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  1. 4201
  2. 4202
    “…Notwithstanding the promising benefits that alpha-synuclein presents to therapeutics and diagnostics development for Parkinson’s disease, finding ways to address potential challenges such as inadequate preclinical models, safety and efficacy will be paramount to achieving clinical translation. In this comprehensive review paper, we described the role of alpha-synuclein in the pathogenesis of Parkinson’s disease, as well as how its structure and function relationship delineate disease onset and progression. …”
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  3. 4203
    “…Although the initial work-up of the patient was inconclusive, our clinical judgment was paramount in managing the patient.…”
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  4. 4204
    “…When chest wall defects are present, a multidisciplinary team, including an orthopedist and thoracic and plastic surgeons, is of paramount importance for optimal surgical management. …”
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  5. 4205
    “…Determination of internal qualities such as total soluble solids (TSS) and pH is a paramount concern in strawberry cultivation. Therefore, the main objective of the current study was to develop a non-destructive approach with machine learning algorithms for predicting TSS and pH of strawberries. …”
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  6. 4206
    “…When the goal is to increase the rotating bending fatigue strength of austenitic chromium-nickel steels, and the requirements for significant wear resistance are not paramount, diamond burnishing (DB) has significant potential to increase the fatigue strength and, based on the cost/quality ratio, can successfully compete with low-temperature chemical-thermal treatments. …”
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  7. 4207
  8. 4208
    por Bardus, Marco, Massoud, May A.
    Publicado 2022
    “…Understanding what motivates citizens to sort waste at home is paramount to designing effective, efficient, and equitable waste management interventions. …”
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  9. 4209
    “…Health and well-being of dogs are of paramount importance to their owners. Digestion plays a key role in dog health, involving physicochemical, mechanical and microbial actors. …”
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  10. 4210
    “…On that account, the ability to effectively detect and classify ligand binding sites in proteins is of paramount importance to modern structure-based drug discovery. …”
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  11. 4211
    “…The identification of the factors underlying the willingness or lack thereof to respond to public health emergencies is paramount to informing more capable health services. …”
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  12. 4212
    “…The possibility to easily and rapidly assess the presence of Gd(3+) ions in solution is of paramount importance in many domains like magnetic resonance imaging. …”
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  13. 4213
    “…But for early detection and development, the establishment of biomarkers are of paramount importance. Contemporary evidence also validates the signature of a set of this epigenetic factor miRNA in the development of various diseases, including T2DM. …”
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  14. 4214
    por Musci, Tatjana, Grubitzsch, Herko
    Publicado 2022
    “…A better understanding of pathogenesis, clinical profile, and outcomes is paramount. Further research on surgical treatment is needed to provide more comprehensive information for defining the most suitable treatment option, finding the optimal time for surgery, and reducing morbidity and mortality.…”
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  15. 4215
    por Fortuna, Miguel A.
    Publicado 2022
    “…Therefore, understanding the extent to which species will cope with rising temperatures is of paramount importance. Phenotypic plasticity is the ability of an organism to change the morphological and functional traits encoded by its genome in response to the environment. …”
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  16. 4216
    por Tort Herrando, V.
    Publicado 2021
    “…From forensic psychiatry, this topic have a special relevance as they have more serious consequences (to avoid prison, child custody, etc)(Resnick 2003, Gunn 2014). Another topic of paramount importance is that in psychiatry we have not complementary examinations (RMN, TAC, blood tests, etc) that help to discard some symptoms. …”
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  17. 4217
    “…Adequate patient selection, precise electric leads placement, and correct DBS programming are paramount for good surgical outcomes. Nonetheless, DBS still has many limitations: axial symptoms and signs, such as speech, balance and gait, do not improve to the same extent as appendicular symptoms and can even be worsened as a direct or indirect consequence of surgery and stimulation. …”
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  18. 4218
    “…Large size studies are paramount to further explore the effectiveness of POCUS and identify key challenges to its implementation.…”
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  19. 4219
    “…Though, vulnerable populations (e.g., older and less educated participants) mainly rely on traditional media, stressing the need for continued support. Thus, it is paramount to increasingly use mixed methods designs and concurrently examine multiple channels to reflect real-world warning practices and generate ecologically valid results.…”
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  20. 4220
    “…More noninvasive, inexpensive, and safer diagnostic methods based on novel biomarkers for NSCLC are of paramount importance. In the current review, we summarize genomic and proteomic biomarkers utilized for the early detection and treatment of NSCLC. …”
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