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  1. 3961
  2. 3962
    “…l-lactate is a catabolite from the anaerobic metabolism of glucose, which plays a paramount role as a signaling molecule in various steps of the cell survival. …”
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  3. 3963
    “…Such interactions, too many to tally, are of paramount importance for the identification of novel disease biomarkers and more personalized therapeutic intervention. …”
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  4. 3964
  5. 3965
    “…Monitoring of cognitive performance during long-duration space flight therefore is of paramount importance and can be performed using compact state-of-the-art mobile EEG. …”
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  6. 3966
    “…Recognition of the phenomenon is of paramount importance for enhanced insights into the pathophysiological processes of vascular remodeling. …”
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  7. 3967
    “…Visualization aspects further limits the collection of imaged frame contextual details, therefore the utility of computational methods such as tracking of tissue and tools, scene segmentation, and depth estimation are of paramount interest. Here, we discuss an online preprocessing framework that overcomes routinely encountered visualization challenges associated with the MIS. …”
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  8. 3968
    “…In dynamic healthcare environments including the COVID-19 pandemic, it is paramount to communicate health recommendations expediently and clearly. …”
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  9. 3969
    “…While this is a well-known side effect, it is also often overlooked. It is paramount that both physicians and patients know how to correctly manage metamizole to prevent and promptly treat agranulocytosis.…”
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  10. 3970
    “…The detection of oncopathologies in the early stages of development is a paramount task of modern medicine, which can be solved only by improving modern diagnostic methods. …”
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  11. 3971
    por Arnold, Jeffrey
    Publicado 2010
    “…The correctness, speed and accuracy of these computations are of paramount importance. The lack of any of these characteristics can mean the difference between new, exciting physics and an embarrassing correction. …”
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  12. 3972
    por Métral, Elias
    Publicado 2021
    “…For this, an excellent instrumentation is of paramount importance to be able to diagnose if the instability is longitudinal or transverse, single bunch, or coupled bunch, involving only one mode of oscillation or several, and the evolution of the intrabunch motion with intensity is a fundamental observable with high-intensity high-brightness beams. …”
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  13. 3973
    por Guida, R, Mandelli, B
    Publicado 2019
    “…In addition, the reduction of R134a and SF6 emission in the atmosphere from anthropogenic activityis is of paramount importance because GHGs are believed to be at the origin of climate changes. …”
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  14. 3974
    “…With the continuous growth in data volume from Large Hadron Collider (LHC) experiments handling and processing massive datasets become paramount. Efficient data access and transfer across multiple computing centers and institutions are crucial for collaboration. …”
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  15. 3975
    “…The computation of the strain state in the coils during quench then becomes of paramount importance for magnet design, and requires a complete three-dimensional (3-D) analysis of quench phenomena. …”
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  16. 3976
    “…For the cool down of the 18.5 t cold mass within 22 days and for current leads cooling, the use of powerful single stage cryocoolers is of paramount importance. The cooling power is distributed across the cold mass and thermal shield using helium gas flow enforced by cryocirculators. …”
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  17. 3977
  18. 3978
    “…Early diagnosis and appropriate management have paramount importance in reducing mortality and morbidity in these patients.…”
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  19. 3979
    “…Managing Elderly type 2 diabetes (E-T2D) is challenging due to geriatric conditions (e.g., co-morbidity, multiple drug intake, etc.), and personalization becomes paramount for precision medicine. This paper presents a human digital twin (HDT) framework to manage E-T2D that exploits various patient-specific data and builds a suite of models exploiting the data for prediction and management to personalize diabetes treatment in E-T2D patients. …”
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  20. 3980
    “…Homologous recombination (HR), an evolutionary conserved pathway, plays a paramount role(s) in genome plasticity. The pivotal HR step is the strand invasion/exchange of double-stranded DNA by a homologous single-stranded DNA (ssDNA) covered by RAD51. …”
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