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  1. 2841
  2. 2842
    “…Therefore, to understand the molecule mechanism underlying invasion and metastasis is paramount for developing strategies to improve survival and prognosis in BC patients. …”
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  3. 2843
    “…In some patients, prompt intervention targeted at a specific etiology is of paramount importance. PRESENTING CONCERNS OF THE PATIENTS: A 25 years old man with advanced liver cirrhosis caused by sclerosing cholangitis and autoimmune hepatitis underwent orthotopic liver transplantation. …”
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  4. 2844
    “…Given the immensity of Brazil, knowledge of the epidemiological context of pulmonary fungal infections in the various regions of the country is paramount when considering their differential diagnoses. …”
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  5. 2845
    “…Community detection from molecular biological data is paramount in characterizing evolutionary and functional traits of organisms based on gene homology and co-expression, respectively. …”
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  6. 2846
  7. 2847
    “…Careful patient selection and respect for normal anatomy are of paramount importance in obtaining excellent outcomes in operations within or adjacent to the brainstem. …”
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  8. 2848
    por Dalmazzo, David, Ramírez, Rafael
    Publicado 2019
    “…Gestures in music are of paramount importance partly because they are directly linked to musicians' sound and expressiveness. …”
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  9. 2849
    por Hinnen, Deborah, Kruger, Davida F
    Publicado 2019
    “…Additionally, CVD remains the leading cause of death in patients with T2D, so it is paramount to determine the relationship between these two diseases. …”
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  10. 2850
    “…The prevention of the infection is of paramount importance in the linkage to care of the HCV population at risk and is an element which should always be associated with the drug treatment. …”
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  11. 2851
  12. 2852
    por Rodríguez-Merchán, E. Carlos
    Publicado 2019
    “…Early continuous haematological primary prophylaxis by means of the intravenous infusion of the deficient coagulation factor (ideally from cradle to grave) is of paramount importance because the immature skeleton is very sensitive to the complications of haemophilia: severe structural deficiencies may develop quickly. …”
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  13. 2853
    “…Given the central role of ghrelin in regulating feeding behaviors, and the altered ghrelin levels associated with metabolic disorders such as obesity and anorexia, it is of paramount relevance to understand the effects of ghrelin on synaptic plasticity of neuronal circuits associated with feeding behaviors.…”
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  14. 2854
    “…Doping adds a degree of freedom for their design and enables us to fully decouple their absorption and emission functions. This is paramount for luminescent solar concentrators (LSCs) that enable fabrication of electrode-less solar windows for building-integrated photovoltaic applications. …”
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  15. 2855
    “…The training intensity distribution (TID) of endurance athletes has retrieved substantial scientific interest since it reflects a vital component of training prescription: (i) the intensity of exercise and its distribution over time are essential components for adaptation to endurance training and (ii) the training volume (at least for most endurance disciplines) is already near or at maximum, so optimization of training procedures including TID have become paramount for success. This paper aims to elaborate the polarization-index (PI) which is calculated as log(10)(Zone 1/Zone 2(∗)Zone 3(∗)100), where Zones 1–3 refer to aggregated volume (time or distance) spent with low, mid, or high intensity training. …”
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  16. 2856
    “…The development of a suitable formulation able to control the GFs release rate, to protect the GFs, and to assure their prolonged contact with the wound site, is of paramount im-portance for the therapeutic success. …”
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  17. 2857
    “…The unveiling of their tuning principles is paramount towards a comprehension of not only their optical and radio frequency dielectric tunability, but also for the creation of EC structures with substantial permittivity tuning ratios. …”
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  18. 2858
    “…Alzheimer’s disease (AD) is the most prevalent form of neurodegenerative disorders, yet no major breakthroughs have been made in AD human trials and the disease remains a paramount challenge and a stigma in medicine. Here we eliminate the toxicity of amyloid beta (Aβ) in a facile, high-throughput zebrafish (Danio rerio) model using casein coated-gold nanoparticles (βCas AuNPs). βCas AuNPs in systemic circulation translocate across the blood brain barrier of zebrafish larvae and sequester intracerebral Aβ(42) and its elicited toxicity in a nonspecific, chaperone-like manner. …”
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  19. 2859
    “…A thorough clinical history examination including past medical history, HIV/AIDS (Acquired immunodeficiency syndrome) progression status, and a careful clinical exam are paramount to an early diagnosis and timely medical treatment.…”
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  20. 2860
    “…Another important key point of VLCKD is the ability to preserve fatty free mass which is known to play a role of paramount importance in glucose metabolism. Despite the clinical evidence of VLCKD there are paucity of data regarding to its management. …”
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