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  1. 3581
    “…In these attempts, the in vivo preclinical studies are of paramount importance; therefore, serious analysis is required to choose the right murine OI model able to emulate as closely as possible the disease of the target OI population. …”
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  2. 3582
    “…Sophisticated cyber-attacks may take advantage the increased interconnectedness or other security gaps of an ICS and infiltrate the system with devastating consequences to the economy, national security, and even human life. Due to the paramount importance of detecting and isolating these attacks, we propose an unsupervised anomaly detection approach that employs causal inference to construct a robust anomaly score in two phases. …”
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  3. 3583
    “…Overall, this study identified many important alterations in the proteome of th(3/+) mice, amongst which mitochondrial defects leading to skeletal muscle remodelling and metabolic dysfunction were paramount.…”
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  4. 3584
    “…Conclusion High professionalism standards are justified in a profession where patient trust is paramount. However, a problem lies in the culture that surrounds professionalism in terms of litigation and dental professionals feel pressure to possess an unattainable, infallible nature. …”
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  5. 3585
    “…Exploring durable electrocatalysts with high activity for oxygen evolution reaction (OER) in acidic media is of paramount importance for H(2) production via polymer electrolyte membrane electrolyzers, yet it remains urgently challenging. …”
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  6. 3586
  7. 3587
    “…Bacteriophages (phages) are well-documented to carry HEGs, with the paramount characterization of HEGs being focused on those encoded by coliphage T4. …”
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  8. 3588
    “…Recent single-cell analyses have systematically identified neuronal diversity at unprecedented scale and speed, leaving the deconstruction of spatiotemporal mechanisms for generating neuronal diversity an imperative and paramount challenge. In this review, we highlight three distinct strategies deployed by neural progenitors to produce diverse neuronal subtypes, including predetermined, stochastic, and cascade diversifying models, and elaborate how these strategies are implemented in distinct regions such as the neocortex, spinal cord, retina, and hypothalamus. …”
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  9. 3589
    “…Sepsis and septic shock are medical emergencies and time-dependent diseases with a high mortality rate for which early identification, early antibiotic therapy, and early source control are paramount for patient outcomes. The patient may require surgical intervention or an invasive procedure aiming to control the source of infection, and the anesthesiologist has a pivotal role in all phases of patient management. …”
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  10. 3590
    “…KEY ISSUES: Globally, public health care is complex and evolving and effective nursing leadership is paramount to meet public health needs and support health care systems. …”
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  11. 3591
  12. 3592
    “…That flies evolved an ability to actuate their retinas argues that moving the eye independently of the head is broadly paramount for animals. The similarities of smooth and saccadic movements of the Drosophila retina and the vertebrate eye highlights a notable example of convergent evolution.…”
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  13. 3593
    “…Developing a timely and effective response to emerging SARS-CoV-2 variants of concern (VOCs) is of paramount public health importance. Global health surveillance does not rely on genomic data alone to identify concerning variants when they emerge. …”
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  14. 3594
    “…For instance, cruzain of protozoan parasite Trypanosoma cruzi is responsible for the Chagas disease, while the role of human cathepsin L is associated with some cancers or is a potential target for the treatment of COVID-19. However, despite paramount work carried out during the past years, the compounds that have been proposed so far show limited inhibitory action against these enzymes. …”
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  15. 3595
    “…In order to advance desulfurization technology, a new method for excellent oxidative desulfurization of fuel at room temperature will be of paramount importance. As a novel desulfurization method, we developed piezo-catalysts that do not require adding any oxidants and can be performed at room temperature. …”
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  16. 3596
    “…Aging theories that consider individual aging trajectories are of paramount importance to meet the WHO’s aim. Both the revised Scaffolding Theory of Aging and Cognition (STAC-r) and Cognitive Reserve theory (CR) offer theoretical frameworks for the mechanisms of cognitive aging and the positive influence of an engaged lifestyle. …”
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  17. 3597
    “…Up to 50% of children with VUR may develop reflux nephropathy (RN), and the diagnosis and monitoring of renal scars are invasive and costly procedures, so it is paramount to find a non-invasive and accurate method to predict the risk of renal damage. …”
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  18. 3598
    “…By helping to align healthcare providers’ interventions with what matters most to the patient, PROs contribute to the individualized choice of Anti-Retroviral Therapy (Carfora et al. in PLoS ONE 17(4): e0267030, https://doi.org/10.1371/journal.pone.0267030, 2022) as a paramount component of tailored and person-centred care management, in routine clinical practice. …”
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  19. 3599
    “…Moreover, the pandemic is not over yet and is transitioning to becoming an epidemic in recent years; hence, monitoring liver function tests (LFTs) and assessing hepatic consequences of COVID-19 in patients with or without liver illnesses would be of paramount interest. This pragmatic review explores the correlations between COVID-19 and liver disease severity based on abnormal liver biochemistries and other possible mechanisms in individuals of all ages from the emergence of the COVID-19 pandemic to the post-pandemic period. …”
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  20. 3600
    “…The current consensus is that ERT initiation during early childhood is paramount. Nonetheless, complete recovery of organs in patients with advanced FD is challenging. …”
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