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  1. 3881
    “…As such, maintenance of cardiac homeostasis is paramount for its physiological function and its capacity to respond to environmental stimuli. …”
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    Epitranscriptomics of cardiovascular diseases (Review)
  2. 3882
    “…Antimicrobial resistance has emerged as a global health crisis and, therefore, new drug discovery is a paramount need. Cannabis sativa contains hundreds of chemical constituents produced by secondary metabolism, exerting outstanding antimicrobial, antiviral, and therapeutic properties. …”
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    Antimicrobial and Antiviral (SARS-CoV-2) Potential of Cannabinoids and Cannabis sativa: A Comprehensive Review
  3. 3883
    “…Therefore, further studies are paramount in establishing its efficacy in clinical settings. …”
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    Emerging roles of cardamonin, a multitargeted nutraceutical in the prevention and treatment of chronic diseases
  4. 3884
    “…Therefore, the identification of easy and accessible EV isolation techniques with a low price/performance ratio is of paramount importance. We isolated EVs from a wide spectrum of samples of biological and clinical interest by choosing two isolation techniques, based on their wide use and affordability: ultracentrifugation and salting-out. …”
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    Salting-Out Approach Is Worthy of Comparison with Ultracentrifugation for Extracellular Vesicle Isolation from Tumor and Healthy Models
  5. 3885
    “…With the proliferation of Unmanned Aerial Vehicles (UAVs) to provide diverse critical services, such as surveillance, disaster management, and medicine delivery, the accurate detection of these small devices and the efficient classification of their flight modes are of paramount importance to guarantee their safe operation in our sky. …”
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    RF Signal-Based UAV Detection and Mode Classification: A Joint Feature Engineering Generator and Multi-Channel Deep Neural Network Approach
  6. 3886
    “…The paramount importance of a healthy diet in the prevention of type 2 diabetes is now well recognized. …”
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    Blueberry Counteracts Prediabetes in a Hypercaloric Diet-Induced Rat Model and Rescues Hepatic Mitochondrial Bioenergetics
  7. 3887
    “…Rheumatoid arthritis (RA) is characterized by the presence of autoantibodies that are of paramount importance for the diagnosis and prognosis of the disease and have been implicated in its pathogenesis. …”
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    Peptides Bearing Multiple Post-Translational Modifications as Antigenic Targets for Severe Rheumatoid Arthritis Patients
  8. 3888
    “…We argue that this aspect of brain function is of paramount importance for systems neuroscience, as it confers neural specialization and allows animals to attain far more sophisticated behaviours than would be possible through genetic mechanisms alone. …”
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    Self-tuition as an essential design feature of the brain
  9. 3889
    “…Once identified, protecting these groups through transmission and mortality risk reduction will become paramount. As the pandemic progresses, “protecting the vulnerable” may enable a return to normal for the majority, whilst still protecting individuals living with and beyond cancer who already live with the challenges of having a cancer diagnosis.…”
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    As COVID-19 cases surge despite mass vaccination, it’s time to focus on the vulnerable
  10. 3890
    “…The subcellular localization of IDE, a paramount aspect to understand how this enzyme can perform its proteolytic functions in vivo, remains highly controversial. …”
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    Evolutionary Origin of Insulin-Degrading Enzyme and Its Subcellular Localization and Secretion Mechanism: A Study in Microglial Cells
  11. 3891
    “…Given that discussions around racism are silenced, it is paramount to create space where racism can be safely discussed and to develop a safe healthcare environment for the benefit of staff and patients.…”
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    “Just Throw It Behind You and Just Keep Going”: Emotional Labor when Ethnic Minority Healthcare Staff Encounter Racism in Healthcare
  12. 3892
    “…In lung cancer accurate assessment of the mediastinal lymph node status is of paramount importance for the stage assignment as well as crucial for the therapeutic plan. …”
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    The role of sonographic patterns during endobronchial ultrasound-transbronchial needle aspiration for lung cancer staging: a narrative review
  13. 3893
    “…The ORN treatment still represents a great challenge; therefore, the prevention is of paramount importance. Thus, the present study aimed to evaluate retrospectively a perioperative systemic antibiotic therapy protocol for the prevention of ORN following tooth extraction in head-and-neck patients post-3D conformal RT. …”
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    Antibiotic therapy for the prevention of osteoradionecrosis following tooth extraction in head-and-neck cancer patients postradiotherapy: An 11-year retrospective study
  14. 3894
    “…As patient care shifts toward home-based settings, the role of the pharmacist is paramount in providing a continuation of care and acting as the bridge between patient and clinic. …”
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    Expanding the Role of the Pharmacist: Immunoglobulin Therapy and Disease Management in Neuromuscular Disorders
  15. 3895
    “…Understanding the disease-promoting mechanisms of environmental toxicants related to endometriosis and adenomyosis is paramount to designing more effective treatment(s) and preventative strategies.…”
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    The Potential Relationship Between Environmental Endocrine Disruptor Exposure and the Development of Endometriosis and Adenomyosis
  16. 3896
    “…Promoting a more positive incentive culture for all ecosystem members is also paramount. In this commentary, we—the Local Network Leads of the UK Reproducibility Network—outline our response to the UK House of Commons Science and Technology Committee’s inquiry on research integrity and reproducibility. …”
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    Reforms to improve reproducibility and quality must be coordinated across the research ecosystem: the view from the UKRN Local Network Leads
  17. 3897
    por Alsaawy, Saad Mohammed
    Publicado 2022
    “…Careful preoperative surgical planning and decision about the neoadjuvant treatment are paramount.We report a 40-year-old male newly diagnosed with rectal adenocarcinoma with ectopic kidney. …”
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    Locally advanced rectal cancer in a patient with ectopic kidney: case report and literature review
  18. 3898
    “…The factors that determine why ecosystems exhibit abrupt shifts in state are of paramount importance for management, conservation, and restoration efforts. …”
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    Kelp-forest dynamics controlled by substrate complexity
  19. 3899
    “…The PI3K/AKT pathway, negatively regulated by PTEN, plays a paramount role in glucose metabolism regulation due to its activation by the insulin receptor signaling pathway. …”
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    PTEN Deletion in Adult Mice Induces Hypoinsulinemia With Concomitant Low Glucose Levels
  20. 3900
    “…This method may become the next standard procedure, particularly in some cases where histological evaluation is paramount, and conventional biopsy methods are not suitable.…”
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    A preliminary study of the diagnostic efficacy and safety of the novel boring biopsy for brain lesions
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