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  1. 4601
    “…In the context of epithelial ovarian cancer, a highly heterogeneous disease with diverse subtypes, it is paramount to study a wide panel of models in order to draw a representative picture of the disease. …”
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    Modeling the Diversity of Epithelial Ovarian Cancer through Ten Novel Well Characterized Cell Lines Covering Multiple Subtypes of the Disease
  2. 4602
    “…This is the first study to show that prodigiosin/PU-H71 combination had potent cytotoxicity on MDA-MB-231 cells; proving to play a paramount role in interfering with key signalling pathways in TNBC. …”
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    Prodigiosin/PU-H71 as a novel potential combined therapy for triple negative breast cancer (TNBC): preclinical insights
  3. 4603
    “…Conclusion: In summary, the results showed a greater volume and intensity of workouts accentuate the responses, that are of paramount importance for improving understanding of the effects of CrossFit(®) training and serve as a basis for prescribing future exercise protocols.…”
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    Characterization of Hormonal, Metabolic, and Inflammatory Responses in CrossFit® Training: A Systematic Review
  4. 4604
    “…Deeper understanding of how mammalian cells react to local tissue microenvironment is paramount important when designing next generation of biomaterials for tissue engineering. …”
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    Stepwise 3D-spatio-temporal magnesium cationic niche: Nanocomposite scaffold mediated microenvironment for modulating intramembranous ossification
  5. 4605
    por Watkins, Rachel J., Hsu, Jeremy M.
    Publicado 2020
    “…This is a very complex and challenging clinical situation and timely and appropriate decisions and action are paramount for a positive outcome. Consequently, open pelvic fractures have an extremely high rate of mortality and morbidity and outcomes remain poor, despite evidence-based improvements in treatment, knowledge, and identification of haemorrhage; in the pre-hospital, critical care, and operative settings. …”
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    The Road to Survival for Haemodynamically Unstable Patients With Open Pelvic Fractures
  6. 4606
    “…In this perspective, the identification of people with cognitive frailty (CF), i.e., those individuals with higher risk of developing dementia, on solid pathophysiological bases and with clear operational clinical criteria is of paramount importance. OBJECTIVE/METHODS: This hypothesis paper reviews the current definitions of CF, presents and discusses some of their limitations, and proposes a framework for updating and improving the conceptual and operational definition of the CF construct. …”
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    Towards a Redefinition of Cognitive Frailty
  7. 4607
    “…Humoral immunity to pathogens and other environmental challenges is paramount to maintain normal health, and individuals lacking or unable to make antibodies are at risk. …”
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    Unique repertoire of anti-carbohydrate antibodies in individual human serum
  8. 4608
    “…The correct folding of proteins is of paramount importance for their function, and protein misfolding is believed to be the primary cause of a wide range of diseases. …”
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    Real-time tracking of protein unfolding with time-resolved x-ray solution scattering
  9. 4609
    “…Feature generation is of paramount importance in any pattern recognition task. …”
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    A Semi-supervised Learning Method for Q-Matrix Specification Under the DINA and DINO Model With Independent Structure
  10. 4610
    “…In Bangladesh, with the mounting esteem of bakery products, food safety issues in bakery industries are a paramount concern nowadays. In this regard, this current study was performed to evaluate food safety knowledge, attitude, and self-reported practices of two groups (160 trained and 55 new untrained) of workers from two popular baking industries in Dhaka, Bangladesh. …”
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    Evaluation of food safety knowledge, attitude, and self-reported practices of trained and newly recruited untrained workers of two baking industries in Dhaka, Bangladesh
  11. 4611
    “…For development of preclinical countermeasures, reliable and well-characterized small animal disease models will be of paramount importance. Here we show that intranasal inoculation of SARS-CoV-2 into Syrian hamsters consistently caused moderate broncho-interstitial pneumonia, with high viral lung loads and extensive virus shedding, but animals only displayed transient mild disease. …”
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    Defining the Syrian hamster as a highly susceptible preclinical model for SARS-CoV-2 infection
  12. 4612
    “…Therefore, the assessment of a patient’s biological age and effective organ functional reserve becomes paramount. This may then guide treatment decisions by better estimating a prognosis and the risk-to-benefit ratio of a given therapy to anticipate and mitigate against potential toxicities/difficulties. …”
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    The care of older cancer patients in the United Kingdom
  13. 4613
    “…In the case of bilateral reconstructions, symmetric scar placement is paramount to optimizing aesthetic outcomes. CONCLUSIONS: The mastectomy incision pattern significantly affects the aesthetic outcomes in breast reconstruction. …”
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    Mastectomy Incision Design to Optimize Aesthetic Outcomes in Breast Reconstruction
  14. 4614
    “…The occurrence of the SARS-CoV2 infection has become a worldwide threat and the urgent need to discover therapeutic interventions remains paramount. The primary roles of the coronavirus nucleocapsid (N) protein are to interact with the viral genome and pack them into ribonucleoprotein complex. …”
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    Targeting the SARS-CoV2 nucleocapsid protein for potential therapeutics using immuno-informatics and structure-based drug discovery techniques
  15. 4615
    “…For this reason, timely diagnosis and adequate therapeutic management are paramount. Of potential acute kidney injury (AKI) biomarkers, non-protein-coding RNAs are a subject of ongoing research. …”
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    Acute Kidney Injury in Septic Patients Treated by Selected Nephrotoxic Antibiotic Agents—Pathophysiology and Biomarkers—A Review
  16. 4616
    “…Formation of a ternary complex between the protein target, the PROTAC, and the recruited E3 ligase is considered paramount for successful degradation. A structural model of this ternary complex could in principle inform rational PROTAC design. …”
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    PRosettaC: Rosetta Based Modeling of PROTAC Mediated Ternary Complexes
  17. 4617
    por Zhang, Wen-chao, Xiao, Deng
    Publicado 2020
    “…BACKGROUND: Optimal balance control is of paramount importance for function recovery after total joint arthroplasty (TJA). …”
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    Efficacy of proprioceptive training on the recovery of total joint arthroplasty patients: a meta-analysis
  18. 4618
    por El Taguri, Adel, NASEF, Aisha
    Publicado 2020
    “…This gains particular importance when the disease is rare or lethal which is particularly so in the case of COVID-19. It is of paramount importance to explore some of the available tools that could help accelerate the adoption of any or some of the many proposed modalities for the treatment of diseases. …”
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    The world is waiting, use sequential analysis and get us the evidence-based treatment we need for COVID-19
  19. 4619
    “…Therefore, the establishment of novel approaches that are independent of whole pathogen cultivation, cost-effective, and able to be rapidly developed and produced on a large scale are of paramount importance for global health. This article summarizes the current efforts to develop a COVID-19 vaccine, including the ongoing and future anticipated clinical trials. …”
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    The Race for a COVID-19 Vaccine: Current Trials, Novel Technologies, and Future Directions
  20. 4620
    “…Our results suggest that astrocytes play a critical role in synaptic computation during postnatal development and are of paramount importance in guiding the development of brain circuit functions, learning and memory.…”
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    Astrocyte-mediated spike-timing-dependent long-term depression modulates synaptic properties in the developing cortex
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