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  1. 2901
    “…Fast and effective first-line management is of paramount importance, particularly in the at-home management of seizures where drug administration routes are limited. …”
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    First-line management of canine status epilepticus at home and in hospital-opportunities and limitations of the various administration routes of benzodiazepines
  2. 2902
    “…Knowledge of the current state of evidence‐based lipid management after ACS is of paramount importance to improve outcomes after ACS.…”
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    Lipid Management in Patients Presenting With Acute Coronary Syndromes: A Review
  3. 2903
    “…The importance of polymeric nanocarriers in the field of drug delivery is ever-increasing, and the accurate characterization of their properties is paramount to understand and predict their behavior. …”
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    Asymmetric flow field-flow fractionation as a multifunctional technique for the characterization of polymeric nanocarriers
  4. 2904
    “…Hence, prevention of hypoxemia is of paramount importance. Traditionally, standard nasal cannula is used to administer supplement oxygen. …”
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    Recent Developments in Devices Used for Gastrointestinal Endoscopy Sedation
  5. 2905
    “…Cell factory design requires to define the optimal operational and cultivation conditions. The paramount parameter in biomass cultivation in photobioreactors is the light intensity since it impacts cellular physiology and productivity. …”
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    Computational Analysis of Dynamic Light Exposure of Unicellular Algal Cells in a Flat-Panel Photobioreactor to Support Light-Induced CO(2) Bioprocess Development
  6. 2906
    “…Therefore, elucidation of the molecular networks that drive aging is of paramount importance to human health. Progress toward this goal has been aided by studies from simple model organisms such as Saccharomyces cerevisiae. …”
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    Advances in quantitative biology methods for studying replicative aging in Saccharomyces cerevisiae
  7. 2907
    “…Therefore, it is of paramount importance to find an alternative approach for strain differentiation. …”
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    Fungal Genomic Resources for Strain Identification and Diversity Analysis of 1900 Fungal Species
  8. 2908
    “…The recognition of this disease entity proves even more crucial now amidst the ongoing global wave of COVID-19 infection. It is paramount to identify these patients early, leading to prompt treatment avoiding further morbidity and mortality.…”
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    A case of multisystem inflammatory syndrome in an African adolescent male: case report
  9. 2909
    “…Since its introduction into clinical practice, the PAC and the data obtained from its use became paramount in the management of critically ill patients as well as for the high-risk/invasive procedures. …”
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    CON: Pulmonary artery catheter use should be forgone in modern clinical practice
  10. 2910
    por da Silva, Marcelo Santos
    Publicado 2021
    “…Several studies have shown that trypanosomatids depend on DSBs to perform several events of paramount importance during their life cycle. For Trypanosoma brucei, DSBs formation is associated with host immune evasion via antigenic variation. …”
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    DNA Double-Strand Breaks: A Double-Edged Sword for Trypanosomatids
  11. 2911
    “…The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is a multiprotein complex involved in the release of mature interleukin-1β and triggering of pyroptosis, which is of paramount importance in a variety of physiological and pathological conditions. …”
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    An update on the regulatory mechanisms of NLRP3 inflammasome activation
  12. 2912
    “…Paying attention to the neurological aspects of psychiatric manifestations and increasing the awareness of dentists about how to deal with and act on the potential dangers of prion transfer is of paramount importance.…”
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    Creutzfeldt-Jakob Disease after Dental Procedure along with the Initial Manifestations of Psychiatric Disorder: A Case Report
  13. 2913
    “…Deciphering the regulation of the angiotensin-converting enzyme 2 (ACE2), the receptor for SARS-CoV-2, is paramount for understanding the cell tropism of SARS-CoV-2 infection. …”
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    JAK inhibitors dampen activation of interferon-stimulated transcription of ACE2 isoforms in human airway epithelial cells
  14. 2914
    “…Thus, the development of cellular models recapitulating totipotent-like features is of paramount importance. Cells resembling the totipotent cells of early embryos arise spontaneously in mouse embryonic stem (ES) cell cultures. …”
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    Retinoic acid signaling is critical during the totipotency window in early mammalian development
  15. 2915
    “…Tumor recurrence must be kept in mind and a follow-up after apparent complete remission is of paramount importance.…”
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    Renal Epithelioid Angiomyolipoma in Children
  16. 2916
    “…Real world evidence (RWE) and real-world data (RWD) are drawing ever-increasing attention in the pharmaceutical industry and drug regulatory authorities (DRAs) all over the world due to their paramount role in supporting drug development and regulatory decision making. …”
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    Integrating Real-World Evidence in the Regulatory Decision-Making Process: A Systematic Analysis of Experiences in the US, EU, and China Using a Logic Model
  17. 2917
    “…Survival instinct, coping mechanisms and a strong urge to maintain general functionality are of paramount importance intertwined with patients’ ability to cope with the disease and treatment, and their satisfaction with care.…”
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    Experiences of cancer rehabilitation among patients in rural areas in northern Iceland: physical and psychosocial well-being, coping, quality of life, and satisfaction with care. A qualitative study
  18. 2918
    “…A healthy lifestyle and a balanced diet play a paramount role in promoting and maintaining homeostatic functions and preventing an array of chronic and debilitating diseases. …”
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    Diet and Nutrition in Gynecological Disorders: A Focus on Clinical Studies
  19. 2919
    “…Treatment of borderline developmental dysplastic hip is currently a subject of controversy. It is paramount to understand the underlining problem of the individual hip and distinguish instability (dysplasia) from FAI, as the appropriate treatment for unstable hips is periacetabular osteotomy (PAO) and for FAI arthroscopic impingement surgery. …”
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    Complications of hip preserving surgery
  20. 2920
    “…Knowledge about the long-term response of High Mountain Asian glaciers to climatic variations is paramount because of their important role in sustaining Asian river flow. …”
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    High Mountain Asian glacier response to climate revealed by multi-temporal satellite observations since the 1960s
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