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  1. 4581
    “…Cell polarization is of paramount importance for proliferation, differentiation, development, and it is altered during carcinogenesis. …”
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    Haspin regulates Ras localization to promote Cdc24-driven mitotic depolarization
  2. 4582
    “…Identification of glycan functional epitopes is of paramount importance for rational design of glycoconjugate vaccines. …”
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    Structure‐Guided Design of a Group B Streptococcus Type III Synthetic Glycan–Conjugate Vaccine
  3. 4583
    “…On the face of ongoing death and destruction, the urgent need for the discovery of a vaccine against the virus is paramount. This study resorted to the emerging discipline of immunoinformatics in order to design a multi-epitope mRNA vaccine against the spike glycoprotein of SARS-CoV-2. …”
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    Designing a novel mRNA vaccine against SARS-CoV-2: An immunoinformatics approach
  4. 4584
    por Du, Baixue, He, Xin, Wang, Yujiao, He, Weimin
    Publicado 2020
    “…As a clinical characteristic, the lesions have a high risk of local recurrence; therefore, aggressive resection and careful postoperative follow-up are paramount.…”
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    Multiple recurrent myxofibrosarcoma of the orbit: case report and review of the literature
  5. 4585
    “…The information reviewed here constitutes a paramount intellectual basis to sustenance ongoing research to tackle the SARS-CoV-2 issue. …”
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    Water matrices as potential source of SARS-CoV-2 transmission – An overview from environmental perspective
  6. 4586
    “…Combining phenotypic and genetic characteristics in a genetic variation study is of paramount importance to effectively orient the selection of producers’ elite trees in a seed orchard. …”
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    Phenotypic Variability and Genetic Diversity in a Pinus koraiensis Clonal Trial in Northeastern China
  7. 4587
    “…Despite the general agreement that individualizing treatment goals and avoiding hypoglycaemia is paramount for the therapy of older people with diabetes, there are conflicting perspectives on specific glycaemic targets that should be adopted and on use of specific drugs and treatment strategies. …”
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    Evaluating glucose‐lowering treatment in older people with diabetes: Lessons from the IMPERIUM trial
  8. 4588
    “…It is paramount to expand the knowledge base and minimize the consequences of the pandemic caused by the new Coronavirus (SARS-Cov2). …”
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    The effect of lockdown on the outcomes of COVID-19 in Spain: An ecological study
  9. 4589
    “…T-cell-mediated cellular immunity was thought to be of paramount importance against MDV. However, MDV also infects macrophages, B cells and T cells, leading to immunosuppression and T-cell lymphoma. …”
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    Revisiting cellular immune response to oncogenic Marek’s disease virus: the rising of avian T-cell immunity
  10. 4590
    “…RESULTS AND CONCLUSIONS: Because of the high incidence of recurrence in CD, annual clinical and biochemical follow-up is paramount. 50% of recurrences occur during the first 50 months after first surgery. …”
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    Recurrence after pituitary surgery in adult Cushing’s disease: a systematic review on diagnosis and treatment
  11. 4591
    “…In order to combat these challenges and devise appropriate therapeutic strategies, it becomes of paramount importance to elucidate the pathophysiology of this illness. …”
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    COVID-19-Associated Coagulopathy: An Exacerbated Immunothrombosis Response
  12. 4592
    “…To ensure an optimal match between the characteristics of the patient and the properties of the chosen medication, and to guide adequate and well-tolerated treatment decisions, it is of paramount importance to expand clinicians’ knowledge of the currently available COX inhibitor/opioid receptor agonist combinations. …”
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    The Expanding Role of the COX Inhibitor/Opioid Receptor Agonist Combination in the Management of Pain
  13. 4593
    “…Hazardous waste management is of paramount importance due to the potential threats posed to the environment and local residents. …”
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    A stochastic network design problem for hazardous waste management
  14. 4594
    “…Therefore, the development of novel and reliable microencapsulated drug formulations granting high efficacy is of paramount importance. Here we report the in vitro delivery of a water-soluble cationic PDT drug, zinc phthalocyanine choline derivative (Cholosens), by biodegradable microcapsules assembled from dextran sulfate (DS) and poly-l-arginine (PArg). …”
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    In Vitro Bioeffects of Polyelectrolyte Multilayer Microcapsules Post-Loaded with Water-Soluble Cationic Photosensitizer
  15. 4595
    “…Because Pakistan is experiencing a large burden of disease, with a sharp rise in confirmed cases, immediate action is of paramount importance to eradicate any potential barriers to a future COVID-19 vaccination program.…”
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    Threat of COVID-19 Vaccine Hesitancy in Pakistan: The Need for Measures to Neutralize Misleading Narratives
  16. 4596
    por Noumonvi, Koffi Dodji, Ferlan, Mitja
    Publicado 2020
    “…However, several phenomena such as the CO(2) degassing and the exchange of cave air return a considerable amount of CO(2) to the atmosphere. It is therefore of paramount importance to understand the contribution of the ecosystem to the carbon budget of karst areas. …”
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    Empirical vs. light-use efficiency modelling for estimating carbon fluxes in a mid-succession ecosystem developed on abandoned karst grassland
  17. 4597
    “…Understanding of the role of focal inflammation, a treatable feature, on neuro-axonal injury, is paramount to optimize neuroprotective strategy in MS. …”
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    Retinal and brain damage during multiple sclerosis course: inflammatory activity is a key factor in the first 5 years
  18. 4598
    “…Careful selection of facial protection is paramount for preventing virus spread among healthcare workers and preserving mask and N95 respirator supplies. …”
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    Masks or N95 Respirators During COVID-19 Pandemic–Which One Should I Wear?
  19. 4599
    “…Introduction  The facial beauty is not easy to define, yet it is paramount to assess the needs of each patient to propose an appropriate treatment plan that will provide beautification or rejuvenation in a natural-looking fashion. …”
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    The Facial Shapes in Planning the Treatment with Injectable Fillers
  20. 4600
    “…To counteract the spread of AR, it is paramount to know which organisms harbor mobile AR genes and which organisms engage in HGT. …”
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    Widespread transfer of mobile antibiotic resistance genes within individual gut microbiomes revealed through bacterial Hi-C
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