoint
  18. 2838
    “…Thus, presence of mechanoreceptors is one of the factors having paramount importance for successful outcome. We conducted this study to identify mechanoreceptors via immunohistochemical staining and correlate their presence with duration of injury. …”
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    Quantitative correlation of mechanoreceptors in tibial remnant of ruptured human anterior cruciate ligament with duration of injury and its significance: an immunohistochemistry-based observational study
  19. 2839
    por Johnson, Brian R.
    Publicado 2018
    “…An appreciation of the importance of TRGs will improve our understanding of evolution by triggering the study of neglected topics in which TRGs are of paramount importance.…”
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    Taxonomically Restricted Genes Are Fundamental to Biology and Evolution
  20. 2840
    “…An understanding of the available data regarding the performance of each of the available OAC in a variety of at risk patient populations is paramount for the safe and effective management of this patient population. …”
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    Anticoagulation for Stroke Prevention in Older Adults with Atrial Fibrillation and Comorbidity: Current Evidence and Treatment Challenges
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