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  1. 2941
    “…The progenitor cells among the heterogeneous population in the adipose tissue are of paramount importance as they determine the capacity of regeneration of these tissues. …”
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    Translational products of adipose tissue-derived mesenchymal stem cells: Bench to bedside applications
  2. 2942
    “…Thus, a comprehensive understanding of the different mechanisms responsible for this type of pain is paramount. In this work, we study the tearing of porcine skin in front of an infrared camera, and show that mechanical injuries in biological tissues can generate enough heat to stimulate the neural network. …”
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    Heat Emitting Damage in Skin: A Thermal Pathway for Mechanical Algesia
  3. 2943
    “…The fidelity of start codon recognition by ribosomes is paramount during protein synthesis. The current knowledge of eukaryotic translation initiation implies unidirectional 5ʹ→3ʹ migration of the pre-initiation complex (PIC) along the 5ʹ UTR. …”
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    Bi-directional ribosome scanning controls the stringency of start codon selection
  4. 2944
    “…However, drug resistance is still a major ongoing problem and its investigation is of paramount interest. Here, a high-resolution magic angle spinning (HR-MAS) NMR study is presented deciphering the metabolic profile of non-small cell lung cancer (NSCLC) cells and metabolic adaptations at different levels of induced cisPt-resistance, as well as in their de-induced counterparts (cells cultivated in absence of cisPt). …”
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    (1)H HR-MAS NMR Based Metabolic Profiling of Lung Cancer Cells with Induced and De-Induced Cisplatin Resistance to Reveal Metabolic Resistance Adaptations
  5. 2945
    “…AIM: Sterilization of impression materials is of paramount importance. The present study was conducted to compare the effect of different disinfectants on dimensional accuracy of elastomeric impression materials used for implant prosthesis and other routine treatments. …”
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    Assessment of Effect of Different Sterilization Agents on Dimensional Accuracy of Different Impression Materials in Implant Prosthesis – An In vitro Study
  6. 2946
    “…The initial colonization of the human microbiota is of paramount importance. In this context, the oropharyngeal administration of colostrum is a safe, viable, and well-tolerated practice even by the smallest preterm infants. …”
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    Impact of Oropharyngeal Administration of Colostrum in Preterm Newborns’ Oral Microbiome
  7. 2947
    “…Cell segmentation is crucial to the field of cell biology, as the accurate extraction of single-cell morphology, migration, and ultimately behavior from time-lapse live cell imagery are of paramount importance to elucidate and understand basic cellular processes. …”
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    Robust optical flow algorithm for general single cell segmentation
  8. 2948
    “…Yet, growing evidence suggests that an adequate sampling of physiological responses across a representative taxonomic scope is of paramount importance. This is particularly relevant for Nuclear Receptors (NR), a family of transcription factors, often triggered by ligands and thus, commonly exploited by environmental chemicals. …”
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    From Extrapolation to Precision Chemical Hazard Assessment: The Ecdysone Receptor Case Study
  9. 2949
    “…When designing medicines for children, the ability to fine-tune the dosage while ensuring the safety of the ingredients is of paramount importance. For these purposes solid formulations may represent a valid alternative to liquid formulations for their simpler formula and more stability, and, to overcome the problem of swelling ability, mini-tablets could be a practicable option. …”
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    Mini-Tablets: A Valid Strategy to Combine Efficacy and Safety in Pediatrics
  10. 2950
    “…Deep understanding of the SARS-CoV-2 effects on host molecular pathways is paramount for the discovery of early biomarkers of outcome of coronavirus disease 2019 (COVID-19) and the identification of novel therapeutic targets. …”
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    Metabolic and Immune Markers for Precise Monitoring of COVID-19 Severity and Treatment
  11. 2951
    “…[Image: see text] Pancreatic ductal adenocarcinoma (PDAC), as one of the most malignant tumors with dense desmoplastic stroma, forms a specific matrix barrier to hinder effective diagnosis and therapy. To date, a paramount challenge is in the search for intelligent nanotheranostics for such hypopermeable tumors, especially in breaking the PDAC-specific physical barrier. …”
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    Sequence-Activated Fluorescent Nanotheranostics for Real-Time Profiling Pancreatic Cancer
  12. 2952
    “…To reduce this risk, providing food safety awareness programs to this portion of the population is paramount.…”
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    Knowledge, Practices, and Risk Perception Associated with Foodborne Illnesses among Females Living in Dubai, United Arab Emirates
  13. 2953
    “…Although preoperative histological diagnosis is difficult, it has paramount value in therapeutic strategy development and prognostic estimation. …”
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    Percutaneous intravenous catheter forceps biopsy in right atrial mass: two case reports and literature review
  14. 2954
    por Karasik, Jaclyn
    Publicado 2022
    “…However, even when we were able to elicit a response from prospective participants, follow-up has remained a substantial challenge. CONCLUSIONS: It is paramount for public health practitioners to employ creative strategies and to invest time and resources to include hard-to-reach communities in research.…”
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    Door-to-door recruitment during the COVID-19 pandemic: Lessons learned from a population-based, longitudinal cohort study in North Carolina, USA
  15. 2955
    “…Yet, under the current climatic crisis, assessing the effects of water contaminants and temperature is paramount to understanding the biological impacts of mixtures of stressors on aquatic ecosystems. …”
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    Prioritizing the Effects of Emerging Contaminants on Estuarine Production under Global Warming Scenarios
  16. 2956
    “…Coding is generally of paramount importance to chemistry students regardless of whether they intend to work with theoretical chemistry. …”
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    Google Colab and Virtual Simulations: Practical e-Learning Tools to Support the Teaching of Thermodynamics and to Introduce Coding to Students
  17. 2957
    “…Standardizing methods of blood pressure assessment, effectiveness measures beyond blood pressure alone, and safety outcomes are paramount. The Hypertension Academic Research Consortium (HARC) document represents an integration of evolving evidence and consensus opinion among leading experts in cardiovascular medicine and hypertension research with regulatory perspectives on clinical trial design and methodology. …”
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    Clinical Trial Design Principles and Outcomes Definitions for Device-Based Therapies for Hypertension: A Consensus Document From the Hypertension Academic Research Consortium
  18. 2958
    “…The prevention of cardiovascular disease remains paramount, and this review provides a roadmap for instituting appropriate therapies in cardiovascular disease prevention.…”
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    Contemporary Management of Dyslipidemia
  19. 2959
    “…It advocates for a renewed focus and support for young people’s skills as  paramount for effective humanitarian response and building back resilient communities after emergencies. …”
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    Engaging local youths in humanitarian response is not a matter of if but how
  20. 2960
    “…In this review, we highlight the paramount importance of beneficial strains of microorganisms, macro, and microalgae in the bioeconomy. …”
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    Application of biological systems and processes employing microbes and algae to Reduce, Recycle, Reuse (3Rs) for the sustainability of circular bioeconomy
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