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  1. 3321
    “…With the exponential increase in new cases coupled with an increased mortality rate, cancer has ranked as the second most prevalent cause of death in the world. Early detection is paramount for suitable diagnosis and effective treatment of different kinds of cancers, but this is limited to the accuracy and sensitivity of available diagnostic imaging methods. …”
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    Applications of Computational Methods in Biomedical Breast Cancer Imaging Diagnostics: A Review
  2. 3322
    “…In the current context of climate change, determining which factors better constrain their variation within lake districts become of paramount importance for understanding species distribution and their conservation. …”
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    Factors of surface thermal variation in high-mountain lakes of the Pyrenees
  3. 3323
    “…Imaging modalities, in particular a head MRI is paramount while contemplating the differential diagnosis of a solid and cystic intracranial lesions, owing to its high sensitivity and specificity. …”
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    Importance of MRI in the diagnosis of a rare intracranial mucocele associated with frontal paranasal osteoma: Case report and literature review
  4. 3324
    “…An understanding of the immune mechanisms that lead to rejection versus tolerance of allogeneic pancreatic islet grafts is of paramount importance, as it facilitates the development of innovative methods to improve the transplant outcome. …”
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    Integrated Metabolomics and Proteomics Analyses in the Local Milieu of Islet Allografts in Rejection versus Tolerance
  5. 3325
    “…Given the economic value of ajowan and its increasing demand across the globe, the extraction method used for its EO is of paramount importance in terms of quality and quantity of the final product. …”
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    A Design of Experiment (DoE) Approach to Model the Yield and Chemical Composition of Ajowan (Trachyspermum ammi L.) Essential Oil Obtained by Microwave-Assisted Extraction
  6. 3326
    “…Preserving the humanistic aspects of care is of paramount importance.…”
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    Cancer Treatment During COVID-19: A Qualitative Analysis of Patient-Perceived Risks and Experiences with Virtual Care
  7. 3327
    “…The recent emergence of multiple SARS-CoV-2 variants has caused considerable concern due to reduced vaccine efficacy and escape from neutralizing antibody therapeutics. It is therefore paramount to develop therapeutic strategies that inhibit all known and future SARS-CoV-2 variants. …”
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    Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variants
  8. 3328
    por Sheikh, Saulat S., Locke, Jayme E.
    Publicado 2021
    “…PURPOSE OF REVIEW: Transplantation is the life-saving therapy for patients suffering from end-organ failure, and as such, equitable access to transplantation (ATT) is of paramount importance. Unfortunately, gender/sex-based disparities exist, and despite the transplant community's awareness of this injustice, gender/sex-based disparities have persisted for more than two decades. …”
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    Gender disparities in transplantation
  9. 3329
    “…Monitoring the burden and spread of infection with the new coronavirus SARS-CoV-2, whether within small communities or in large geographical settings, is of paramount importance for public health purposes. Serology, which detects the host antibody response to the infection, is the most appropriate tool for this task, since virus-derived markers are most reliably detected during the acute phase of infection. …”
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    Highly versatile antibody binding assay for the detection of SARS-CoV-2 infection and vaccination
  10. 3330
    “…The signals were processed by the microcontroller and then wirelessly transmitted to the intelligent car for remote telemetry and control. This work is of paramount potential for the application of various terminal devices in self-powered HMI systems with high integration for wearable electronics.…”
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    All-in-One Self-Powered Human–Machine Interaction System for Wireless Remote Telemetry and Control of Intelligent Cars
  11. 3331
    “…The hydrophilicity of the fiber mesh is of paramount importance, as it promotes cell spreading; however, the most commonly used polyvinyl alcohol (PVA) and other hydrophilic fiber meshes immediately disintegrate in aqueous media. …”
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    The Effect of the PVA/Chitosan/Citric Acid Ratio on the Hydrophilicity of Electrospun Nanofiber Meshes
  12. 3332
    “…Early recognition and prompt treatment are of paramount importance. To obtain good results in the revision surgery of failed multiligamentary knee reconstructions, it is crucial to perform a thorough and exhaustive evaluation to detect all the causes of failure. …”
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    Complications of surgical reconstruction of multiligament injuries of the knee joint: diagnosis, prevention and treatment
  13. 3333
    “…DISCUSSION: This case demonstrates the paramount importance of early diagnosis and treatment for patients with CP. …”
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    A case report of tuberculous constrictive pericarditis necessitating total pericardiectomy
  14. 3334
    “…Affordable and scalable tools to monitor the transmission dynamics of the SARS-CoV-2 virus and the longevity of induced antibodies will be paramount to monitor and control the pandemic as multiple waves continue to rage in many countries. …”
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    Performance Evaluation of Lateral Flow Assays for Coronavirus Disease-19 Serology
  15. 3335
    “…With Liver diseases becoming more prevalent in society, the need to implement these techniques to utilize liver MRI to its full potential, is paramount. In this review, we report on the current methods and applications of AI methods in liver MRI, with a focus on machine learning and deep learning methods. …”
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    Emerging artificial intelligence applications in liver magnetic resonance imaging
  16. 3336
    “…CONCLUSION: Although an SSC is a rare variation of nasal air cells, preoperative diagnosis of this cell is of paramount importance in some patients during endoscopic transnasal surgery for the identification of skull base.…”
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    How important is the Sphenoseptal cell in identifying the skull base?Recent incidence and demonstration of endoscopic surgical steps
  17. 3337
    “…The Assessment of Activities of Daily Living (ADL) is paramount to ensure the accurate early diagnosis of neurocognitive disorders. …”
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    The Usefulness of Evaluating Performance of Activities in Daily Living in the Diagnosis of Mild Cognitive Disorders
  18. 3338
    “…The Toll‐like receptor 4 (TLR4)/myeloid differentiation factor 2 (MD‐2) innate immunity system is a membrane receptor of paramount importance as therapeutic target. Its assembly, upon binding of Gram‐negative bacteria lipopolysaccharide (LPS), and also dependent on the membrane composition, finally triggers the immune response cascade. …”
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    Full‐Atom Model of the Agonist LPS‐Bound Toll‐like Receptor 4 Dimer in a Membrane Environment
  19. 3339
    “…The condition is associated with high morbidity and mortality, and the role of early diagnosis and reporting to prevent complications is paramount. The recurrent pneumonia observed in the patient also raises questions related to long-term antibiotic use and immunization in the case of polysplenia in this patient population.…”
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    A Rare Case of Recurrent Pneumonia in Heterotaxy Syndrome, Polysplenia/Left Isomerism
  20. 3340
    por Pogostin, Brett H., McHugh, Kevin J.
    Publicado 2021
    “…During the current COVID-19 pandemic, recent advances in mRNA engineering have proven paramount in the rapid design and production of effective vaccines. …”
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    Novel Vaccine Adjuvants as Key Tools for Improving Pandemic Preparedness
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