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  1. 4501
    “…However, Ras mutations alone are insufficient for tumorigenesis, therefore it is paramount to identify cooperating cancer-relevant signaling pathways. …”
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    A genome-wide Drosophila epithelial tumorigenesis screen identifies Tetraspanin 29Fb as an evolutionarily conserved suppressor of Ras-driven cancer
  2. 4502
    “…Nerve fascicles preservation technique is paramount to the functional preservation of the trigeminal nerve. …”
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    Presigmoid Approach to Dumbbell Trigeminal Schwannoma
  3. 4503
    “…Determining whether the structural and functional stress responses of communities are similar across space and time is paramount for forecasting and extrapolating the consequences of anthropogenic pressures on ecosystems and their services. …”
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    Similar recovery time of microbial functions from fungicide stress across biogeographical regions
  4. 4504
    “…This is especially useful in case of a precise quantification of agonist efficacies, and is of paramount importance, when determining agonist bias in relation to the β-arrestin pathway. …”
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    A split luciferase-based probe for quantitative proximal determination of Gα(q) signalling in live cells
  5. 4505
    “…We conclude that advancing knowledge concerning the origin and maintenance of specific tinnitus subtypes origin and maintenance mechanisms is of paramount importance for identifying adequate treatment.…”
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    Pathophysiology of Subjective Tinnitus: Triggers and Maintenance
  6. 4506
    “…Therefore, it is of paramount importance to explore predictive markers for bone metastasis of PCa. …”
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    Downregulation of miR-505-3p predicts poor bone metastasis-free survival in prostate cancer
  7. 4507
    “…In mechanical ventilation, it is paramount to ensure the patient’s ventilatory demand is met while minimizing asynchronies. …”
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    Predicting Patient-ventilator Asynchronies with Hidden Markov Models
  8. 4508
    “…CONTEXT: Early detection of oral cancer is of paramount importance in determining the prognosis of oral cancer. …”
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    Comparative efficacy of chemiluminescence and toluidine blue in the detection of potentially malignant and malignant disorders of the oral cavity
  9. 4509
    “…Therefore, assessing the proportion of preterm birth and associated factors among Mothers who gave Birth in Debretabor town health institutions have a paramount importance in designing an effective strategy to intervene. …”
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    Proportion of Preterm birth and associated factors among mothers who gave birth in Debretabor town health institutions, northwest, Ethiopia
  10. 4510
    por Song, Yang, Wang, Yan, Guo, Dandan, Jing, Lan
    Publicado 2019
    “…Thus, the identification of reference genes with stable expression during different conditions is of paramount importance. Here, we present a study where in vitro and in planta experiments were used to validate the expression stability of reference gene candidates of Puccinia helianthi Schw., an obligate pathogen that causes rust in sunflower (Helianthus annuus). …”
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    Selection of reference genes for quantitative real-time PCR normalization in the plant pathogen Puccinia helianthi Schw.
  11. 4511
    “…BACKGROUND: Alternative techniques for nasal dorsum augmentation are of paramount importance in reconstructive and plastic surgery. …”
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    In vivo evaluation of a regenerative approach to nasal dorsum augmentation with a polycaprolactone-based implant
  12. 4512
    “…Optimal glycaemic control pre-conception and throughout pregnancy is paramount to achieve the best outcomes and to minimise the risk of complications for the mother and baby. …”
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    Successful Outcomes with Insulin Degludec in Pregnancy: A Case Series
  13. 4513
    “…In real life scenarios, we are exposed to mixtures of chemicals rather than single chemicals, and it is therefore of paramount importance to assess their toxicity. In this study, we investigated the toxicity of Cd and Pb alone and as a mixture in an animal model of acute exposure. …”
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    Toxic Effect of Acute Cadmium and Lead Exposure in Rat Blood, Liver, and Kidney
  14. 4514
    “…Therefore, assessing the ecological significance of R:FR‐mediated defence is paramount to better understand the evolution of this physiological linkage and its implications for crop breeding.…”
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    Ecological significance of light quality in optimizing plant defence
  15. 4515
    “…Numerous tools exist to deduce aberrations from massive parallel sequencing data, yet most are optimized for research and often fail to redeem paramount needs in a clinical setting. Optimally, a read depth-based analytical software should be able to deal with single-end and low-coverage data—this to make sequencing costs feasible. …”
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    WisecondorX: improved copy number detection for routine shallow whole-genome sequencing
  16. 4516
    “…With an ageing world population, preservation of older adults’ health and quality of life (QoL) is paramount. Due to lower levels of physical functionality, older adults are particularly susceptible to local environment influences, especially those living alone and lacking family support. …”
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    Objectively-Measured Neighbourhood Attributes as Correlates and Moderators of Quality of Life in Older Adults with Different Living Arrangements: The ALECS Cross-Sectional Study
  17. 4517
    “…Since mortality from AAS is high, a prompt and accurate diagnosis using imaging techniques is paramount. Both transthoracic (TTE) and transoesophageal echocardiography (TEE) are useful in the diagnosis of AAS. …”
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    The current role of echocardiography in acute aortic syndrome
  18. 4518
    por Hunzeker, Adam, Amin, Rohul
    Publicado 2016
    “…To avoid diagnostic pitfalls, it is paramount to employ carefully constructed diagnostic cognitive processes. …”
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    Teaching Cognitive Bias in a Hurry: Single-Session Workshop Approach for Psychiatry Residents and Students
  19. 4519
    “…A thorough medical history, including types of food consumed, is paramount and can often suggest differential diagnosis. …”
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    A blind passenger: a rare case of documented seroconversion in an Angiostrongylus cantonensis induced eosinophilic meningitis in a traveler visiting friends and relatives
  20. 4520
    “…The Cre‐LoxP system gene knockout (KO) technology provides cell‐ and time‐specificity of gene ablation to investigate cell‐autonomous gene function in vivo, and is paramount for understanding the function of genes involved in bone development, remodeling, and repair. …”
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    Promoter Cre‐Specific Genotyping Assays for Authentication of Cre‐Driver Mouse Lines
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